AutismKB 2.0

Annotation Detail for NCKAP1


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Basic Information Top
Gene Symbol:NCKAP1 ( FLJ11291,HEM2,KIAA0587,MGC8981,NAP1,NAP125 )
Gene Full Name: NCK-associated protein 1
Band: 2q32.1
Quick LinksEntrez ID:10787; OMIM: 604891; Uniprot ID:NCKP1_HUMAN; ENSEMBL ID: ENSG00000061676; HGNC ID: 7666
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
No data
Pathway IDPathway Name
200155Stabilization and expansion of the E-cadherin adherens junction
200113ErbB1 downstream signaling
200105E-cadherin signaling in the nascent adherens junction
200190RAC1 signaling pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NCKAP1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of NCKAP1 mRNAincreases expression 20458559
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NCKAP1 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of NCKAP1 mRNAincreases expression 20106945
D016190 Carboplatin Carboplatin results in decreased expression of NCKAP1 mRNAdecreases expression 18172885
D002945 Cisplatin Cisplatin results in decreased expression of NCKAP1 mRNAdecreases expression 18172885
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NCKAP1 mRNAaffects cotreatment|affects expression 17602206
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of NCKAP1 geneincreases mutagenesis 15755804
D008466 Mechlorethamine Mechlorethamine results in decreased expression of NCKAP1 mRNAdecreases expression 17107856
D009151 Mustard Gas Mustard Gas results in increased expression of NCKAP1 mRNAincreases expression 12884408
D002762 Cholecalciferol Cholecalciferol results in increased expression of NCKAP1 mRNAincreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D058186 Acute Kidney Injury Cisplatin 4.1012690470 17670903 15814532
MESH:D000230 Adenocarcinoma arsenic trioxide 4.7419825857 11798837
MESH:D000230 Adenocarcinoma Cisplatin 4.7417638652 11798837
MESH:D000236 Adenoma Diethylnitrosamine 7.286695378 10737359
MESH:D000236 Adenoma Ethylnitrosourea 7.286695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0918056438 19061943 17162532 17620307 19052882 16434500
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.2016142846
MESH:D001768 Blister Mustard Gas 5.3519167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8116206674
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.1014601052
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0114991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4215144691 16357521 16651633 18412241 16436596
MESH:D001943 Breast Neoplasms Cisplatin 2.3619526202 18382427
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3617474063
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1917687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002057 Burns, Chemical Mechlorethamine 6.459625245
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8014691202 15553829 16217749 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.8017982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.8018506893 3581430 3084413 20935162 17761372 18665156 19208518 20432363 17138121 20512989 19919837 10737359 16328049 18494052 19171122 20084675 20524982 18788625 16502159 17428255 18393292 19107877 16288022 19335982 19701751 11831363 16935385 18691550 17173139 19383236 19539802 16681979 20007298 19394651 20214788 16830150 19052882 18785209 18210153 18978308 17978847 19519916 16569478 16878318 10672840 17162532 17055752 16698587 20101231 18056438 16540662 19418558 20727157 16807293 20514400 16779866 21159647 19822196 18971187
MESH:D002289 Carcinoma, Non-Small-Cell Lung Carboplatin 6.3016685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 6.3012023789 16685392
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.8518337622 17066447 6189445
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.8412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.8417174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 11.8416003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.2017160924
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7020501625
MESH:D015179 Colorectal Neoplasms Cisplatin 2.7015273666
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.0919107877
MESH:D004362 Drug Toxicity Cisplatin 3.9615033597 19839026 12231392 12649298
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.2018357618
MESH:D004487 Edema Mustard Gas 3.4511428631 9260866 11402378 11428647
MESH:D004890 Erythema Mustard Gas 5.359357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.8312903497
MESH:D004938 Esophageal Neoplasms Cisplatin 4.8317638652 16481741 15173087 16785472 15464296
MESH:D005234 Fatty Liver arsenic trioxide 13.9515073043
MESH:D005234 Fatty Liver Cyclosporine 13.9519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 13.9521071580 20387270
MESH:D005355 Fibrosis Cyclosporine 3.3212639820 12168785
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005909 Glioblastoma Ethylnitrosourea 3.9216436596
MESH:D005910 Glioma Ethylnitrosourea 3.5416357521 18412241 16651633
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8015102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.4219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5415464296
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006689 Hodgkin Disease Cisplatin 3.7216200630 16170182
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D007249 Inflammation Diethylnitrosamine 5.4618785209
MESH:D007249 Inflammation Mustard Gas 5.4611428620 9357497 17524151 8975870 11428631 11428647 9260866 16001271 11402378
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.3615464296
MESH:D007674 Kidney Diseases Cisplatin 6.4315190930 12649298 18289764 12231392 19839026
MESH:D007674 Kidney Diseases Cyclosporine 6.4318776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0212371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 8.0217379185
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.0111231351
MESH:D007938 Leukemia arsenic trioxide 2.8915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1620471514 16968895 17050201 19850784 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3017649720 12018890 16823087 15622746 17869043 16330433 12679006 15336539 12712474 17217047 19035177 16331271 17712046 15748426 16891316 11161223 19225113 11468182 15213294 16112521 17107899 16966277 9834237 19075265 19642359
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8920032147 18665156 18522880 19638242 18407596
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms arsenic trioxide 7.8214682389
MESH:D008113 Liver Neoplasms Clofibric Acid 7.8217602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.8215175105 19996281 19690152 21167192 12771043 21071580 19812893 19073162 19254457 21047994 20137499 19642983 21278145 19551842 12112319 20405173 19499222 9163691 16942905 20501860 20452335 19255062 18977376 19427195 19426721 19090486 18648771 19256749 20101389 19833225 18754104 20583210 19638242 20118626 18644402 15885732 10737359 2422723 2862719 19294768 18978307 19850985 20434301 20492335
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.2720377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.2718544905 19539802 18164116 16842330 18775883 18093689 18079962 17174075 19126423 19004024 16267830 21159647 2563599 17942915 3124819 18308698 18282651 17854601 18253720 19009564 19519916 9362446
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D008171 Lung Diseases Mustard Gas 3.5418161513 18702808
MESH:D008175 Lung Neoplasms arsenic trioxide 6.7819825857 11798837
MESH:D008175 Lung Neoplasms Cisplatin 6.7817225452 6189445 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.7820512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Ethylnitrosourea 6.7817703301 16019985 6695378 16271038
MESH:D008175 Lung Neoplasms Mustard Gas 6.783148597 8781369
MESH:D008223 Lymphoma Ethylnitrosourea 4.0415790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.2215375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.5918041768 10767621 10838139
MESH:D008545 Melanoma Carboplatin 4.1116225601 11712820 12040289 16342250
MESH:D008545 Melanoma Cisplatin 4.1116809738 11135225 15577323 18176117 12393984 12374674 17023156 16248763 17761969 18332650 16432458 12883367 18505091
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.9715990972
MESH:D008579 Meningioma Ethylnitrosourea 6.2017943659
MESH:D008654 Mesothelioma Cisplatin 3.2917638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2014977855 19417148 19549372 15949261 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2216105982 16882451
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.613581430 9029167
MESH:D009369 Neoplasms Carboplatin 6.0318854779 17925555
MESH:D009369 Neoplasms Cisplatin 6.0316773208
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.5816707424
MESH:D009395 Nephritis, Interstitial Cisplatin 4.7115464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2010525206
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.6116651423 17160924 16003739
MESH:D009447 Neuroblastoma Cisplatin 3.518761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D017599 Neuroectodermal Tumors Carboplatin 12.4612837982
MESH:D017599 Neuroectodermal Tumors Cisplatin 12.468761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009503 Neutropenia Mustard Gas 4.1216761898 7688884
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.2017160924
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2016624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Cisplatin 5.2019769630 15464296 17225452 6897625
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.9515580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.9519003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.9516540662
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4715464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.5617638057
MESH:D011041 Poisoning Mustard Gas 3.9415727166
MESH:D011230 Precancerous Conditions Cyclosporine 9.3612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.362563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.6019131511
MESH:D011471 Prostatic Neoplasms Cholecalciferol 3.6017024972
MESH:D011537 Pruritus Mustard Gas 4.2918058305
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9717266442 17720292 17894541 10334151 17620002
MESH:D051437 Renal Insufficiency Cisplatin 4.5815464296
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.8916646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 10.8914601052
MESH:D012871 Skin Diseases Mustard Gas 2.7416961503 12880345 15451306
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.5615464296
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5017007042
MESH:D013274 Stomach Neoplasms Cisplatin 3.5015958060 18396642 17522103
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.5018456281
MESH:D015173 Supratentorial Neoplasms Carboplatin 6.0012837982
MESH:D013736 Testicular Neoplasms Cisplatin 4.7815464296 17225452
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.3515790496
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5519014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.557505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.4912845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.4912973940 17225452 15464296
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.3416803524
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.7815577323
MESH:D014839 Vomiting Cisplatin 4.9311897121
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:04810 Regulation of actin cytoskeleton
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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