AutismKB 2.0

Annotation Detail for ARPP21


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Basic Information Top
Gene Symbol:ARPP21 ( ARPP-21,FLJ32997,R3HDM3,RCS,TARPP )
Gene Full Name: cAMP-regulated phosphoprotein, 21kDa
Band: 3p22.3
Quick LinksEntrez ID:10777; OMIM: 605488; Uniprot ID:ARP21_HUMAN; ENSEMBL ID: ENSG00000172995; HGNC ID: 16968
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
Cognitive performance
Desease Name
Cognitive performance
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNAaffects cotreatment|increases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ARPP21 mRNAaffects cotreatment|increases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of ARPP21 mRNAaffects cotreatment|increases expression 16931933
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNAaffects cotreatment|increases expression 16931933
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ARPP21 mRNAaffects binding|increases activity|increases expression 19710929
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ARPP21 mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ARPP21 mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of ARPP21 mRNAaffects cotreatment|increases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.319612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D004362 Drug Toxicity Lamivudine 9.6715040536
MESH:D004362 Drug Toxicity Zidovudine 9.6715040536
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D005234 Fatty Liver pirinixic acid 9.2119236843 20131406
MESH:D005234 Fatty Liver Zidovudine 9.2118299183
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006402 Hematologic Diseases Zidovudine 5.1212579204
MESH:D006509 Hepatitis B Lamivudine 5.4717703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.4715309715 15631357 16476009 12044531 15274664
MESH:D006529 Hepatomegaly pirinixic acid 3.4819176532 18467677 19772884 16221962
MESH:D015658 HIV Infections Indinavir 16.8815388451 11363243 11141242
MESH:D015658 HIV Infections Lamivudine 16.8811141242 20032539 17530837 9296927
MESH:D015658 HIV Infections Saquinavir 16.8815388451 11141242
MESH:D015658 HIV Infections Zidovudine 16.8811363243 20032539 11141242 11698656 17358032
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007680 Kidney Neoplasms Zidovudine 4.0912579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.7920370541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9220007298 15890375 16377806
MESH:D008175 Lung Neoplasms Zidovudine 2.4918800350
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.4517358032
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009164 Mycobacterium Infections Indinavir 6.0221442799
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012206 Rhabdomyolysis Lamivudine 6.089296927
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D014625 Vaginal Neoplasms Zidovudine 5.2412579204
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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