AutismKB 2.0

Annotation Detail for SLC17A3


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Basic Information Top
Gene Symbol:SLC17A3 ( NPT4 )
Gene Full Name: solute carrier family 17 (sodium phosphate), member 3
Band: 6p22.2
Quick LinksEntrez ID:10786; OMIM: 611034; Uniprot ID:NPT4_HUMAN; ENSEMBL ID: ENSG00000124564; HGNC ID: 10931
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
PSYCH
schizophrenia
METABOLIC
mean corpuscular hemoglobin
serum urate
Desease Name
Serum urate
Mean corpuscular hemoglobin
Desease Name
Glycogen storage disease Ic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SLC17A3 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of SLC17A3 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC17A3 mRNAaffects expression 16483693
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC17A3 mRNAaffects cotreatment|affects expression 17602206
C030123 coumarin coumarin results in increased expression of SLC17A3 mRNAincreases expression 18480146
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC17A3 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC17A3 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of SLC17A3 mRNAincreases expression 19638242
C030957 methylmercury II methylmercury II results in increased expression of SLC17A3 mRNAincreases expression 17905399
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC17A3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of SLC17A3 mRNAdecreases expression 18445702
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.043712494
MESH:D000236 Adenoma Diethylnitrosamine 7.046695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.0617162532 16434500 18056438 19052882 19061943 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0616434500
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.677296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.673084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6711831363 16830150 20101231 19539802 16779866 18971187 18506893 20514400 17761372 17978847 20935162 19052882 17162532 18210153 16807293 17055752 21159647 19208518 18056438 19171122 19107877 16328049 19394651 17138121 19335982 18665156 19822196 20512989 19519916 10672840 20524982 18978308 19383236 19701751 3581430 17173139 20084675 16288022 20432363 16878318 16681979 10737359 18691550 18788625 18785209 16502159 17428255 19919837 20007298 19418558 18494052 16540662 16698587 18393292 16935385 20214788 3084413 20727157 16569478
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.967505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.9612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.9617174075 7505956 2727394 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.2719486331 9022650
MESH:D002779 Cholestasis Cyclosporine 14.2719486331
MESH:D002779 Cholestasis pirinixic acid 14.2719176532
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0614531868 8156756 2524372 12868966 11298694 8970840 11906362 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 4.9319647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.9320387270
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.499653073 9328219 8291058 18692083 11289319 7440962 9022650 18289764 6482804 6679447 1440618 18648102 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4916485898 16081117 11287661 14986274 11461765 17522070 12594235 16177239 17906064 16109766 11739529 12392966 19420014 15968718 19923254 16227642 19370779 19085960 14550746 12958197 16393943 11421492 11529661 16781746 2444490 15619225 19416960 11834606 17562736 14725611 10663392 10774834 18071297 12705907 19739265 18713872 11743745 12153990 10915739 12540782 19164858
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4919107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Cyclosporine 14.2819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 14.2820387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 14.2820131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Cyclosporine 3.4012639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly pirinixic acid 3.2519176532 18467677 19772884 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007249 Inflammation Diethylnitrosamine 2.4718785209
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.168314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.856582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9320032147 18522880 18407596 19638242 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.0511587558 12969438 19014921 19460945 19784758 16610002 12587719 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Clofibric Acid 7.8717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.8718648771 2422723 20434301 19833225 18754104 9163691 19090486 20405173 15175105 18978307 2862719 20452335 19690152 20501860 21167192 10737359 19642983 20492335 19996281 19812893 19294768 15885732 21071580 20118626 20137499 19073162 19551842 19499222 18644402 16942905 20583210 19427195 20101389 21047994 19850985 19256749 19426721 21278145 18977376 19638242 19255062 12771043 19254457 12112319
MESH:D008113 Liver Neoplasms pirinixic acid 7.8715890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.321399818 6587162 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.329362446 18775883 19519916 19126423 18308698 18079962 18282651 17174075 19539802 18544905 16267830 18093689 17854601 21159647 2563599 19004024 19009564 18164116 16842330 17942915 3124819 18253720
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7621163286 20970405 20512841 6695378
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.943581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.943581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.614026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011230 Precancerous Conditions Cyclosporine 9.5612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.562563599
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.643712494 6582329 6587162 1399818 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.647505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.348074119
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014689 Venous Insufficiency coumarin 6.0912708602
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35822
    • Releated gene ID Related gene Name
    PA35822SLC17A3
    No data
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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