AutismKB 2.0

Annotation Detail for TOB2


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Basic Information Top
Gene Symbol:TOB2 ( TOB4,TOBL,TROB2 )
Gene Full Name: transducer of ERBB2, 2
Band: 22q13.2
Quick LinksEntrez ID:10766; OMIM: 607396; Uniprot ID:TOB2_HUMAN; ENSEMBL ID: ENSG00000183864; HGNC ID: 11980
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TOB2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TOB2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TOB2 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TOB2 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TOB2 mRNAdecreases expression 20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TOB2 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of TOB2 mRNAdecreases expression 20106945
C051890 irinotecan irinotecan metabolite results in increased expression of TOB2 mRNAincreases expression 15956246
C051890 irinotecan irinotecan results in increased expression of TOB2 mRNAincreases expression 15956246
D007657 Ketone Bodies Ketone Bodies results in decreased expression of TOB2 mRNAdecreases expression 16807920
D010634 Phenobarbital Phenobarbital results in decreased expression of TOB2 mRNAdecreases expression 19363144
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of TOB2 mRNAaffects cotreatment|decreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TOB2 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of TOB2 mRNAaffects expression 20159946
D002762 Cholecalciferol Cholecalciferol results in increased expression of TOB2 mRNAincreases expression 17170073
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of TOB2 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of TOB2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.576195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5711752688 14514962 15322242
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0020464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.3617620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.1016142846
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8917474063 20146248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.1815721981 16011737 15700767 16097048 16050911 18705752 3786805 16124888 15673190 16192424 10355542 16227642
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.1816050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.9516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.953084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.9518788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.951701930 17173139 6705139 20007298 20935162
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.356135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.3520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.3512371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.324080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Cyclosporine 2.9519486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1215340226 8697196 15668235 16354765 12621046
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D003110 Colonic Neoplasms irinotecan 2.6017725105 17287894
MESH:D015179 Colorectal Neoplasms irinotecan 2.3615273666 16391804 18509181 17454858 16303861 18259882 17159606
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5015322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.1418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.1418551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.4718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.4721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.4711739529 16081117 19739265 12958197 11461765 12594235 18713872 11287661 12540782 16485898 12153990 18071297 11529661 12705907 19416960 16393943 14550746 16177239 11743745 16109766 10663392 12392966 17522070 11421492 15968718 19420014 17562736 14725611 19085960 16781746 2444490 11834606 17906064 16227642 19164858 19923254 15619225 14986274 19370779 10915739 10774834
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.479327722 16227642 11566570 21278145 7179309 19085960 4309450 7440962 7120509 15027814 3786805 10092053 17522070 16177239 19336974 10915739 6623471 6884620 3732212 15968718 15998439 2869522
MESH:D056486 Drug-Induced Liver Injury Selenium 15.4715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.4720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004421 Dystonia Phenobarbital 4.061851702
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.183659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.9711558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.596401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.327750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.103659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.8916239168 19224547 17595544 15959796 61145 12795759 12631006 16045604
MESH:D005234 Fatty Liver Cyclosporine 7.8919224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 15.1518705752
MESH:D005355 Fibrosis Cyclosporine 15.1512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.1520067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.2620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.2611294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.2616080930
MESH:D006333 Heart Failure Selenium 3.1117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6619900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 8.6816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6812621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.0714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1418606429 15340226 16354765 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8812200463 12878042
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 10.1812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.188314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.1812488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.6316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.6316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.6312371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7317174718 11903743 16221502 17157831 21278145 16943688 17334410 11408273 16239168
MESH:D008103 Liver Cirrhosis Phenobarbital 6.7321047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4916248980 10355542 12546737 17481882 18418968 17721639 12445421 18054572 15673190 14512876 12898905 17869086 18376398 12586293 18412020 16116963 18187930 12649538 17708605 14748882 16192424 15052691 12632514 15931870 18395914 12389079 15730626 18705752 17525996 16015684 17640975 18277467 17631135 18317297 18156304 17944888 18251166 15650968 12632512 18006644 17714472 15370692 17805973 12666154 17557913 17698563 15818738 17823541 15876570 13678700 12958196 18205269 15338365 15362042 18210741 16136751 17766677 16097048 12667390 17900296 17761835 18339082 18420326 14724832 17922224 18429990 18395095 12609069 12445418 15996030 17976157 14620537 15123356 15057751 12741479 15925388 16011737 16033810 18472332 16027843 16638106 20821823 18279442 15893842 14716833 18263696 15959796 14716496 18166357 18481824 18472094 11481614 17565644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4916169303
MESH:D008107 Liver Diseases Acetaminophen 6.5611587558 16611625 19014921 19460945 16610002 19784758 12587719 12969438
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.5616246199 16964402 17285989 15720792 15830285
MESH:D008107 Liver Diseases Phenobarbital 6.5619363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5817185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5816899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.457678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.4521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.4519294768
MESH:D008113 Liver Neoplasms Phenobarbital 14.4519482888 8742319 21047994 19812893 19073162 15975961
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.4516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.386135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.3812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.3817172636 18308698 6150874 2563599 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.3812151625
MESH:D008171 Lung Diseases Vitamin E 3.2116863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3918816296 20464547 20869020 18520028 20064080 17053015 6695378 18569708 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3911884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.3911062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7915318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D052016 Mucositis irinotecan 5.0917159606
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.6318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.6318551238 7678174
MESH:D009362 Neoplasm Metastasis irinotecan 3.1918259882
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1911141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009447 Neuroblastoma irinotecan 3.508761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.818761367
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.0612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.0616049721
MESH:D010018 Osteomalacia Phenobarbital 4.4517016548
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5116965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.1312371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.132563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6717292933
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.6717024972
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6715084515
MESH:D019310 Pseudolymphoma Phenobarbital 4.5912752131
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 10.0318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.0318551238
MESH:D012640 Seizures Phenobarbital 10.033137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.906407741
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5620155912 2093021
MESH:D013274 Stomach Neoplasms irinotecan 2.5615723263
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.091399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.3816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.3817053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.2710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.2710091137
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
KEGG:03018 RNA degradation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36664
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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