AutismKB 2.0

Annotation Detail for STAG2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:STAG2 ( DKFZp686P168,DKFZp781H1753,FLJ25871,SA-2,SA2,bA517O1.1 )
Gene Full Name: stromal antigen 2
Band: Xq25
Quick LinksEntrez ID:10735; OMIM: 604359; Uniprot ID:STAG2_HUMAN; ENSEMBL ID: ENSG00000101972; HGNC ID: 11355
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04110Cell cycle
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Pathway IDPathway Name
200087PLK1 signaling events
No data
Pathway IDPathway Name
500976Mitotic Prometaphase
500868Mitotic Metaphase/Anaphase Transition
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of STAG2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of STAG2 mRNAincreases expression 18648102
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of STAG2 mRNAdecreases expression 19150397
20018196
D003010 Clorgyline Clorgyline results in increased expression of STAG2 mRNAincreases expression 19691856
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of STAG2 mRNAaffects expression 17555576
D009151 Mustard Gas Mustard Gas results in increased expression of STAG2 mRNAincreases expression 15674843
D010126 Ozone Ozone results in decreased expression of STAG2 mRNAdecreases expression 17460151
12763052
C410733 scriptaid scriptaid affects the expression of STAG2 mRNAaffects expression 18813790
D012643 Selenium Selenium results in decreased expression of STAG2 mRNAdecreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of STAG2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of STAG2 mRNAaffects expression 18691609
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of STAG2 mRNAincreases expression 19465110
D014810 Vitamin E Vitamin E results in decreased expression of STAG2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.813712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5815570426
MESH:D001249 Asthma Mustard Gas 5.1910378619
MESH:D001249 Asthma Ozone 5.1917854713 16373670
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1911289319 1440618
MESH:D001768 Blister Mustard Gas 5.3119167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9519410462 15565566 16273361 19142967 19189210 20065188 18815881 18997820 20390343 19155303 17242785 18629630 17261762 19084267 17893378 20544844 16873071 18425577 21138602 19244106 19200415 18351453 19221464 18855134 19189212 19103187 21152245 18821012 19115204 16818667 17440819 11161223 19487384 19289846 17049068 19059307 19288272 19011961 20859285 20005174 15668708 19066611 16202921 18984771 20135344
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7618417511 19059883 18315731 15516495 16777450 14754758 17626835
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1517687719 10378619
MESH:D002100 Cachexia Ozone 4.8916183385
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.663581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6616924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.616135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.617505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6120889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.139022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1315861022 16105132 11677210 17681005 16919318 17333356 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1416354765 15668235 8697196 15340226 12621046
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5115322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5119769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.942524372 11298694 8156756 8970840 12868966 18759878 14531868 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.613621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.226482804 1440618 9022650 9328219 9653073 18692083 18289764 6679447 16192314 11289319 18648102 8291058 7440962
MESH:D056486 Drug-Induced Liver Injury Selenium 9.2215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema Mustard Gas 7.219260866 11428647 11402378 11428631
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1119155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004890 Erythema Mustard Gas 5.319357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.473581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4720426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.0615345470
MESH:D005234 Fatty Liver Tamoxifen 8.0619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0920067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7510048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7516080930
MESH:D006333 Heart Failure Selenium 3.1417162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0316120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 8697196 18606429 16354765 16959395
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Mustard Gas 8.6411428620 11428631 8975870 11402378 17524151 11428647 16001271 9357497 9260866
MESH:D007249 Inflammation Tamoxifen 8.6419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6412200463 12878042
MESH:D007251 Influenza, Human Selenium 11.5516624496
MESH:D007251 Influenza, Human Vitamin E 11.5516624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.198074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Vitamin E 2.8612488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.956582329
MESH:D007680 Kidney Neoplasms Tamoxifen 12.9518625569
MESH:D008064 Lipidoses Tamoxifen 3.2315342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.269327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5212878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5216169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.607678174
MESH:D008113 Liver Neoplasms Tamoxifen 7.6016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.162876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.161399818 6587162 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1612151625
MESH:D008171 Lung Diseases Mustard Gas 12.8318702808 18161513
MESH:D008171 Lung Diseases Ozone 12.8319066396 8266340
MESH:D008171 Lung Diseases Vitamin E 12.8316863852
MESH:D055370 Lung Injury Ozone 3.9920417186
MESH:D008175 Lung Neoplasms Mustard Gas 6.723148597 8781369
MESH:D008175 Lung Neoplasms Ozone 6.728597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 6.7218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7211884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 6.7211062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.2715318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.2716827153 11731420 19196723 14580682 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D008679 Metaplasia Ozone 5.2810496685
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0118551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.833581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719200415 19196722 19189210
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D009503 Neutropenia Mustard Gas 4.097688884 16761898
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.234026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010538 Peritonitis Ozone 4.2716369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D011014 Pneumonia Ozone 4.5518929643 18007984 18381685
MESH:D011041 Poisoning Mustard Gas 3.9115727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Clorgyline 2.6919691856
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6915067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6915084515
MESH:D011537 Pruritus Ethinyl Estradiol 10.0515861022 16919318
MESH:D011537 Pruritus Mustard Gas 10.0518058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9617720292 17894541 17620002 17266442 10334151
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6118551238
MESH:D012871 Skin Diseases Mustard Gas 5.1116961503 15451306 12880345
MESH:D012871 Skin Diseases Vitamin E 5.1118709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.976582329 7505956 6587162 1399818 3712494
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.528074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.528653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36177
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved