AutismKB 2.0

Annotation Detail for NEK6


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Basic Information Top
Gene Symbol:NEK6 ( SID6-1512 )
Gene Full Name: NIMA (never in mitosis gene a)-related kinase 6
Band: 9q33.3
Quick LinksEntrez ID:10783; OMIM: 604884; Uniprot ID:NEK6_HUMAN; ENSEMBL ID: ENSG00000119408; HGNC ID: 7749
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2022Liver cancer
Desease Name
NEUROLOGICAL
Cognitive performance
Desease Name
Cognitive test performance
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NEK6 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of NEK6 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NEK6 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NEK6 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NEK6 mRNAdecreases expression 19150397
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of NEK6 mRNAincreases expression 16934159
D016572 Cyclosporine Cyclosporine results in decreased expression of NEK6 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of NEK6 mRNAincreases expression 19638242
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NEK6 mRNAincreases expression 17942748
17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEK6 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in decreased expression of NEK6 mRNAdecreases expression 17039268
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NEK6 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of NEK6 mRNAdecreases expression 17426115
C017947 sodium arsenite sodium arsenite results in increased expression of NEK6 mRNAincreases expression 12016162
D013629 Tamoxifen Tamoxifen affects the expression of NEK6 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEK6 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NEK6 mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6414745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.767525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.7611752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1220464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1214692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.1217638652
MESH:D000236 Adenoma Benzo(a)pyrene 6.736695378
MESH:D000236 Adenoma Diethylnitrosamine 6.736695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.7819061943 17620307 16434500 19052882 18056438 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.7816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0017306315 16712894
MESH:D000740 Anemia Fluorouracil 8.8515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.8511748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3420146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3417474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.3419217205 18357371 15136595 16595493 18608205 16110121 16557594
MESH:D001943 Breast Neoplasms Tamoxifen 2.3420065188 18815881 19410462 19084267 19059307 19189212 16273361 17440819 18984771 15565566 17261762 18629630 16202921 18855134 21138602 19155303 20005174 20135344 17242785 15668708 17049068 19011961 18425577 21152245 16873071 17893378 19487384 19115204 19142967 20859285 19289846 19200415 19103187 20544844 19288272 19189210 19066611 11161223 19244106 18351453 16818667 19221464 18821012 18997820 20390343
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3420435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7616051944
MESH:D002277 Carcinoma Fluorouracil 8.3317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.3316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5819066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.5116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.513084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.5119822196 18788625 16698587 18785209 21159647 20084675 18978308 18393292 16540662 16502159 19383236 19052882 18494052 18210153 16935385 3581430 16830150 18506893 16681979 16328049 18056438 19919837 10737359 19701751 18665156 17761372 17055752 3084413 17162532 16807293 16569478 20514400 20432363 16878318 18971187 19519916 19418558 16288022 18691550 17173139 17428255 19171122 19208518 17138121 20935162 20727157 20101231 19335982 11831363 19539802 16779866 17978847 20214788 19394651 20007298 20512989 10672840 20524982 19107877
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.5117971768 16332177 17088986 17045692 16799960 18930000
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.5115276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.5116924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0418695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.6320419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.6316280240 17066447 18986760 16757204
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.6318572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 18670907 16120746
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.5214694615
MESH:D002386 Cataract Acetaminophen 7.5210977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.3320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.3312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.337505956 21159647 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 16.3319524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4916835633
MESH:D002779 Cholestasis Cyclosporine 13.5819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.5811677210 16919318 17333356 16105132 15861022 17681005 17110522
MESH:D002779 Cholestasis pirinixic acid 13.5819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1215340226 8697196 16354765 15668235 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2417018589 18772588 15001691 17172411 17016597 17725105 17169374 16510598 16340194 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0014970324 16331619 16524972 16303861 15289873 15148649 17594712 16282729 18448328 18802399 16391804 18383874 17695437 17454858 17255274 18288408 17094418 20501625 17016601 17401013 18509181 18949393
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.3515095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.3514669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0918551238
MESH:D007644 Darier Disease Fluorouracil 4.8716733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4319031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.4818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.4821346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.4816081117 19416960 14550746 17522070 15619225 17906064 16393943 10915739 19923254 10663392 2444490 19085960 11743745 19739265 10774834 15968718 12540782 16227642 11739529 16781746 19420014 12153990 17562736 11287661 16485898 18071297 12392966 11461765 11529661 14725611 19370779 12958197 12594235 12705907 16109766 11421492 19164858 16177239 14986274 11834606 18713872
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 15.4817851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.4819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.4820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.1612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.1619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0820544844 16202921 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.3116481741 15173087 16785472 16337965 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Cyclosporine 25.2619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 25.2621071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.2615345470
MESH:D005234 Fatty Liver pirinixic acid 25.2620131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 25.2619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2619069698
MESH:D005355 Fibrosis Cyclosporine 8.7212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7220067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005910 Glioma Fluorouracil 2.8916145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4215102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly pirinixic acid 8.5019176532 19772884 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5012621046 16120746 15340226
MESH:D006689 Hodgkin Disease sodium arsenite 3.2012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416959395 8697196 16354765 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.7617937319
MESH:D007248 Infertility, Male sodium arsenite 6.7612646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 8.4318785209
MESH:D007249 Inflammation Tamoxifen 8.4319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.4312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 10.1812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.188314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 10.1820008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.1516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.1512371664
MESH:D007680 Kidney Neoplasms Fluorouracil 18.1516985049
MESH:D007680 Kidney Neoplasms Tamoxifen 18.1518625569
MESH:D008064 Lipidoses Tamoxifen 3.1915342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8518522880 19638242 18665156 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4212878042
MESH:D008107 Liver Diseases Acetaminophen 3.9516610002 16611625 19460945 12587719 12969438 11587558 19784758 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 22.2320195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 22.2312112319 18648771 20405173 9163691 21278145 19090486 18754104 19427195 19426721 19254457 20492335 15885732 19499222 21071580 20452335 16942905 18644402 20501860 19812893 20118626 19294768 18978307 21047994 19255062 19638242 20101389 20137499 2862719 12771043 18977376 10737359 19642983 19690152 19833225 19850985 15175105 20434301 19551842 20583210 19073162 19256749 2422723 19996281 21167192
MESH:D008113 Liver Neoplasms Fluorouracil 22.2317045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 22.2316377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 22.2315276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 22.2316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 22.2316984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.8718079962 18308698 19009564 19519916 18544905 2563599 3124819 18282651 16267830 19004024 18775883 18164116 19539802 18093689 17942915 17854601 19126423 17174075 21159647 18253720 16842330 9362446
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8712151625
MESH:D008171 Lung Diseases sodium arsenite 3.2119095001
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.6418569708 17053015 20869020 18520028 6695378 20135361 20464547 18816296 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.646695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Fluorouracil 8.6415246190
MESH:D008175 Lung Neoplasms sodium arsenite 8.6417306315 17077188 16712894 19931552 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 8.6418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.6419555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8715086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6611731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.6419453300
MESH:D008545 Melanoma sodium arsenite 3.3419082730 16487513
MESH:D008545 Melanoma Tamoxifen 3.3419393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.6716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.6716757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9418551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.803581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5319410462
MESH:D009369 Neoplasms Benzo(a)pyrene 12.0711141357
MESH:D009369 Neoplasms Fluorouracil 12.0718600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 12.0717405874
MESH:D009369 Neoplasms sodium arsenite 12.0711559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7420056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1019200415 19189210 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3318481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1812854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.3318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.3320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4716436463
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3016049721 12819281
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.3014694615
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4517306315 15276417
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3816540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.3816929163 16500647 19003803 15113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.1012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.102563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711896295 11399792 11222880 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0618626508 19082440
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0616039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0615067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0618722050 15538739 16160472 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5718551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.5419755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 9.5418572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.5416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.8916709447
MESH:D013088 Spermatocele Tamoxifen 11.8916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1219457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8412854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.382093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3818456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3816951190 18396642 19084572 17522103 18567086 16424979 19015929 17172411 15786421 17498489
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.027505956
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0416280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.0916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.0917053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.0911723127 16452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.098653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4010091137
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.6616803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.6611813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D014652 Vascular Diseases sodium arsenite 4.5117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5915869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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