AutismKB 2.0

Annotation Detail for MAP3K2


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Basic Information Top
Gene Symbol:MAP3K2 ( MEKK2,MEKK2B )
Gene Full Name: mitogen-activated protein kinase kinase kinase 2
Band: 2q14.3
Quick LinksEntrez ID:10746; OMIM: 609487; Uniprot ID:M3K2_HUMAN; ENSEMBL ID: ENSG00000169967; HGNC ID: 6854
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04912GnRH signaling pathway
hsa04010MAPK signaling pathway
hsa04540Gap junction
No data
Pathway IDPathway Name
200182Trk receptor signaling mediated by the MAPK pathway
200113ErbB1 downstream signaling
Pathway IDPathway Name
P00018EGF receptor signaling pathway
P00010B cell activation
P00047PDGF signaling pathway
P00021FGF signaling pathway
P00034Integrin signalling pathway
P00036Interleukin signaling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAP3K2 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of MAP3K2 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MAP3K2 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.3018287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.886695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.7319183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9920146248 17474063
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1420419170
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0916530937
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8520471113
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1721137059 20195826
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.6717365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720464547 18520028 18816296 20869020 18569708 20135361 20064080 6695378 17053015
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.3216166281 16966607 18303189
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5316381670
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3511141357
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.5510923243
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9017292933
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1617365031 15814490 17322281 17975199
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5419755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3117053015
Pathway ID Pathway Name
KEGG:04540 Gap junction
KEGG:04912 GnRH signaling pathway
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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