AutismKB 2.0

Annotation Detail for CHL1


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Basic Information Top
Gene Symbol:CHL1 ( CALL,FLJ44930,L1CAM2,MGC132578 )
Gene Full Name: cell adhesion molecule with homology to L1CAM (close homolog of L1)
Band: 3p26.3
Quick LinksEntrez ID:10752; OMIM: 607416; Uniprot ID:CHL1_HUMAN; ENSEMBL ID: ENSG00000134121; HGNC ID: 1939
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Axon guidance
No data
No data
Pathway IDPathway Name
500101CHL1 interactions
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1886Angiomyolipoma
2069Schizophrenia
Desease Name
PSYCH
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CHL1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of CHL1 mRNAaffects expression 17562736
D003024 Clozapine Clozapine results in decreased expression of CHL1 mRNAdecreases expression 14647396
D006220 Haloperidol Haloperidol results in decreased expression of CHL1 mRNAdecreases expression 14647396
D017374 Paroxetine CHL1 affects the susceptibility to Paroxetineaffects response to substance 21332311
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CHL1 mRNAaffects binding|increases activity|increases expression 19710929
C025643 vinclozolin vinclozolin affects the expression of CHL1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000380 Agranulocytosis Clozapine 5.4114617031 12649775 16160616
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8619015723
MESH:D001321 Autistic Disorder Acetaminophen 2.1318445737
MESH:D001321 Autistic Disorder Haloperidol 2.1318080171 19368416
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.927296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.923084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002375 Catalepsy Haloperidol 5.311977408 15215559
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.947505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.529022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.5219176532
MESH:D003072 Cognition Disorders Clozapine 5.3217123785
MESH:D003456 Cryptorchidism vinclozolin 4.6714966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.1520210726
MESH:D003704 Dementia Haloperidol 4.8611575062
MESH:D003866 Depressive Disorder Paroxetine 5.4115014590 17072103
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1514531868 12868966 8970840 8156756 11298694 11906362 18759878 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.793621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.0216402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 6.0015331141
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9411289319 18289764 16192314 8291058 1440618 9653073 9022650 18648102 6482804 18692083 7440962 9328219 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9416109766 10663392 19416960 19739265 17522070 19420014 14725611 2444490 11421492 19923254 16781746 10915739 19085960 11739529 12705907 14550746 12958197 19164858 14986274 11529661 16081117 12153990 17906064 11287661 16177239 18713872 11834606 11743745 16227642 12540782 18071297 12594235 11461765 15619225 16393943 19370779 15968718 17562736 16485898 12392966 10774834
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D050171 Dyslipidemias Clozapine 4.3816402076
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.163581430
MESH:D005234 Fatty Liver pirinixic acid 3.0420131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.7416417039
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006529 Hepatomegaly pirinixic acid 3.3516221962 19772884 18467677 19176532
MESH:D019584 Hot Flashes Paroxetine 6.3714716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006948 Hyperkinesis Clozapine 5.3016046005
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D007248 Infertility, Male vinclozolin 3.2116467254
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.206582329
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1316417039
MESH:D008064 Lipidoses Clozapine 4.1517567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.359327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6819460945 12587719 12969438 16610002 19784758 16611625 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.9016377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.696587162 598648 3712494 1399818
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D001523 Mental Disorders Clozapine 15.9816856516
MESH:D001523 Mental Disorders Haloperidol 15.9816856516
MESH:D001523 Mental Disorders Paroxetine 15.9816856516
MESH:D008607 Mental Retardation marker/mechanism 12812975
MESH:D024821 Metabolic Syndrome X Clozapine 4.6519142101
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity Clozapine 4.8918515891 19142110
MESH:D009765 Obesity pirinixic acid 4.8920558911
MESH:D009771 Obsessive-Compulsive Disorder Paroxetine 6.3417503984
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.686482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2918042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.3318220299
MESH:D011472 Prostatitis vinclozolin 5.3318629315
MESH:D011595 Psychomotor Agitation Haloperidol 5.3111575062
MESH:D011618 Psychotic Disorders Clozapine 9.8115331141
MESH:D011618 Psychotic Disorders Haloperidol 9.8111575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012559 Schizophrenia marker/mechanism 11986985 15653271
MESH:D012559 Schizophrenia Clozapine 4.2117123785 20521326 18806925 11763009 20521320 20580759 19369910 17726453 11151749 17667964 20452607 20168265 18855531 20107430 16141801
MESH:D012559 Schizophrenia Haloperidol 4.2120107430 19369910 18513383 1830565
MESH:D017180 Tachycardia, Ventricular Haloperidol 5.0420210726
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.096587162 6582329 7505956 3712494 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.368074119
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D015430 Weight Gain Clozapine 4.7217502770 16402076 20107430 20521320 16141801 20564506
MESH:D015431 Weight Loss Clozapine 5.4717933447
Pathway ID Pathway Name
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26470
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    PA447216Schizophrenia
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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