AutismKB 2.0

Annotation Detail for SDCCAG8


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Basic Information Top
Gene Symbol:SDCCAG8 ( CCCAP,NY-CO-8,hCCCAP )
Gene Full Name: serologically defined colon cancer antigen 8
Band: 1q43-q44
Quick LinksEntrez ID:10806; OMIM: 613524; Uniprot ID:SDCG8_HUMAN; ENSEMBL ID: ENSG00000054282; HGNC ID: 10671
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Cell Cycle, Mitotic
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No data
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SDCCAG8 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SDCCAG8 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SDCCAG8 mRNAdecreases expression 20064835
D005472 Fluorouracil Fluorouracil results in increased expression of SDCCAG8 mRNAincreases expression 16510598
D015741 Metribolone Metribolone results in increased expression of SDCCAG8 mRNAincreases expression 17010196
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SDCCAG8 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SDCCAG8 mRNAaffects binding|increases activity|increases expression 19710929
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of SDCCAG8 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of SDCCAG8 mRNAdecreases expression 19244175
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of SDCCAG8 mRNAdecreases expression 16330358
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of SDCCAG8 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of SDCCAG8 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5520127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.5517638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.963712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.966695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000740 Anemia Fluorouracil 3.9017963324 15504547 16511603
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1620146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.1618608205 15136595 16110121 19217205 16557594 16595493 18357371
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 3.7317121937
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.163581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.1616332177 17088986 17045692 18930000 17971768 16799960
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.787296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.7818695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8120419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8116280240 16757204 18986760 17066447
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.897505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.359022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617287894 15001691 17018589 16510598 16340194 17725105 17172411 17169374 18772588 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018288408 18448328 15289873 16282729 17094418 17695437 17594712 18802399 18949393 20501625 17255274 16303861 17016601 16524972 14970324 18509181 16331619 15148649 17401013 17454858 18383874 16391804
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0611298694 11906362 8970840 8156756 18759878 12868966 2524372 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.5416684804
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.101440618 18648102 6679447 9022650 18692083 6482804 9328219 16192314 8291058 18289764 9653073 7440962 11289319
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1015131321
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.503581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.5016530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.5015173087 17638652 16337965 16785472 16481741
MESH:D005234 Fatty Liver pirinixic acid 2.9719236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5218337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.0220471113
MESH:D006330 Heart Defects, Congenital Vitamin E 7.0216080930
MESH:D006333 Heart Failure pirinixic acid 7.3520558911
MESH:D006333 Heart Failure Selenium 7.3517162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly pirinixic acid 3.2518467677 19176532 16221962 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D007251 Influenza, Human Selenium 12.0416624496
MESH:D007251 Influenza, Human Vitamin E 12.0416624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007674 Kidney Diseases Vitamin E 2.9112488133
MESH:D052177 Kidney Diseases, Cystic marker/mechanism 20835237
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.066582329
MESH:D007680 Kidney Neoplasms Fluorouracil 8.0616985049
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4316169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8120195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 7.8117045692 16603448 18383874 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 7.8120007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.656587162 3712494 598648 1399818
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5720064080 18816296 17053015 20464547 20869020 18520028 6695378 18569708 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 3.5715246190
MESH:D008175 Lung Neoplasms Vitamin E 3.5711062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.0616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.0618986760 16757204
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.7611141357
MESH:D009369 Neoplasms Fluorouracil 8.7618600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 8.7617405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.614026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7219003803 16929163 15113037 16500647
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5317292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5318626508 19082440
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5315084515
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1916160472 18722050 15538739 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012164 Retinal Diseases marker/mechanism 20835237
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.462093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4616424979 17498489 18396642 18567086 16951190 19084572 17522103 15786421 19015929 17172411
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.041399818 6582329 6587162 3712494 7505956
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.208074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2017053015
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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