AutismKB 2.0

Annotation Detail for POP4


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Basic Information Top
Gene Symbol:POP4 ( RPP29 )
Gene Full Name: processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
Band: 19q12
Quick LinksEntrez ID:10775; OMIM: 606114; Uniprot ID:RPP29_HUMAN; ENSEMBL ID: ENSG00000105171; HGNC ID: 30081
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of POP4 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of POP4 mRNAaffects expression 21346803
D002945 Cisplatin POP4 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of POP4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of POP4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POP4 mRNAaffects cotreatment|increases expression 17942748
D018038 Sodium Selenite Sodium Selenite results in increased expression of POP4 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of POP4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POP4 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2411752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D058186 Acute Kidney Injury Cisplatin 4.2415814532 12690470 17670903
MESH:D000230 Adenocarcinoma Cisplatin 4.6511798837 17638652
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.6514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.3314601052
MESH:D001943 Breast Neoplasms Cisplatin 1.9018382427 19526202
MESH:D001943 Breast Neoplasms Tamoxifen 1.9016873071 15565566 19066611 18855134 19288272 19155303 18984771 18351453 16273361 19410462 20390343 19221464 19200415 20544844 21152245 17893378 20005174 18815881 20859285 20135344 17242785 19011961 18821012 15668708 19059307 19084267 16818667 21138602 18425577 17440819 19244106 19487384 17261762 19189210 20065188 19115204 19289846 11161223 16202921 19189212 19142967 17049068 18997820 18629630 19103187
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.9016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.9016705839
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.9017982673
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.9016924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1116685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.8818337622 17066447 6189445
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.956135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717110522 16105132 15861022 17681005 11677210 16919318 17333356
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1115894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015668235 8697196 12621046 15340226 16354765
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0316285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.5615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.5620420201
MESH:D004362 Drug Toxicity Cisplatin 8.8612649298 19839026 12231392 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2116202921 19155303 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004938 Esophageal Neoplasms Cisplatin 2.8315464296 17638652 15173087 16481741 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6415345470
MESH:D005234 Fatty Liver Tamoxifen 8.6414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8915102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.5519898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.6515464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 12621046 16120746
MESH:D006689 Hodgkin Disease Cisplatin 3.8416200630 16170182
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4915340226 18606429 8697196 16354765 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tamoxifen 5.3219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3212878042 12200463
MESH:D007333 Insulin Resistance Sodium Selenite 3.4514714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.5815464296
MESH:D007674 Kidney Diseases Cisplatin 3.3818289764 12231392 15190930 12649298 19839026
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.8116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.8116705839
MESH:D007680 Kidney Neoplasms Tamoxifen 13.8118625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.2411231351
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3512878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.907678174
MESH:D008113 Liver Neoplasms Tamoxifen 7.9016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.276135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2712151625
MESH:D008175 Lung Neoplasms Cisplatin 3.596189445 11798837 17225452
MESH:D008175 Lung Neoplasms Tamoxifen 3.5918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5911884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3614737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7911731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Cisplatin 3.6012374674 17023156 18176117 16432458 18332650 17761969 12883367 16809738 11135225 16248763 18505091 15577323 12393984
MESH:D008545 Melanoma Tamoxifen 3.6019393235 12393984
MESH:D018328 Melanoma, Amelanotic Cisplatin 12.8715990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 12.8715990972
MESH:D008654 Mesothelioma Cisplatin 3.3417638057
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.707678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Cisplatin 3.0516773208
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19189210 19200415
MESH:D009395 Nephritis, Interstitial Cisplatin 4.9315464296
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009447 Neuroblastoma Cisplatin 3.578761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.098761367
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D010051 Ovarian Neoplasms Cisplatin 2.946897625 19769630 17225452 15464296
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0719003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.6415464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.7917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911222880 11399792 11118676 11896295
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2318760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2315067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D051437 Renal Insufficiency Cisplatin 4.7715464296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.7614601052
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.7915464296
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms Cisplatin 2.3315958060 18396642 17522103
MESH:D013736 Testicular Neoplasms Cisplatin 4.9317225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.7216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.7216049721
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 12.7212973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.728653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.4716803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014625 Vaginal Neoplasms Cisplatin 4.9715577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8215869587 14671159
MESH:D014839 Vomiting Cisplatin 5.1611897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
KEGG:03008 Ribosome biogenesis in eukaryotes
KEGG:03013 RNA transport
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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