AutismKB 2.0

Annotation Detail for ADCY2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ADCY2 ( AC2,FLJ16822,FLJ45092,HBAC2,KIAA1060,MGC133314 )
Gene Full Name: adenylate cyclase 2 (brain)
Band: 5p15.31
Quick LinksEntrez ID:108; OMIM: 103071; Uniprot ID:ADCY2_HUMAN; ENSEMBL ID: ENSG00000078295; HGNC ID: 233
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04020Calcium signaling pathway
hsa05414Dilated cardiomyopathy
hsa04540Gap junction
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa00230Purine metabolism
hsa04971Gastric acid secretion
hsa04114Oocyte meiosis
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Transmembrane transport of small molecules
Opioid Signalling
Integration of energy metabolism
Pathway IDPathway Name
200036LPA4-mediated signaling events
200004Endothelins
200011LPA receptor mediated events
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P04379Beta3 adrenergic receptor signaling pathway
P04377Beta1 adrenergic receptor signaling pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00019Endothelin signaling pathway
P04386Histamine H2 receptor mediated signaling pathway
P043765HT4 type receptor mediated signaling pathway
P05731GABA-B receptor II signaling
P043735HT1 type receptor mediated signaling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ADCY2 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADCY2 mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADCY2 mRNAaffects cotreatment|decreases expression 20360939
D002220 Carbamazepine Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY2 protein]affects binding|decreases reaction|increases activity 19922557
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of ADCY2 mRNAaffects cotreatment|increases expression 18636392
D003976 Diazinon Diazinon results in decreased expression of ADCY2 mRNAdecreases expression 17452286
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADCY2 mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY2 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of ADCY2 mRNAincreases expression 18035473
D007657 Ketone Bodies Ketone Bodies results in increased expression of ADCY2 mRNAincreases expression 16807920
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of ADCY2 mRNAaffects cotreatment|increases expression 18636392
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ADCY2 mRNAaffects binding|decreases expression|increases activity 19710929
D020849 Raloxifene Raloxifene affects the expression of ADCY2 mRNAaffects expression 16079270
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of ADCY2 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in decreased expression of ADCY2 mRNAdecreases expression 19244175
C071262 SK&F 82958 Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY2 protein]affects binding|decreases reaction|increases activity 19922557
C071262 SK&F 82958 [SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY2 proteinaffects binding|increases activity 19922557
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADCY2 mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of ADCY2 mRNAaffects cotreatment|increases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 8.678986270
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.6714514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D055371 Acute Lung Injury Chlorine 9.0920601635
MESH:D055371 Acute Lung Injury pirinixic acid 9.0918653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8114692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.633712494
MESH:D000236 Adenoma Diethylnitrosamine 6.636695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.2419052882 17620307 18056438 19061943 17162532 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.2416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.2416835633
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.3316487989
MESH:D000419 Albuminuria Raloxifene 4.5817451421 17308373
MESH:D000544 Alzheimer Disease Ozone 4.3615513908
MESH:D000544 Alzheimer Disease Raloxifene 4.3615800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 2.6317854713 16373670
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0211289319 1440618
MESH:D001714 Bipolar Disorder Carbamazepine 4.1217594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001930 Brain Injuries Raloxifene 4.4616580743
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8817474063
MESH:D001943 Breast Neoplasms Raloxifene 1.8817440819 16912660 17049068 16837676 17952589 17595753 15572757 17242785 17261762 15775269 17893378 15758505
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6618417511 19059883 16777450 17626835 15516495 18315731 14754758
MESH:D002100 Cachexia Ozone 4.7316183385
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9216050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.987296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9818665156 17978847 20514400 18785209 16328049 11831363 19383236 17138121 17162532 19394651 18494052 19701751 16878318 20524982 18971187 21159647 20101231 16288022 18691550 16779866 18056438 18506893 20512989 17428255 10737359 19335982 19418558 16830150 20432363 19822196 18978308 16807293 19107877 16540662 18788625 19539802 16502159 19519916 16681979 20935162 10672840 19171122 3084413 20007298 19919837 20084675 16569478 16698587 19052882 17173139 18210153 3581430 20727157 17055752 18393292 19208518 17761372 16935385 20214788
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.667296757
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.0517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4315775269
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.647505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.642727394 21159647 7505956 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.2819486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 13.2817333356 16105132 17110522 15861022 11677210 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 13.2819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.098697196 15668235 12621046 15340226 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.6015800139
MESH:D003092 Colitis Selenium 3.7717936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D019465 Craniofacial Abnormalities Carbamazepine 3.909014606
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.9019769572
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1417474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7911906362 11298694 14531868 8970840 2524372 18759878 12868966 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.473621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D003928 Diabetic Nephropathies Raloxifene 3.9217308373 17451421 15920148
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.4311748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.3916538176 20216337 15057820 16538175
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.986679447 18289764 8291058 9328219 18692083 7440962 11289319 1440618 18648102 16192314 9022650 9653073 6482804
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 11.9817465707
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.9819107877
MESH:D056486 Drug-Induced Liver Injury Selenium 11.9815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.9820420201
MESH:D004362 Drug Toxicity Carbamazepine 8.3520216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3511462148
MESH:D004417 Dyspnea Chlorine 10.6820016425
MESH:D004417 Dyspnea Diazinon 10.6816487989
MESH:C538011 Eales disease Vitamin E 4.709068938
MESH:D004487 Edema pirinixic acid 11.3212083418
MESH:D004487 Edema Raloxifene 11.3215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.3211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 15.4317654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.4312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 15.4315845917
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.2416538176 19915237 18855540 20485159 16415921
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.2017275665
MESH:D004828 Epilepsies, Partial Carbamazepine 4.9715008574 16628512 17116037
MESH:D004827 Epilepsy Carbamazepine 3.989014606 821787 19439326 7988514 19620853 17465707 19700373 18234410 20417680 17178248
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 5.113659116 15276670
MESH:D004916 Erythromelalgia Carbamazepine 5.7119549232
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1216302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.103581430
MESH:D005076 Exanthema Carbamazepine 5.4620485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Diethylnitrosamine 18.6321071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.6315345470
MESH:D005234 Fatty Liver pirinixic acid 18.6320131406 19236843
MESH:D005234 Fatty Liver Raloxifene 18.6317473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.026705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9320067830
MESH:D005739 Gas Poisoning Chlorine 5.0120016425
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.027505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5310048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.5316080930
MESH:D006331 Heart Diseases Raloxifene 3.5211110106
MESH:D006333 Heart Failure pirinixic acid 6.9120558911
MESH:D006333 Heart Failure Selenium 6.9117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.536705139
MESH:D006505 Hepatitis Diazinon 9.5316487989
MESH:D006529 Hepatomegaly pirinixic acid 8.2219176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2212621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6916490937 16863852
MESH:D019584 Hot Flashes Vitamin E 3.9714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0515340226 18606429 16354765 16959395 8697196
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.7110459572
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 11.0815034207
MESH:D006965 Hyperplasia Carbamazepine 11.0818773962
MESH:D006973 Hypertension Raloxifene 5.2017577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2018850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Diazinon 6.9012948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9017937319
MESH:D007249 Inflammation Diethylnitrosamine 8.2418785209
MESH:D007249 Inflammation Flavonoids 8.2417296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2412878042 12200463
MESH:D007251 Influenza, Human Selenium 10.9616624496
MESH:D007251 Influenza, Human Vitamin E 10.9616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6216306350
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.5710783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.028074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.4215369732
MESH:D007674 Kidney Diseases Vitamin E 6.4212488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8716518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.956582329
MESH:D007889 Leiomyoma Raloxifene 4.4816973256
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.9816766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8118522880 19638242 18665156 20032147 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.3916169303
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0917034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.292862719 20405173 18978307 19638242 2422723 12112319 20434301 20583210 21071580 16942905 15885732 10737359 20118626 19833225 19642983 19073162 19850985 21278145 21167192 19690152 20501860 19499222 19551842 19427195 19090486 20137499 18644402 19255062 18754104 19256749 20101389 21047994 18977376 19996281 18648771 9163691 15175105 12771043 20452335 20492335 19254457 19426721 19812893 19294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.2916377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.2916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.71598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.7119004024 18775883 19539802 18079962 17174075 18544905 2563599 18093689 21159647 19126423 18308698 18282651 17854601 3124819 16267830 18164116 16842330 18253720 19009564 17942915 9362446 19519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7112151625
MESH:D008171 Lung Diseases Ozone 7.478266340 19066396
MESH:D008171 Lung Diseases Vitamin E 7.4716863852
MESH:D055370 Lung Injury Ozone 3.8320417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8320970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Ozone 4.838597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8311884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 4.8311062179
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5616628512
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7515318939
MESH:D008607 Mental Retardation Carbamazepine 3.729014606
MESH:D008654 Mesothelioma Selenium 2.7815107826
MESH:D008679 Metaplasia Ozone 5.1110496685
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5515863610
MESH:D009101 Multiple Myeloma Raloxifene 3.4216497877
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009224 Myotonia Congenita Carbamazepine 5.4620399394
MESH:D009232 Myxoma Raloxifene 5.5516343187
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.673581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.679029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.9417405874
MESH:D009421 Nervous System Malformations Carbamazepine 9.8716990009
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.906679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1220387270
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.404026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.023988306
MESH:D010018 Osteomalacia Carbamazepine 5.4617016548
MESH:D010024 Osteoporosis Raloxifene 3.3819059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2115579764 15758505 17823083 17893378
MESH:D010146 Pain Carbamazepine 4.0215215642
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4116540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.477296757
MESH:D010267 Parapsoriasis Carbamazepine 5.6916538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.9217145499 17679678
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010538 Peritonitis Ozone 4.1216369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.476228378
MESH:D010954 Plasmacytoma Selenium 4.8915087411
MESH:D011014 Pneumonia Ozone 4.3918929643 18007984 18381685
MESH:D011041 Poisoning Diazinon 4.3317603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.532563599
MESH:D011248 Pregnancy Complications Carbamazepine 5.149014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 9.829014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8211399792 11222880 11896295 11118676
MESH:D011471 Prostatic Neoplasms Raloxifene 3.4316536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Vitamin E 3.4315084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D019310 Pseudolymphoma Carbamazepine 5.6012752131 9591791
MESH:D011693 Purpura Raloxifene 5.5515770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D012120 Respiration Disorders Chlorine 5.2118579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.363692021
MESH:D012640 Seizures Carbamazepine 3.7816180713 9046859 9844417 16876388 16938433 19414003 15946322
MESH:D012871 Skin Diseases Vitamin E 2.4418709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0316192470
MESH:D012893 Sleep Disorders Carbamazepine 5.1119414003
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9416709447
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.2016538176 20485159 15057820 16415921 18855540 19915237 19694795
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D020521 Stroke Raloxifene 8.6516837676
MESH:D020521 Stroke Vitamin E 8.6516517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.067505956 1399818 6582329 6587162 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.067505956
MESH:D013978 Tibial Fractures Raloxifene 5.2119048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.178074119
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.1717572228
MESH:D014570 Urologic Diseases Diazinon 5.2816487989
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2116837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
Pathway ID Pathway Name
KEGG:04976 Bile secretion
KEGG:04020 Calcium signaling pathway
KEGG:04062 Chemokine signaling pathway
KEGG:05414 Dilated cardiomyopathy
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:04724 Glutamatergic synapse
KEGG:04912 GnRH signaling pathway
REACT:1505 Integration of energy metabolism
KEGG:04916 Melanogenesis
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
KEGG:04972 Pancreatic secretion
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:00230 Purine metabolism
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24561
    • No data
    No data
    Releated drug ID Related drug Name
    PA165290926fluticasone/salmeterol
    PA451300salmeterol
    PA164749238exenatide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02587 - Forskolin
    DB06843 - 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved