AutismKB 2.0

Annotation Detail for GIPC1


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Basic Information Top
Gene Symbol:GIPC1 ( C19orf3,GIPC,GLUT1CBP,Hs.6454,IIP-1,MGC15889,MGC3774,NIP,RGS19IP1,SEMCAP,SYNECTIIN,SYNECTIN,TIP-2 )
Gene Full Name: GIPC PDZ domain containing family, member 1
Band: 19p13.12
Quick LinksEntrez ID:10755; OMIM: 605072; Uniprot ID:GIPC1_HUMAN; ENSEMBL ID: ENSG00000123159; HGNC ID: 1226
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200128Neurotrophic factor-mediated Trk receptor signaling
200115Syndecan-4-mediated signaling events
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
2067Primary tumor
2106Pancreas cancer
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GIPC1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of GIPC1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GIPC1 mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in decreased expression of GIPC1 mRNAdecreases expression 17103032
D001542 Benomyl Benomyl results in increased expression of GIPC1 mRNAincreases expression 15885261
D003633 Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene results in increased expression of GIPC1 mRNAincreases expression 15885261
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GIPC1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GIPC1 mRNAincreases expression 17557909
D005485 Flutamide Flutamide results in increased expression of GIPC1 mRNAincreases expression 15885261
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GIPC1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of GIPC1 mRNAincreases expression 18301758
D011794 Quercetin Quercetin results in increased expression of GIPC1 mRNAincreases expression 15309432
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of GIPC1 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of GIPC1 mRNAincreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of GIPC1 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of GIPC1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 4.9516487989
MESH:D000743 Anemia, Hemolytic Quercetin 4.3517084956
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D000853 Anophthalmos Benomyl 6.1915907663
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001260 Ataxia Telangiectasia Quercetin 5.1315336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Quercetin 4.5519761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 2.8315061365
MESH:D001943 Breast Neoplasms Quercetin 2.8318628248
MESH:D002105 Cadmium Poisoning Quercetin 5.7216962696
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.673084413
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.6712508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0917234771
MESH:D006332 Cardiomegaly Quercetin 3.3719794523
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0116105132 15861022 16919318 17110522 17681005 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 8.0119176532
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D003110 Colonic Neoplasms Quercetin 2.4317148506 11134977 19056647 15741050 16640504 17191121 19440933
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8219496084
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3718713872 16109766 12153990 19739265 10663392 11287661 12594235 16781746 15619225 16227642 12540782 17522070 10774834 14986274 11743745 16485898 2444490 11421492 14550746 12705907 19923254 16081117 11739529 18071297 12392966 16177239 11529661 12958197 19420014 10915739 16393943 17562736 19164858 14725611 19370779 11834606 15968718 11461765 19416960 17906064 19085960
MESH:D056486 Drug-Induced Liver Injury Selenium 6.3715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 5.4416487989
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D005124 Eye Abnormalities Benomyl 5.401914497
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9115345470
MESH:D005234 Fatty Liver pirinixic acid 7.9119236843 20131406
MESH:D005355 Fibrosis Quercetin 4.0419474275
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005909 Glioblastoma Quercetin 3.4619804834
MESH:D005910 Glioma Quercetin 3.0917643826
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0416080930
MESH:D006333 Heart Failure pirinixic acid 7.1720558911
MESH:D006333 Heart Failure Selenium 7.1717162251
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 5.1616487989
MESH:D006529 Hepatomegaly pirinixic acid 3.1316221962 18467677 19176532 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D017588 Hyperandrogenism Flutamide 5.6315356085
MESH:D006943 Hyperglycemia pirinixic acid 9.5920558911
MESH:D006943 Hyperglycemia Quercetin 9.5911834736 18262572
MESH:D006973 Hypertension Quercetin 2.8918356687
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 7.3612948891 17192596
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.3617937319
MESH:D007251 Influenza, Human Quercetin 19.6916624496
MESH:D007251 Influenza, Human Selenium 19.6916624496
MESH:D007251 Influenza, Human Vitamin E 19.6916624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007627 Keloid Quercetin 5.0917086741
MESH:D007674 Kidney Diseases Acetaminophen 10.4612587719 15629191
MESH:D007674 Kidney Diseases Quercetin 10.4616962696
MESH:D007674 Kidney Diseases Vitamin E 10.4612488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.0616705839
MESH:D007938 Leukemia Quercetin 3.2017468513
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 4.7712745335
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6015474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.6012741479
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6519784758 11587558 12969438 16611625 19014921 12587719 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.7216377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 4.7218980244
MESH:D008114 Liver Neoplasms, Experimental Quercetin 3.1219519916
MESH:D008171 Lung Diseases Vitamin E 3.2516863852
MESH:D008175 Lung Neoplasms Quercetin 2.6816280456
MESH:D008175 Lung Neoplasms Vitamin E 2.6811062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8315318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.8619151258
MESH:D009203 Myocardial Infarction Quercetin 5.8619595682
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.7216411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.7219207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009369 Neoplasms pirinixic acid 5.2217405874
MESH:D009369 Neoplasms Quercetin 5.2215185748
MESH:D009421 Nervous System Malformations Benomyl 5.6514502586
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.4817929310
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5316049721 12819281
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.3419495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7619005980
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Quercetin 2.8816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D011085 Polycystic Ovary Syndrome Flutamide 5.1115356085
MESH:D011230 Precancerous Conditions Quercetin 4.0819056647
MESH:D011471 Prostatic Neoplasms Flutamide 2.773169114
MESH:D011471 Prostatic Neoplasms Quercetin 2.7714715546 17292933
MESH:D011471 Prostatic Neoplasms Vitamin E 2.7715084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012554 Schistosomiasis japonica Quercetin 5.7216862918
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6018551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3316049721
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.3316720314
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 5.9116487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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