AutismKB 2.0

Annotation Detail for IQGAP2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:IQGAP2 ( - )
Gene Full Name: IQ motif containing GTPase activating protein 2
Band: 5q13.3
Quick LinksEntrez ID:10788; OMIM: 605401; Uniprot ID:IQGA2_HUMAN; ENSEMBL ID: ENSG00000145703; HGNC ID: 6111
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1841Stomach cancer
Desease Name
CHEMDEPENDENCY
hearing impairment
smoking cessation
Desease Name
Hearing impairment
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of IQGAP2 proteinaffects expression 20106945
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of IQGAP2 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of IQGAP2 mRNAdecreases expression 20064835
20106945
D003035 Cobalt [tungsten carbide binds to Cobalt] which results in decreased expression of IQGAP2 mRNAaffects binding|decreases expression 20105288
C018021 cobaltous chloride cobaltous chloride results in decreased expression of IQGAP2 mRNAdecreases expression 20105288
D016572 Cyclosporine Cyclosporine results in decreased expression of IQGAP2 mRNAdecreases expression 20106945
D004610 Ellagic Acid Ellagic Acid results in increased expression of IQGAP2 mRNAincreases expression 12002526
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of IQGAP2 mRNA]affects reaction|decreases expression 15016801
D019833 Genistein Genistein results in decreased expression of IQGAP2 mRNAdecreases expression 15378649
D007529 Isoflavones Isoflavones results in decreased expression of IQGAP2 mRNAdecreases expression 17374662
D018038 Sodium Selenite Sodium Selenite results in increased expression of IQGAP2 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IQGAP2 mRNAincreases expression 19465110
C002802 tungsten carbide [tungsten carbide binds to Cobalt] which results in decreased expression of IQGAP2 mRNAaffects binding|decreases expression 20105288
C002802 tungsten carbide tungsten carbide results in decreased expression of IQGAP2 mRNAdecreases expression 20105288
D014501 Uranium Uranium affects the expression of IQGAP2 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of IQGAP2 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9015322242 11752688 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1820127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 7.1817638652
MESH:D000230 Adenocarcinoma Genistein 7.1811473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.676695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D000505 Alopecia Isoflavones 4.7417569567
MESH:D000740 Anemia Fluorouracil 8.7715504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.7711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3620146248 17474063
MESH:D001943 Breast Neoplasms Cobalt 2.3615986119
MESH:D001943 Breast Neoplasms Fluorouracil 2.3616595493 19217205 18608205 15136595 18357371 16110121 16557594
MESH:D001943 Breast Neoplasms Genistein 2.3616873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3620435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7316051944
MESH:D002277 Carcinoma Fluorouracil 8.2617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.2616835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7112907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7117045692 17971768 16332177 17088986 18930000 16799960
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7116924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6720419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.6716757204 16280240 18986760 17066447
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 7.8316332659
MESH:D002318 Cardiovascular Diseases Isoflavones 7.8317689850
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Cyclosporine 2.9419486331
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7915894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1115668235 8697196 12621046 15340226 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8717725105 17016597 15001691 17172411 16510598 18772588 17018589 17287894 16340194 17169374
MESH:D003110 Colonic Neoplasms Genistein 3.8717182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.9318509181 17094418 18802399 14970324 20501625 17594712 17454858 17255274 17695437 16391804 17401013 15289873 16282729 18949393 16524972 18288408 16331619 17016601 15148649 18448328 16303861 18383874
MESH:D015179 Colorectal Neoplasms Isoflavones 2.9317116718
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D007644 Darier Disease Fluorouracil 4.8416733453
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 4.0716823706 15059100 11298694
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8016285004
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3517107852
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 3.8415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D004714 Endometrial Hyperplasia Genistein 4.6416402032
MESH:D016889 Endometrial Neoplasms Genistein 3.3811473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.5115173087 16785472 16337965 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Cyclosporine 2.8819224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Cyclosporine 8.6212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D005909 Glioblastoma Genistein 3.2816598420
MESH:D005910 Glioma Fluorouracil 2.8816145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4018337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4910048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9315340226 12621046 16120746
MESH:D019584 Hot Flashes Isoflavones 5.0414716179 17290160
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1116354765 8697196 16959395 15340226 18606429
MESH:D006973 Hypertension Cobalt 8.7817039479
MESH:D006973 Hypertension Cyclosporine 8.7810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.7818670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712200463 12878042
MESH:D007333 Insulin Resistance Sodium Selenite 3.2914714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Cyclosporine 2.358314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 7.4712371664
MESH:D007680 Kidney Neoplasms Fluorouracil 7.4716985049
MESH:D007938 Leukemia Genistein 3.0417468513 18980019
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.4117823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4112878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.799163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.7921137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 10.7916603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.868603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8612151625
MESH:D008173 Lung Diseases, Obstructive Cobalt 5.906434250
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0617365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.8614755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8618816296 20135361 18569708 20869020 20464547 18520028 6695378 17053015 20064080
MESH:D008175 Lung Neoplasms Fluorouracil 4.8615246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8619555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8415086387
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0914737004
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.9612929590 14578162
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1916166281 16966607 18303189
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.6016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.6016757204 18986760
MESH:D009203 Myocardial Infarction Genistein 2.8717141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.6817141266
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1111141357
MESH:D009369 Neoplasms Fluorouracil 5.1118600527 18239605 16928823
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009421 Nervous System Malformations Genistein 9.7316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7314600291
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4516436463
MESH:D010024 Osteoporosis Genistein 7.6519401787
MESH:D010024 Osteoporosis Isoflavones 7.6516562857
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1216169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6119005980
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6716929163 15113037 19003803 16500647
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9310923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8818626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 1.8816925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Isoflavones 1.8817374662 17571952 16365062 17219775
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8818760546
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 6.3417365031 15814490 17322281 17975199
MESH:D011658 Pulmonary Fibrosis Cobalt 6.346434250
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0418722050 15538739 16160472 18286688
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5110029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5116192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.432093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4318396642 15786421 16424979 17172411 17522103 18567086 16951190 19084572 19015929 17498489
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0216280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1917053015
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9016803524
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
KEGG:04810 Regulation of actin cytoskeleton
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29911
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449748gemcitabine
    PA449177cytarabine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved