AutismKB 2.0

Annotation Detail for PLK4


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Basic Information Top
Gene Symbol:PLK4 ( SAK,STK18 )
Gene Full Name: polo-like kinase 4
Band: 4q28.1
Quick LinksEntrez ID:10733; OMIM: 605031; Uniprot ID:PLK4_HUMAN; ENSEMBL ID: ENSG00000142731; HGNC ID: 11397
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
Pathway IDPathway Name
200153PLK2 and PLK4 events
200176Polo-like kinase signaling events in the cell cycle
No data
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PLK4 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PLK4 mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of PLK4 mRNAincreases expression 16474171
D003345 Corticosterone Corticosterone results in decreased expression of PLK4 mRNAdecreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of PLK4 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PLK4 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PLK4 mRNA]decreases reaction|increases expression 17854601
D004958 Estradiol Estradiol results in increased expression of PLK4 mRNAincreases expression 16474171
D004958 Estradiol Estradiol affects the expression of PLK4 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PLK4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLK4 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PLK4 mRNAaffects expression 17351261
D019833 Genistein Genistein results in increased expression of PLK4 mRNAincreases expression 16474171
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of PLK4 mRNAincreases expression 20713471
D010126 Ozone Ozone results in increased expression of PLK4 mRNAincreases expression 19555225
12763052
C006253 pirinixic acid pirinixic acid results in increased expression of PLK4 mRNAincreases expression 12832660
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of PLK4 mRNAincreases expression 16474171
D011374 Progesterone Progesterone affects the expression of PLK4 mRNAaffects expression 17251523
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLK4 mRNAaffects cotreatment|increases expression 17942748
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of PLK4 mRNAdecreases expression 17951470
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8714514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.1720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 10.1711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.1714692618
MESH:D000230 Adenocarcinoma Genistein 10.1711473722
MESH:D000236 Adenoma Benzo(a)pyrene 11.246695378
MESH:D000236 Adenoma Diethylnitrosamine 11.246695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 11.246695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.4117162532 19061943 18056438 17620307 16434500 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.4116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.4116835633
MESH:D000544 Alzheimer Disease Ozone 2.4415513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5615570426
MESH:D001249 Asthma Ozone 2.6417854713 16373670
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4511922910
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001862 Bone Resorption bisphenol A 3.8711985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 4.2715665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.7420146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 4.7417123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.7417474063
MESH:D001943 Breast Neoplasms Estradiol 4.7418497071 17261762 17289903 16675129 17018787 19861407 14630087 12948864
MESH:D001943 Breast Neoplasms Genistein 4.7417200150 16541309 16873071
MESH:D001943 Breast Neoplasms Methylcholanthrene 4.7417474063
MESH:D001943 Breast Neoplasms Progesterone 4.7417614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.7420435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6816777450 17626835 18417511 14754758 15516495 19059883 18315731
MESH:D002100 Cachexia Ozone 4.7616183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D002277 Carcinoma Methylcholanthrene 8.3410545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.3416835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6318788625 19519916 19919837 11831363 18978308 19822196 20514400 20524982 10672840 19394651 3084413 19418558 16288022 18056438 17173139 18494052 18393292 19383236 16540662 19107877 16328049 21159647 19208518 17162532 16830150 16681979 17138121 20935162 19171122 16807293 19052882 18971187 17055752 20084675 20214788 18665156 16935385 19335982 20727157 10737359 19539802 20512989 18210153 20432363 19701751 20007298 16878318 20101231 16502159 18506893 16698587 17761372 17978847 18785209 16569478 17428255 3581430 18691550 16779866
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6316924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.6316924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0117123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0520419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3716120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Genistein 3.3016332659
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 21.1320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.1312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 21.1317174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 21.1318566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 21.1316192471
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.3319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.3316835633
MESH:D002779 Cholestasis Cyclosporine 13.3619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.3617681005 16919318 15861022 17333356 17110522 11677210 16105132
MESH:D002779 Cholestasis pirinixic acid 13.3619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.108697196 12621046 15668235 15340226 16354765
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7315531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003704 Dementia Polychlorinated Biphenyls 4.7016140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.1120387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.1116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.1117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.7319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004487 Edema pirinixic acid 6.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.0717692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.6116402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.5111473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.5111473722
MESH:D004715 Endometriosis Progesterone 8.9416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.9410568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3520426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Cyclosporine 18.7819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 18.7820387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.7815345470
MESH:D005234 Fatty Liver pirinixic acid 18.7819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9614633661 10962813
MESH:D005355 Fibrosis Cyclosporine 8.5312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5320067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D005909 Glioblastoma Genistein 3.2616598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4510048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.3119772884 19176532 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.3115340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.088697196 18606429 15340226 16354765 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006973 Hypertension Cyclosporine 4.9510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4917937319
MESH:D007249 Inflammation Diethylnitrosamine 8.3118785209
MESH:D007249 Inflammation Progesterone 8.3115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3112200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 12.3316393666
MESH:D007333 Insulin Resistance Estradiol 12.3316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.3316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Cyclosporine 5.9418776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 5.9415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2812371664
MESH:D007680 Kidney Neoplasms Estradiol 7.2815610895
MESH:D007938 Leukemia Genistein 3.0218980019 17468513
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8220032147 19638242 18522880 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.9317823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9312878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1017034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.6720195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.6720583210 19073162 15175105 20492335 18644402 15885732 20137499 9163691 19254457 20405173 12771043 21167192 12112319 20452335 18977376 19812893 20101389 19850985 18648771 19642983 18754104 21278145 19690152 19090486 19255062 19256749 2862719 19833225 19294768 21047994 19426721 2422723 19996281 20501860 19638242 18978307 20118626 19551842 19427195 21071580 16942905 20434301 10737359 19499222
MESH:D008113 Liver Neoplasms pirinixic acid 10.6716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.6716984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.2118775883 18282651 19004024 9362446 19126423 16842330 17854601 19009564 2563599 19519916 18544905 19539802 3124819 16267830 17174075 17942915 18079962 18093689 18164116 21159647 18308698 18253720
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 14.21598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 14.211423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.2112151625
MESH:D008171 Lung Diseases Ozone 3.3819066396 8266340
MESH:D055370 Lung Injury Ozone 3.8620417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.6018569708 18520028 18816296 17053015 20464547 20869020 6695378 20135361 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.6020970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.607750092 6695378 16271038 15390079 9230183 16337739 20970405 20512841 1399818 21163286 11893704 17909032 10545420
MESH:D008175 Lung Neoplasms Ozone 6.607614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6019555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 14.3512807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.3517203775 11408345 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 14.3514578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 14.3517203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.5119453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D008679 Metaplasia Ozone 5.1410496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009203 Myocardial Infarction Genistein 5.6817141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.6819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.1816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.1817141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.1816411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.579029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.8211141357
MESH:D009369 Neoplasms pirinixic acid 4.8217405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 23.5516427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 23.5516427766 11399458
MESH:D009421 Nervous System Malformations Genistein 23.5516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 23.5514600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1520387270
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D010024 Osteoporosis Genistein 3.2519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0916169203
MESH:D010049 Ovarian Diseases bisphenol A 5.0111985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.9319401270
MESH:D010051 Ovarian Neoplasms Genistein 7.9319005980
MESH:D010051 Ovarian Neoplasms Progesterone 7.9317393432 16525653
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4216540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3916702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010538 Peritonitis Ozone 4.1416369182
MESH:D011014 Pneumonia Ozone 4.4118381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.9512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.952563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.5810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5811896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.5720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.5720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8716740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8716740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8715378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 1.8715721890
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011629 Puberty, Precocious bisphenol A 4.8110548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.4810029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.3016503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3320155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3318456281
MESH:D019966 Substance-Related Disorders bisphenol A 4.0016045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.987505956
MESH:D013978 Tibial Fractures Estradiol 4.7219048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1817053015
MESH:D014591 Uterine Diseases bisphenol A 5.0414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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