AutismKB 2.0

Annotation Detail for HBS1L


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Basic Information Top
Gene Symbol:HBS1L ( DKFZp686L13262,EF-1a,ERFS,HBS1,HSPC276 )
Gene Full Name: HBS1-like (S. cerevisiae)
Band: 6q23.3
Quick LinksEntrez ID:10767; OMIM: 612450; Uniprot ID:HBS1L_HUMAN; ENSEMBL ID: ENSG00000112339; HGNC ID: 4834
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
Beta thalassemia/hemoglobin E disease
hematological parameters
mean corpuscular volume
other erythrocyte phenotypes
hematocrit
mean corpuscular hemoglobin
Desease Name
Hematological and biochemical traits
Mean corpuscular volume
Red blood cell traits
Hematology traits
Hematological parameters
Hematocrit
Mean corpuscular hemoglobin
Beta thalassemia/hemoglobin E disease
Other erythrocyte phenotypes
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HBS1L mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of HBS1L mRNAaffects expression 17562736
D003474 Curcumin Curcumin results in decreased expression of HBS1L mRNAdecreases expression 18421014
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of HBS1L mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of HBS1L mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HBS1L mRNAaffects cotreatment|increases expression 17942748
D011374 Progesterone Progesterone results in increased expression of HBS1L mRNAincreases expression 18070364
D018038 Sodium Selenite Sodium Selenite results in increased expression of HBS1L mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of HBS1L mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HBS1L mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HBS1L mRNAincreases expression 19465110
17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HBS1L mRNAincreases expression 18796159
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.4617887948
MESH:D000544 Alzheimer Disease Curcumin 2.6615590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7816807698
MESH:D050197 Atherosclerosis Curcumin 3.4518704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Curcumin 4.8019761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7117868700
MESH:D001930 Brain Injuries Progesterone 4.5615845082 15665606 15380490
MESH:D002545 Brain Ischemia Curcumin 4.6716770732
MESH:D001932 Brain Neoplasms Curcumin 4.1617596214
MESH:D001943 Breast Neoplasms Curcumin 1.9916243823 18593918 18462866 19250217
MESH:D001943 Breast Neoplasms Progesterone 1.9915562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 1.9916202921 20065188 20544844 16273361 19011961 17049068 19155303 19103187 19189212 19288272 11161223 19066611 15565566 19059307 19084267 16873071 19142967 18984771 19189210 16818667 18351453 19410462 18815881 17261762 17893378 19244106 20135344 17440819 19221464 17242785 19115204 18425577 15668708 19487384 18629630 19289846 18997820 20390343 18821012 20859285 18855134 21152245 19200415 20005174 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D002277 Carcinoma Curcumin 8.9318593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.9316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.693084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6916924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0418414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8218462866
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0515861022 16919318 11677210 17681005 17333356 16105132 17110522
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915668235 8697196 16354765 15340226 12621046
MESH:D003092 Colitis Curcumin 4.4816782535 16804969 18200517
MESH:D003103 Coloboma Curcumin 4.7918809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5319359593 16340194
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 5.2018497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.5718403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5717107852
MESH:D003928 Diabetic Nephropathies Curcumin 9.7818204486
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.7819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.8017187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.4721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4711529661 12958197 15619225 14725611 12540782 10915739 10774834 16781746 19370779 19739265 14550746 11287661 11739529 16081117 19164858 19416960 12705907 16109766 12392966 17906064 17562736 14986274 12153990 19085960 16485898 18071297 19923254 11461765 2444490 16177239 10663392 11834606 18713872 16227642 19420014 12594235 16393943 15968718 11743745 17522070 11421492
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.4715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004381 Duodenal Ulcer Curcumin 4.3317351913
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 17.0312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 17.0317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.0319031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1920544844 17893378 19155303 16202921
MESH:D004715 Endometriosis Progesterone 9.7016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.7010568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Curcumin 14.6219297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.6215345470
MESH:D005234 Fatty Liver Tamoxifen 14.6214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Curcumin 9.8318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8320067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.0018462866
MESH:D005909 Glioblastoma Curcumin 3.6217596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8118829502 18462866
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.3517701891
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 8697196 18606429 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Curcumin 4.2918704882
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Curcumin 12.9418403477 17151092 16956363
MESH:D007249 Inflammation Progesterone 12.9415869954
MESH:D007249 Inflammation Tamoxifen 12.9419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.9412200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2918200517 18596194
MESH:D007333 Insulin Resistance Sodium Selenite 3.4214714311
MESH:D007414 Intestinal Neoplasms Curcumin 4.4510783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0716705839
MESH:D007680 Kidney Neoplasms Tamoxifen 8.0718625569
MESH:D007889 Leiomyoma Curcumin 4.8318555241
MESH:D007938 Leukemia Curcumin 3.3418462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4516106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.0416106398
MESH:D008064 Lipidoses Tamoxifen 3.3217567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.6418705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.6418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6412878042
MESH:D008107 Liver Diseases Acetaminophen 4.2719014921 16611625 19784758 12587719 12969438 16610002 11587558 19460945
MESH:D008107 Liver Diseases Curcumin 4.2716956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.847678174
MESH:D008113 Liver Neoplasms Tamoxifen 7.8416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.202876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2012151625
MESH:D008175 Lung Neoplasms Curcumin 3.5619359593 18462866 16243823
MESH:D008175 Lung Neoplasms Tamoxifen 3.5618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5619555203 11884234
MESH:D008223 Lymphoma Curcumin 3.7518462866
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D016399 Lymphoma, T-Cell Curcumin 5.0016173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.5711408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5714580682 16827153 11731420 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Curcumin 3.5718462866 17885582
MESH:D008545 Melanoma Tamoxifen 3.5712393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008569 Memory Disorders Curcumin 4.4317263510
MESH:D009101 Multiple Myeloma Curcumin 3.6819372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.2617962980
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009361 Neoplasm Invasiveness Curcumin 4.6518495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 12.1312497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 12.1319189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009423 Nervous System Neoplasms Curcumin 6.0118462866
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity Curcumin 2.7919297423
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010024 Osteoporosis Curcumin 3.6118719352
MESH:D010051 Ovarian Neoplasms Curcumin 5.3018462866 19020741
MESH:D010051 Ovarian Neoplasms Progesterone 5.3017393432 16525653
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0019196508 17440100 19401701
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms Curcumin 2.6012497104 18769126 15129424 10851300 18156803 18226269 11398177
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6018760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D011656 Pulmonary Emphysema Curcumin 4.7619168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2810666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9218045962
MESH:D012509 Sarcoma Curcumin 4.3418462866
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D018805 Sepsis Curcumin 4.2818389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Progesterone 12.0216503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 12.0219457130
MESH:D013276 Stomach Ulcer Curcumin 3.7316631530 19188055
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8516049721
MESH:D001749 Urinary Bladder Neoplasms Curcumin 8.8518593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.8516712894 8653321 17572228
MESH:D014565 Urogenital Neoplasms Curcumin 5.6018462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
KEGG:03015 mRNA surveillance pathway
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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