AutismKB 2.0

Annotation Detail for SIX2


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Basic Information Top
Gene Symbol:SIX2 ( - )
Gene Full Name: SIX homeobox 2
Band: 2p21
Quick LinksEntrez ID:10736; OMIM: 604994; Uniprot ID:SIX2_HUMAN; ENSEMBL ID: ENSG00000170577; HGNC ID: 10888
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SIX2 mRNAdecreases expression 18648102
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of SIX2 mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 3.003712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 6.0911289319 1440618
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.787296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.867296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.087505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.519022650 19486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.5518759878 8156756 8970840 11298694 11906362 14531868 12868966 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.102952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.8116684804
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.069022650 18692083 9328219 6482804 8291058 9653073 1440618 18289764 6679447 11289319 16192314 18648102 7440962
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.193581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 6.096705139
OMIM:136760 FRONTONASAL DYSPLASIA 1 marker/mechanism 18570229
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.647505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.196705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.7015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 6.099022650 8074119
MESH:D007674 Kidney Diseases marker/mechanism 18570229
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.406582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4715034207 9327722
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.80598648 6587162 3712494 1399818
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.623581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.216679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.926482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 6.093988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.247296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.546228378
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.743692021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.261399818 6587162 3712494 6582329 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.428074119
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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