AutismKB 2.0

Annotation Detail for KDM5B


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Basic Information Top
Gene Symbol:KDM5B ( CT31,FLJ10538,FLJ12459,FLJ12491,FLJ16281,FLJ23670,JARID1B,PLU-1,PLU1,PUT1,RBBP2H1A )
Gene Full Name: lysine (K)-specific demethylase 5B
Band: 1q32.1
Quick LinksEntrez ID:10765; OMIM: 605393; Uniprot ID:KDM5B_HUMAN; ENSEMBL ID: ENSG00000117139; HGNC ID: 18039
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1944Breast cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of KDM5B mRNAdecreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of KDM5B mRNAincreases expression 18648102
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of KDM5B mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of KDM5B mRNAincreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KDM5B mRNAdecreases expression 19150397
20018196
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of KDM5B mRNAaffects expression 17555576
D006851 Hydrochloric Acid Hydrochloric Acid results in decreased expression of KDM5B mRNAdecreases expression 15046208
D012402 Rotenone Rotenone results in increased expression of KDM5B mRNAincreases expression 19013527
D013629 Tamoxifen Tamoxifen affects the expression of KDM5B mRNAaffects expression 17555576
D014212 Tretinoin Tretinoin results in decreased expression of KDM5B mRNAdecreases expression 16788091
D014501 Uranium Uranium affects the expression of KDM5B mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of KDM5B mRNAaffects expression 15672453
C025643 vinclozolin vinclozolin affects the expression of KDM5B mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000138 Acidosis Hydrochloric Acid 5.3116144966 20872349 15920416 12771618 11574821 19262391
MESH:D000141 Acidosis, Renal Tubular Hydrochloric Acid 5.8817183249
MESH:D000142 Acidosis, Respiratory Hydrochloric Acid 5.9520597076
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury Hydrochloric Acid 4.8719760209 19094174 11850527 16759491 11953099 19060228 15970105
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2420464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2414692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.753712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.756695378
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000860 Anoxia Hydrochloric Acid 5.4215090967
MESH:D001008 Anxiety Disorders vinclozolin 3.7019015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1511289319 1440618
MESH:D001778 Blood Coagulation Disorders Hydrochloric Acid 9.8615920416
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.8616206674 16197459
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8717474063 20146248
MESH:D001943 Breast Neoplasms Tamoxifen 1.8719103187 19487384 18629630 19200415 16202921 18997820 11161223 18821012 20135344 18984771 18855134 20005174 19189210 20065188 20544844 17049068 19221464 17242785 15668708 19066611 19189212 17261762 18351453 17440819 17893378 19011961 19084267 16818667 15565566 20859285 19142967 19244106 18815881 21152245 19115204 18425577 19155303 16873071 16273361 19410462 19059307 19289846 19288272 21138602 20390343
MESH:D001943 Breast Neoplasms Tretinoin 1.8716443354 16166294 16873071
MESH:D016535 Bronchial Hyperreactivity Hydrochloric Acid 4.6512378975
MESH:D001986 Bronchial Spasm Hydrochloric Acid 5.6015578804
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.657296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.651917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6420419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6416051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D002386 Cataract Tretinoin 3.1417460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.837505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8320889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.069022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0617110522 17333356 11677210 16919318 15861022 17681005 16105132
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tretinoin 2.709407595
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8210589399 9224671 16925845 9664655 17551590 9125849 9211117 8800419 9142499 14991402
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D003556 Cystitis Hydrochloric Acid 5.6019279288 12599022 20719367 12853844
MESH:D018856 Cystitis, Interstitial Hydrochloric Acid 5.9517714534
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9012868966 14531868 8156756 2524372 18759878 11298694 11906362 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.582952479 3621924
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 1.9818692083 6482804 18289764 7440962 6679447 1440618 11289319 9653073 9328219 16192314 8291058 18648102 9022650
MESH:D004489 Edema, Cardiac Tretinoin 4.6018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.2619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.6119155303 17893378 16202921 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6116569247
MESH:D004935 Esophageal Diseases Hydrochloric Acid 5.9119566590
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.303581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3016530937
MESH:D004941 Esophagitis Hydrochloric Acid 6.1112928072
MESH:D004942 Esophagitis, Peptic Hydrochloric Acid 6.1520516732 14621274 11346197
MESH:D005124 Eye Abnormalities Tretinoin 3.649664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9615345470
MESH:D005234 Fatty Liver Tamoxifen 7.9614986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Hydrochloric Acid 9.6218497604
MESH:D005355 Fibrosis Tretinoin 9.6217994277
MESH:D005739 Gas Poisoning Hydrochloric Acid 5.6012378975
MESH:D005764 Gastroesophageal Reflux Hydrochloric Acid 5.4220616304 19957777 20516732 19951613 12212954 20545468
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D005909 Glioblastoma Tretinoin 3.0517312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006356 Heartburn Hydrochloric Acid 5.9119566590
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7920471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.7914991402 9664655
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006930 Hyperalgesia Tretinoin 3.2816870215
MESH:D006940 Hyperemia Hydrochloric Acid 5.7712646421
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006975 Hypertension, Portal Hydrochloric Acid 5.4516984587
MESH:D006976 Hypertension, Pulmonary Hydrochloric Acid 4.5119262391
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007022 Hypotension Hydrochloric Acid 4.8411574821
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8417937319
MESH:D007248 Infertility, Male vinclozolin 6.8416467254
MESH:D007249 Inflammation Hydrochloric Acid 5.6711574821
MESH:D007249 Inflammation Tamoxifen 5.6719457130
MESH:D007410 Intestinal Diseases Hydrochloric Acid 10.4711574821
MESH:D007410 Intestinal Diseases Tretinoin 10.4717994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.159022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 3.9817551590 15992940
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.616582329
MESH:D007680 Kidney Neoplasms Tamoxifen 7.6118625569
MESH:D007818 Laryngeal Diseases Hydrochloric Acid 6.5016498863
MESH:D007826 Laryngismus Hydrochloric Acid 6.5011510729
MESH:D007938 Leukemia Tretinoin 2.8117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0917596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2016331271 17712046 19225113 17107899 16935935 16823087 15748426 17361223 17506722 17649720 19029980 17294898 16766008 19035177 17301526 19075265 12679006 16788101 16140955 9834237 17217047 16891316 17368321 17339181 19642359
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008064 Lipidoses Tamoxifen 3.2117567588 15342952
MESH:D008103 Liver Cirrhosis Hydrochloric Acid 4.1116984587
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.249327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5118564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5118397230 16248980
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.6120195826 21137059
MESH:D008113 Liver Neoplasms Tamoxifen 4.6116684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.586587162 598648 1399818 3712494
MESH:D008171 Lung Diseases Hydrochloric Acid 4.3416784557
MESH:D055370 Lung Injury Asbestos, Crocidolite 9.9317365036
MESH:D055370 Lung Injury Hydrochloric Acid 9.9318497604 18339021 21114838 15044056 19644408 18573544 15090967 16129981 17627322 20597076 21311175 19262391 11395602 15607125
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.3920064080 18816296 20869020 20464547 6695378 18569708 20135361 17053015 18520028
MESH:D008175 Lung Neoplasms Tamoxifen 2.3918625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6714580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Tamoxifen 3.3319393235 12393984
MESH:D008545 Melanoma Tretinoin 3.3316752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2116966607 18303189 16166281
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1217596541
MESH:D009203 Myocardial Infarction Hydrochloric Acid 3.8418534312
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.793581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1211141357
MESH:D009369 Neoplasms Tretinoin 5.1216594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319200415 19189210 19196722
MESH:D009410 Nerve Degeneration Rotenone 3.9415790535 18619942 17356569
MESH:D009421 Nervous System Malformations Tretinoin 3.879125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.406679447
MESH:D009436 Neural Tube Defects Tretinoin 7.409142499
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.636482804 4026338
MESH:D009784 Occupational Diseases Hydrochloric Acid 9.6312378975
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3716936753
MESH:D010146 Pain Tretinoin 2.9716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010300 Parkinson Disease Rotenone 3.0011535288 18619942 19114014 18191903 15451049 16412576 11445065 16140633 19232380
MESH:D020734 Parkinsonian Disorders Rotenone 4.1515795934 15574749 15927086 18197244
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0010923243
MESH:D011015 Pneumonia, Aspiration Hydrochloric Acid 5.4918497604 15970105 15607125 18573544
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0118220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1117292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D001261 Pulmonary Atelectasis Hydrochloric Acid 6.1520597076
MESH:D011654 Pulmonary Edema Hydrochloric Acid 5.3515090967
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0617365031 17322281 17975199 15814490
MESH:D012128 Respiratory Distress Syndrome, Adult Hydrochloric Acid 4.8418339021 17627322 18549715 16784557 16129981
MESH:D012133 Respiratory Paralysis Hydrochloric Acid 6.5011510729
MESH:D012140 Respiratory Tract Diseases Hydrochloric Acid 5.3020516732
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916283617 16116481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8019755658 10029692
MESH:D012878 Skin Neoplasms Tretinoin 5.8016467112
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0116709447
MESH:D013088 Spermatocele Tamoxifen 12.0116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3620155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.3617261132
MESH:D013276 Stomach Ulcer Hydrochloric Acid 4.3116755016 17189318 15309881
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.346582329 1399818 6587162 3712494 7505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.3417045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.458074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.4517053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.4516712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7516129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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