AutismKB 2.0

Annotation Detail for TRAF3IP2


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Basic Information Top
Gene Symbol:TRAF3IP2 ( ACT1,C6orf2,C6orf4,C6orf5,C6orf6,CIKS,DKFZp586G0522,MGC3581 )
Gene Full Name: TRAF3 interacting protein 2
Band: 6q21
Quick LinksEntrez ID:10758; OMIM: 607043; Uniprot ID:CIKS_HUMAN; ENSEMBL ID: ENSG00000056972; HGNC ID: 1343
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of TRAF3IP2 mRNAincreases expression 15761015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TRAF3IP2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of TRAF3IP2 mRNAdecreases expression 17426115
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of TRAF3IP2 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of TRAF3IP2 mRNAaffects cotreatment|decreases expression 19059307
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.2714745880
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3611798837 19825857
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D000419 Albuminuria Raloxifene 5.1017308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.6015800139
MESH:D015535 Arthritis, Psoriatic marker/mechanism 20953186 20953188
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.4516206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.4519483382
MESH:D001930 Brain Injuries Raloxifene 5.0416580743
MESH:D001943 Breast Neoplasms Raloxifene 2.2816912660 15775269 17595753 17049068 15572757 15758505 16837676 17952589 17893378 17440819 17242785 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 2.2819244106 19115204 19487384 17440819 18984771 20544844 20135344 19221464 20005174 20859285 17261762 19084267 18997820 16873071 11161223 19011961 18351453 19189212 21152245 18815881 19059307 17893378 16202921 15668708 16273361 19189210 20065188 15565566 18855134 16818667 17049068 19288272 19155303 18821012 21138602 19066611 19410462 19142967 18629630 19289846 19200415 20390343 18425577 17242785 19103187
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 5.0719066611
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.2014691202 15073043 16217749 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.2016924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.8417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.8417572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.7115775269
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D003072 Cognition Disorders Raloxifene 5.1815800139
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.9219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.5317474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003928 Diabetic Nephropathies Raloxifene 10.2815920148 17308373 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 10.2819279558
MESH:D004487 Edema pirinixic acid 8.3312083418
MESH:D004487 Edema Raloxifene 8.3315860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.9815845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.9819031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2917893378 16202921 20544844 19155303
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3812903497
MESH:D005234 Fatty Liver arsenic trioxide 22.6015073043
MESH:D005234 Fatty Liver pirinixic acid 22.6019236843 20131406
MESH:D005234 Fatty Liver Raloxifene 22.6017473493
MESH:D005234 Fatty Liver Tamoxifen 22.6014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.1614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.8119069698
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D006331 Heart Diseases Raloxifene 3.8011110106
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly pirinixic acid 3.5519176532 19772884 16221962 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D006973 Hypertension Raloxifene 2.9817577099 15787275
MESH:D007249 Inflammation Tamoxifen 2.5319457130
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3818625569
MESH:D007889 Leiomyoma Raloxifene 4.9616973256
MESH:D007938 Leukemia arsenic trioxide 3.0015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1917050201 19850784 20471514 16968895 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4615213294 19642359 17649720 17869043 15622746 12018890 16891316 11468182 16823087 16330433 19075265 12712474 16112521 17217047 11161223 16331271 19225113 15748426 16966277 17107899 19035177 15336539 9834237 12679006 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D008064 Lipidoses Tamoxifen 3.4317567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.4118564211
MESH:D008113 Liver Neoplasms arsenic trioxide 8.1414682389
MESH:D008113 Liver Neoplasms pirinixic acid 8.1415890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 8.1416684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5719825857 11798837
MESH:D008175 Lung Neoplasms Tamoxifen 2.5718625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3919428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8614580682 16827153 11731420 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 5.2719453300
MESH:D008545 Melanoma Tamoxifen 1.9212393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.8115990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.2815863610
MESH:D009101 Multiple Myeloma arsenic trioxide 8.3415949261 14977855 19417148 11468182 19549372
MESH:D009101 Multiple Myeloma Raloxifene 8.3416497877
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3416105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009232 Myxoma Raloxifene 6.2816343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6119410462
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.7219196722 19200415 19189210
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3610525206
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010024 Osteoporosis Raloxifene 3.6115775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.6917893378 15579764 17823083 15758505
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5019769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6315580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5519131511
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5516220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5515067354
MESH:D011565 Psoriasis marker/mechanism 20953186 20953188 20953190
MESH:D011693 Purpura Raloxifene 6.2815770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
MESH:D013088 Spermatocele Tamoxifen 5.0216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.6719457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Raloxifene 4.1516837676
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3919014326
MESH:D013978 Tibial Fractures Raloxifene 5.9319048282
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5915213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 9.1412845720 11780464 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 9.1417572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 9.148653321 16712894 17572228
MESH:D054556 Venous Thromboembolism Raloxifene 5.9316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.2816343187
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25938
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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