AutismKB 2.0

Annotation Detail for CPLX1


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Basic Information Top
Gene Symbol:CPLX1 ( CPX-I,CPX1 )
Gene Full Name: complexin 1
Band: 4p16.3
Quick LinksEntrez ID:10815; OMIM: 605032; Uniprot ID:CPLX1_HUMAN; ENSEMBL ID: ENSG00000168993; HGNC ID: 2309
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Synaptic Transmission
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Pathway IDPathway Name
500153Acetylcholine Neurotransmitter Release Cycle
500147Neurotransmitter Release Cycle
500148Norepinephrine Neurotransmitter Release Cycle
500149Serotonin Neurotransmitter Release Cycle
500151Dopamine Neurotransmitter Release Cycle
500150Glutamate Neurotransmitter Release Cycle
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2221Behavior disease
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006780 bisphenol A bisphenol A results in decreased expression of CPLX1 mRNAdecreases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in decreased expression of CPLX1 mRNA]affects reaction|decreases expression 17706920
D008344 Maneb [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 mRNAaffects cotreatment|decreases expression 17532186
D008344 Maneb [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 proteinaffects cotreatment|decreases expression 17532186
D010269 Paraquat [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 mRNAaffects cotreatment|decreases expression 17532186
D010269 Paraquat [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 proteinaffects cotreatment|decreases expression 17532186
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in decreased expression of CPLX1 mRNAdecreases expression 16221955
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CPLX1 mRNAdecreases expression 19465110
D024505 Tocopherols Tocopherols results in increased expression of CPLX1 mRNAincreases expression 17654050
C025643 vinclozolin vinclozolin affects the expression of CPLX1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Maneb 10.32982313
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.3214514962 15322242 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000382 Agricultural Workers' Diseases Maneb 10.668807224
MESH:D000382 Agricultural Workers' Diseases Paraquat 10.6611874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001008 Anxiety Disorders vinclozolin 3.8619015723
MESH:D001714 Bipolar Disorder marker/mechanism 14708030
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001943 Breast Neoplasms bisphenol A 2.0317123778
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2012621046 8697196 16354765 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.6714966744
MESH:D017449 Dermatitis, Allergic Contact Maneb 5.168807224
MESH:D009783 Dermatitis, Occupational Maneb 6.328807224
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.7416417039
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 4.4317162496
MESH:D005911 Gliosis Maneb 15.9611124998
MESH:D005911 Gliosis Paraquat 15.9611124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2516120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4918606429 8697196 16959395 15340226 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007248 Infertility, Male Paraquat 7.534850670
MESH:D007248 Infertility, Male vinclozolin 7.5316467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 3.4616393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1316417039
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 4.2417927505
MESH:D008654 Mesothelioma Tocopherols 4.2015878867
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009410 Nerve Degeneration Maneb 9.8516893418 15350641
MESH:D009410 Nerve Degeneration Paraquat 9.8516893418
MESH:D009421 Nervous System Malformations bisphenol A 10.7011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.7014600291
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D010300 Parkinson Disease Maneb 6.3716510128 11124998 16140633 12911755 15824117
MESH:D010300 Parkinson Disease Paraquat 6.3716140633 11181820 16510128 12911755 11445065 11124998 15451049 15824117
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.7916190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D011014 Pneumonia Paraquat 4.8512504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 18.7110548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 18.7111118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 18.7118220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.3318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.7616740699
MESH:D011471 Prostatic Neoplasms Tocopherols 3.7612504091
MESH:D011472 Prostatitis vinclozolin 5.3318629315
MESH:D011618 Psychotic Disorders marker/mechanism 14708030
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D011658 Pulmonary Fibrosis Paraquat 3.0017997886 16324872
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.2111700416
MESH:D012135 Respiratory Sounds Paraquat 4.4111874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012162 Retinal Degeneration Paraquat 4.0716458197
MESH:D012559 Schizophrenia marker/mechanism 14708030
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D014591 Uterine Diseases bisphenol A 5.4514652134
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26826
    • No data
    No data
    Releated drug ID Related drug Name
    PA451898vitamin c
    PA10090l-glutamine
    PA450197l-leucine
    PA448976choline
    PA449396dopamine
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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