AutismKB 2.0

Annotation Detail for RAI1


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Basic Information Top
Gene Symbol:RAI1 ( DKFZp434A139,KIAA1820,MGC12824,SMCR,SMS )
Gene Full Name: retinoic acid induced 1
Band: 17p11.2
Quick LinksEntrez ID:10743; OMIM: 607642; Uniprot ID:RAI1_HUMAN; ENSEMBL ID: ENSG00000108557; HGNC ID: 9834
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Smith-Magenis syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RAI1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RAI1 mRNAdecreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RAI1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of RAI1 mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RAI1 mRNAdecreases expression 19150397
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.293712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.296695378
MESH:D001008 Anxiety Disorders marker/mechanism 18285828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.7411289319 1440618
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9917474063 20146248
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.1016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.107296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.537505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5320889678
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 20981775
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.449022650 19486331
MESH:D019465 Craniofacial Abnormalities marker/mechanism 19116176
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5818551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.3514531868 11298694 12868966 8970840 2524372 18759878 8156756 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.952952479 3621924
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.1618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.1618648102 16192314 9653073 9022650 18692083 1440618 6482804 6679447 11289319 8291058 18289764 9328219 7440962
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.663581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.6616530937
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006130 Growth Disorders marker/mechanism 18285828
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8320471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.748074119 9022650
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.5216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.526582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4215034207 9327722
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1520195826 21137059
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.751399818 598648 6587162 3712494
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5718816296 6695378 18569708 18520028 20464547 17053015 20869020 20135361 20064080
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4918551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.593581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3311141357
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.156679447
MESH:D019954 Neurobehavioral Manifestations marker/mechanism 19116176
MESH:D009765 Obesity marker/mechanism 15459175 19116176
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.2212819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 10.226482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:C538355 Potocki-Lupski syndrome marker/mechanism 17517686
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D011595 Psychomotor Agitation marker/mechanism 18285828
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5210029692 19755658
MESH:D058496 Smith-Magenis Syndrome marker/mechanism 15459175 15746153 18285828 15788730 19116176 19236431 16845274 17273973 17517686 20981775
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.196587162 6582329 1399818 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 9.0116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 9.018074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 9.0117053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.9510091137
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34188
    • No data
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    PA447216Schizophrenia
    No data
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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