AutismKB 2.0

Annotation Detail for CPLX2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CPLX2 ( 921-L,CPX-2,CPX2,Hfb1,MGC138492 )
Gene Full Name: complexin 2
Band: 5q35.2
Quick LinksEntrez ID:10814; OMIM: 605033; Uniprot ID:CPLX2_HUMAN; ENSEMBL ID: ENSG00000145920; HGNC ID: 2310
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2069Schizophrenia
2221Behavior disease
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D020106 Acrylamide Acrylamide binds to and affects the metabolism of CPLX2 proteinaffects binding|affects metabolic processing 17698512
C000188 alachlor alachlor results in increased expression of CPLX2 mRNAincreases expression 12419858
D000638 Amiodarone Amiodarone results in increased expression of CPLX2 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CPLX2 mRNAaffects expression 16483693
D003024 Clozapine Clozapine results in decreased expression of CPLX2 mRNAdecreases expression 17266109
D007657 Ketone Bodies Ketone Bodies results in decreased expression of CPLX2 mRNAdecreases expression 16807920
C030667 methylazoxymethanol methylazoxymethanol results in increased expression of CPLX2 mRNAincreases expression 17107856
D010622 Phencyclidine Phencyclidine results in decreased expression of CPLX2 mRNAdecreases expression 17266109
D024505 Tocopherols Tocopherols results in increased expression of CPLX2 mRNAincreases expression 17654050
C025643 vinclozolin vinclozolin affects the expression of CPLX2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000380 Agranulocytosis Clozapine 5.2714617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases alachlor 4.8911874814 14769641
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9618218290 18057881 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 4.0318651412 19698954
MESH:D001714 Bipolar Disorder marker/mechanism 14708030
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.0719483382
MESH:D001943 Breast Neoplasms Acrylamide 3.5816253758 18183576
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9415710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.3218974383
MESH:D002418 Cattle Diseases Acrylamide 5.7212510666
MESH:D003072 Cognition Disorders Clozapine 5.1817123785
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D017449 Dermatitis, Allergic Contact alachlor 4.408428444
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.0116402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.8215331141
MESH:D056486 Drug-Induced Liver Injury Amiodarone 2.4315265979 18218290
MESH:D050171 Dyslipidemias Clozapine 4.3016402076
MESH:D005234 Fatty Liver Amiodarone 3.6914986274
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D006529 Hepatomegaly Amiodarone 3.9615265979
MESH:D006937 Hypercholesterolemia Amiodarone 4.049751232 8137927
MESH:D006948 Hyperkinesis Clozapine 5.1516046005
MESH:D007037 Hypothyroidism Amiodarone 4.7317991464 18020914
MESH:D007247 Infertility, Female Acrylamide 5.3911020651
MESH:D007248 Infertility, Male Acrylamide 12.2515355880 12507653 15749267 11020651
MESH:D007248 Infertility, Male alachlor 12.2516466525 17049205 12948887
MESH:D007248 Infertility, Male vinclozolin 12.2516467254
MESH:D007938 Leukemia alachlor 4.0914769641
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008064 Lipidoses Amiodarone 8.6215342952 17567588
MESH:D008064 Lipidoses Clozapine 8.6217567588
MESH:D008133 Long QT Syndrome Amiodarone 3.7117391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.4812587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.7418516814
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 4.1817927505
MESH:D001523 Mental Disorders Clozapine 4.1816856516
MESH:D008654 Mesothelioma Tocopherols 4.1615878867
MESH:D024821 Metabolic Syndrome X Clozapine 4.5619142101
MESH:D009101 Multiple Myeloma alachlor 4.4014769641
MESH:D009181 Mycoses Amiodarone 5.1712754197 17974566
MESH:D009410 Nerve Degeneration Acrylamide 4.8211264303 12387367 12387366
MESH:D009422 Nervous System Diseases Acrylamide 5.1412164553 12507653
MESH:D009669 Nose Neoplasms alachlor 5.0614563481 15580706 16698726 11127290 16178123
MESH:D009765 Obesity Clozapine 3.0519142110 18515891
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 5.3111510240
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1318220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms Tocopherols 4.5712504091
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011618 Psychotic Disorders marker/mechanism 14708030
MESH:D011618 Psychotic Disorders Clozapine 4.3015331141
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9112832656 12490602 11597910
MESH:D012135 Respiratory Sounds alachlor 5.1611874814
MESH:D012559 Schizophrenia marker/mechanism 11483314 14708030
MESH:D012559 Schizophrenia Clozapine 2.7517667964 11763009 18855531 20580759 20168265 17726453 20107430 11151749 16141801 19369910 20521326 20521320 20452607 18806925 17123785
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.3218724381
MESH:D013276 Stomach Ulcer Amiodarone 3.4818087811
MESH:D013610 Tachycardia Amiodarone 4.4911238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3919225199
MESH:D013733 Testicular Diseases Acrylamide 5.4715864552
MESH:D013959 Thyroid Diseases Amiodarone 5.0219731979
MESH:D013964 Thyroid Neoplasms alachlor 4.408812207
MESH:D013971 Thyrotoxicosis Amiodarone 5.0819584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.4317467628 11989578
MESH:D015430 Weight Gain Clozapine 4.6217502770 16141801 20107430 16402076 20564506 20521320
MESH:D015431 Weight Loss Clozapine 5.3117933447
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved