AutismKB 2.0

Annotation Detail for SEPT9


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SEPT9 ( AF17q25,FLJ75490,KIAA0991,MSF,MSF1,NAPB,PNUTL4,SINT1,SeptD1 )
Gene Full Name: septin 9
Band: 17q25.3
Quick LinksEntrez ID:10801; OMIM: 604061; Uniprot ID:SEPT9_HUMAN; ENSEMBL ID: ENSG00000184640; HGNC ID: 7323
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2213Adenocarcinoma, Mucinous
2167Neuritis
No data
No data
Desease Name
Ovarian carcinoma
Leukemia, acute myeloid, therapy-related
Amyotrophy, hereditary neuralgic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SEPT9 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SEPT9 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SEPT9 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of SEPT9 mRNAaffects expression 18414638
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SEPT9 proteindecreases expression 20097212
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SEPT9 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SEPT9 mRNAincreases expression 15003993
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of SEPT9 proteinincreases expression 20935162
D004052 Diethylnitrosamine [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of SEPT9 proteinaffects cotreatment|increases expression 20935162
D010634 Phenobarbital [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of SEPT9 proteinaffects cotreatment|increases expression 20935162
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.726195326
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 7.006695378
MESH:D000236 Adenoma Diethylnitrosamine 7.006695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.2419052882 19061943 17162532 16434500 17620307 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2417620307
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5317306315
OMIM:162100 AMYOTROPHY, HEREDITARY NEURALGIC marker/mechanism
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D020261 Arsenic Poisoning Arsenic 2.9112569548 16835338 18414634 16251483
MESH:D050197 Atherosclerosis Arsenic 3.3612928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D020968 Brachial Plexus Neuritis marker/mechanism 17546647
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0717474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0717474063
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6917687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.1816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.183084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 9.1816507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.1819919837 16502159 17428255 21159647 16569478 3581430 20512989 16779866 17055752 16807293 16540662 17138121 16681979 18393292 16830150 19539802 18665156 18785209 20101231 17761372 18971187 17978847 19519916 17173139 20432363 16288022 17162532 19701751 20214788 16878318 19383236 19208518 19107877 19335982 16698587 18506893 19418558 20524982 18494052 20727157 20935162 19822196 20084675 18788625 16935385 3084413 10672840 20007298 18056438 19394651 18978308 20514400 18691550 19052882 10737359 16328049 11831363 19171122 18210153
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.1820935162 20007298 1701930 17173139 6705139
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.8815504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8820419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2718640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5815738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4918022660 16973168
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.996135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9920889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.997505956 17174075 2727394 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4917562736 18713872 19370779 12705907 12594235 17906064 16485898 19739265 16227642 12153990 11529661 18071297 12392966 10663392 16393943 15968718 19420014 16177239 17522070 11461765 12540782 16781746 14986274 19416960 16109766 14725611 15619225 10915739 11739529 19085960 11421492 16081117 19923254 11287661 12958197 19164858 14550746 11743745 11834606 2444490 10774834
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4919107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.1911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5016530937
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3920387270 21071580
MESH:D005534 Foot Diseases Arsenic 5.886392382
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006529 Hepatomegaly Phenobarbital 3.7416109766
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6517050553
MESH:D006973 Hypertension Arsenic 2.9316076760 9931084 11953799
MESH:D006987 Hypesthesia Arsenic 5.8816093927
MESH:D007249 Inflammation Diethylnitrosamine 2.4718785209
MESH:D007642 Keratosis Arsenic 5.2816930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1516705839
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6817339181
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9918522880 18665156 20032147 18407596 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 6.9921047994
MESH:D008107 Liver Diseases Acetaminophen 9.7919014921 12969438 16610002 16611625 12587719 19784758 11587558 19460945
MESH:D008107 Liver Diseases Arsenic 9.7911134558
MESH:D008107 Liver Diseases Diethylnitrosamine 9.7917034775
MESH:D008107 Liver Diseases Phenobarbital 9.7919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.997678174
MESH:D008113 Liver Neoplasms Arsenic 14.9916368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.9920195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.9921278145 19090486 19294768 19833225 20452335 19642983 16942905 21071580 18648771 19256749 12112319 20101389 19499222 19255062 19812893 20405173 20137499 19551842 19638242 20492335 19690152 15885732 19427195 2422723 21047994 21167192 12771043 20434301 15175105 20118626 18644402 18978307 19073162 20501860 18754104 10737359 19426721 19850985 19254457 19996281 2862719 20583210 9163691 18977376
MESH:D008113 Liver Neoplasms Phenobarbital 14.9921047994 15975961 19482888 8742319 19812893 19073162
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.586135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.5819126423 19519916 19009564 9362446 18253720 2563599 18544905 17174075 18079962 19004024 17942915 16842330 19539802 21159647 18775883 18282651 16267830 17854601 3124819 18093689 18164116 18308698
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.5818308698 17172636 2563599 1399818 6150874
MESH:D008175 Lung Neoplasms Arsenic 3.5817976673 19168569 17306315
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5820464547 18520028 20064080 17053015 20869020 18816296 18569708 6695378 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5820970405 6695378 21163286 20512841
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D017202 Myocardial Ischemia Arsenic 4.1515371236
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.157678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.649029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2511141357
MESH:D009436 Neural Tube Defects Arsenic 3.5816620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.6017056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6216049721
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010051 Ovarian Neoplasms Arsenic 2.8017306315
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4716540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4716965848
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.2816905509 6392382 15371236
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.712563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.712563599
MESH:D011471 Prostatic Neoplasms Arsenic 3.2516140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2517292933
MESH:D011507 Proteinuria Arsenic 4.2221343184
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3818551238
MESH:D012640 Seizures Phenobarbital 6.3811442880 16876388 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D012871 Skin Diseases Arsenic 2.7917548696 16353154 17938729 16702368 19834688 6392382 17050553 16759981 15952646 17453740 18709164
MESH:D012878 Skin Neoplasms Arsenic 10.0317976673 17050553 17029826 15504454 16251483 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.0310029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 10.038532709
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3718456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.707505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.701399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7516049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.7519322015 18640142 11144890 17306315 15987713 19429237 17976673
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7517053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014652 Vascular Diseases Arsenic 5.0217056641
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31132
    • No data
    Releated disease ID Related disease Name
    PA446108Colorectal Neoplasms
    PA447131Brachial Plexus Neuritis
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved