AutismKB 2.0

Annotation Detail for WDR4


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Basic Information Top
Gene Symbol:WDR4 ( TRM82 )
Gene Full Name: WD repeat domain 4
Band: 21q22.3
Quick LinksEntrez ID:10785; OMIM: 605924; Uniprot ID:WDR4_HUMAN; ENSEMBL ID: ENSG00000160193; HGNC ID: 12756
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of WDR4 mRNAdecreases expression 18648102
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in decreased expression of WDR4 mRNAdecreases expression 14583596
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of WDR4 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WDR4 mRNAdecreases expression 19150397
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of WDR4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WDR4 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in decreased expression of WDR4 mRNAdecreases expression 16510598
D019833 Genistein Genistein results in decreased expression of WDR4 mRNAdecreases expression 18847459
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WDR4 mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E Vitamin E results in increased expression of WDR4 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.5620464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.5614692618
MESH:D000230 Adenocarcinoma Fluorouracil 10.5617638652
MESH:D000230 Adenocarcinoma Genistein 10.5611473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.963712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.966695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Fluorouracil 9.3317963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.3311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9717474063 20146248
MESH:D001943 Breast Neoplasms Fluorouracil 1.9718357371 16595493 16110121 16557594 19217205 15136595 18608205
MESH:D001943 Breast Neoplasms Genistein 1.9716541309 16873071 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 8.7417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.813581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.8117971768 17045692 17088986 16799960 16332177 18930000
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.8116924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.787296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.7818695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8120419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8118986760 16280240 16757204 17066447
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.4416332659
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.107505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1020889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.3619486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3611677210 17333356 17681005 15861022 16105132 17110522 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815668235 8697196 15340226 12621046 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9618772588 17169374 16510598 17016597 17018589 17287894 17725105 17172411 16340194 15001691
MESH:D003110 Colonic Neoplasms Genistein 3.9617182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018448328 18383874 16391804 17454858 20501625 16331619 15289873 18949393 16524972 18288408 14970324 17255274 17695437 18509181 16282729 17401013 17594712 17094418 18802399 16303861 17016601 15148649
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5315322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5319769572
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0618759878 11906362 12868966 2524372 8970840 14531868 11298694 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.4716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4717107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.8618692083 9653073 18648102 18289764 8291058 6679447 7440962 11289319 16192314 1440618 9022650 9328219 6482804
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.8716402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4911473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 10.773581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.7720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.7716530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.7717638652 16337965 15173087 16785472 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0215345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005909 Glioblastoma Genistein 3.3816598420
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5218337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.6820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.6811294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.6816080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1515340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616354765 15340226 16959395 18606429 8697196
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.5316624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Vitamin E 2.9112488133
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.066582329
MESH:D007680 Kidney Neoplasms Fluorouracil 8.0616985049
MESH:D007938 Leukemia Genistein 3.1118980019 17468513
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.6117823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6116169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8020195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 7.8017045692 16603448 15113037 18383874
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8016984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.133712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1312151625
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0018520028 20064080 17053015 20869020 20135361 20464547 6695378 18569708 18816296
MESH:D008175 Lung Neoplasms Fluorouracil 5.0015246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0019555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 5.0011062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0614578162 12929590
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.0616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.0616757204 18986760
MESH:D009203 Myocardial Infarction Genistein 2.9317141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8217141266
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms 4-phenylbutyric acid 9.0019116145
MESH:D009369 Neoplasms Benzo(a)pyrene 9.0011141357
MESH:D009369 Neoplasms Fluorouracil 9.0016928823 18600527 18239605
MESH:D009421 Nervous System Malformations Genistein 10.4116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.614026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010024 Osteoporosis Genistein 3.3719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3116169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6519005980
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7216929163 16500647 15113037 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0619082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 2.0616925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0615084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1918286688 18722050 16160472 15538739
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.462093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4617522103 18396642 17498489 18567086 19084572 15786421 17172411 19015929 16424979 16951190
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.041399818 6587162 7505956 6582329 3712494
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.208074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2017053015
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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