AutismKB 2.0

Annotation Detail for ALDH1L1


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Basic Information Top
Gene Symbol:ALDH1L1 ( 10-fTHF,DKFZp781N0997,FTHFD )
Gene Full Name: aldehyde dehydrogenase 1 family, member L1
Band: 3q21.3
Quick LinksEntrez ID:10840; OMIM: 600249; Uniprot ID:FTHFD_HUMAN; ENSEMBL ID: ENSG00000144908; HGNC ID: 3978
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00670One carbon pool by folate
No data
No data
Pathway IDPathway Name
P043725-Hydroxytryptamine degredation
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
Desease Name
CANCER
breast cancer
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ALDH1L1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ALDH1L1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of ALDH1L1 mRNAaffects expression 21346803
C005984 5-methyltetrahydrofolate ALDH1L1 protein results in decreased abundance of 5-methyltetrahydrofolatedecreases abundance 16627483
D000082 Acetaminophen Acetaminophen affects the expression of ALDH1L1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ALDH1L1 proteinaffects expression 20106945
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of ALDH1L1 mRNAincreases expression 15912405
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ALDH1L1 mRNAaffects expression 17109383
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ALDH1L1 proteinaffects expression 17109383
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ALDH1L1 proteindecreases expression 15650968
D002995 Clofibric Acid Clofibric Acid affects the expression of ALDH1L1 mRNAaffects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of ALDH1L1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of ALDH1L1 mRNAdecreases expression 18042831
D000431 Ethanol Ethanol results in decreased activity of ALDH1L1 proteindecreases activity 16385189
D000431 Ethanol Ethanol results in decreased expression of ALDH1L1 mRNAdecreases expression 17920746
D000431 Ethanol Folic Acid affects the reaction [Ethanol results in decreased activity of ALDH1L1 protein]affects reaction|decreases activity 16385189
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDH1L1 mRNAaffects cotreatment|increases expression 17942748
D005492 Folic Acid ALDH1L1 protein results in increased degradation of Folic Acidincreases degradation 16627483
D005492 Folic Acid Folic Acid affects the activity of ALDH1L1 proteinaffects activity 16385189
D005492 Folic Acid Folic Acid affects the reaction [Ethanol results in decreased activity of ALDH1L1 protein]affects reaction|decreases activity 16385189
C029424 hydrazine hydrazine results in decreased expression of ALDH1L1 proteindecreases expression 15370871
C041786 palm oil palm oil results in decreased expression of ALDH1L1 mRNAdecreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of ALDH1L1 mRNAdecreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of ALDH1L1 mRNA]decreases expression|increases reaction 18467677
D010795 Phthalic Acids Phthalic Acids results in decreased expression of ALDH1L1 mRNAdecreases expression 15728792
C006253 pirinixic acid pirinixic acid results in decreased expression of ALDH1L1 mRNAdecreases expression 17426115
D012643 Selenium Selenium affects the expression of ALDH1L1 proteinaffects expression 19351701
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ALDH1L1 mRNAaffects cotreatment|increases expression 17942748
D014303 Trinitrotoluene Trinitrotoluene affects the expression of ALDH1L1 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 19.337525203
MESH:D000014 Abnormalities, Drug-Induced Ethanol 19.3317676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 19.3314514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 19.337525203
MESH:D000138 Acidosis Ethanol 4.3711192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8117505938
MESH:D058186 Acute Kidney Injury Folic Acid 4.2117003819 16316344 16595132
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7814692618
MESH:D000236 Adenoma Folic Acid 3.7216963246
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.4616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.4616835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.1915451039 15451040
MESH:D000544 Alzheimer Disease Folic Acid 3.0217116317
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000799 Angioedema Acetaminophen 3.7110982225
MESH:D000853 Anophthalmos Ethanol 4.6915513904
MESH:D001008 Anxiety Disorders Ethanol 3.9011141031
MESH:D001161 Arteriosclerosis Dietary Fats 9.4715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.4711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5815885639
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.2720106747
MESH:D001321 Autistic Disorder 5-methyltetrahydrofolate 2.4818461502
MESH:D001321 Autistic Disorder Acetaminophen 2.4818445737
MESH:D001321 Autistic Disorder Folic Acid 2.4821388746
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Folic Acid 1.9616777985
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002056 Burns Ethanol 4.5216374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6516011737 16192424 18705752 3786805 16124888 16227642 16097048 10355542 15721981 15700767 15673190 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.1216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.1216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.123084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.1221507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.1218788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 11.1215289165 15763234 18788625
MESH:D006332 Cardiomegaly Ethanol 6.6119332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6116120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Folic Acid 3.8616755160
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 12.0414694615
MESH:D002386 Cataract Acetaminophen 12.0410977129
MESH:D002386 Cataract Trinitrotoluene 12.0415817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.276135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.2712371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002779 Cholestasis Cyclosporine 12.7819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.7817333356 11677210 15861022 16105132 17110522 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 12.7819176532
MESH:D002971 Cleft Lip Ethanol 7.6615513904
MESH:D002971 Cleft Lip Folic Acid 7.6621254359
MESH:D002972 Cleft Palate Ethanol 9.6515513904
MESH:D002972 Cleft Palate Folic Acid 9.658946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.658697196 15340226 16354765 12621046 15668235
MESH:D003092 Colitis Selenium 3.6517936198
MESH:D015179 Colorectal Neoplasms Folic Acid 2.7017087956 16985020 17245555 16963246 17116713
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 14.9515095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 14.9514669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 14.9515095906
MESH:D019465 Craniofacial Abnormalities Ethanol 2.5915451039 19302082 11198716 11873399 10194807 15513904 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5910048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 18.0518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 18.0518551238
MESH:D003490 Cyanosis Trinitrotoluene 18.0518551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.4616886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4617107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 25.2218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 25.2218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 25.2221346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 25.2215968718 10663392 14986274 14550746 19416960 10915739 18071297 11739529 11461765 11287661 11834606 19164858 16227642 11743745 17522070 12594235 14725611 12153990 11421492 19739265 16781746 12540782 12705907 18713872 10774834 17906064 17562736 11529661 2444490 19420014 19085960 16177239 16393943 16485898 19923254 12958197 19370779 16081117 16109766 12392966 15619225
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 25.223786805 6884620 15027814 10092053 11566570 7440962 7120509 10915739 16227642 16177239 9327722 19085960 4309450 15968718 3732212 2869522 7179309 21278145 19336974 15998439 6623471 17522070
MESH:D056486 Drug-Induced Liver Injury Ethanol 25.2211566570
MESH:D056486 Drug-Induced Liver Injury Selenium 25.2215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 25.2220420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 25.2221346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3618367378
MESH:D004487 Edema perfluorooctanoic acid 10.7717259670 12083418
MESH:D004487 Edema pirinixic acid 10.7712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.7712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0612538720
MESH:D016889 Endometrial Neoplasms Folic Acid 3.9217301261
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.919294722 10568697
MESH:D004938 Esophageal Neoplasms Ethanol 2.7216704527
MESH:D017889 Exfoliation Syndrome Folic Acid 5.3616504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 29.1512795759 16239168 15959796 17595544 12631006 19224547 61145 16045604
MESH:D005234 Fatty Liver Cyclosporine 29.1519224547
MESH:D005234 Fatty Liver Dietary Fats 29.1517967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Ethanol 29.1519236843 16409862 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.1515345470
MESH:D005234 Fatty Liver pirinixic acid 29.1519236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.5417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.1715451040 16946407 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 20.0618705752
MESH:D005355 Fibrosis Cyclosporine 20.0612168785 12639820
MESH:D005355 Fibrosis Dietary Fats 20.0618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.0620067830
MESH:D005756 Gastritis Acetaminophen 18.3616983495
MESH:D005756 Gastritis Ethanol 18.3615046732
MESH:D005756 Gastritis Folic Acid 18.3617171786
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.098708960
MESH:D005901 Glaucoma Folic Acid 4.9516504073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006330 Heart Defects, Congenital Folic Acid 6.6416524890 17286298
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 6.6820558911
MESH:D006333 Heart Failure Selenium 6.6817162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4719900420 19110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 19.663609246
MESH:D006529 Hepatomegaly pirinixic acid 19.6616221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.6615340226 16120746 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 19.6615817613
MESH:D006679 HIV Seropositivity Folic Acid 5.3617209195
MESH:D006712 Homocystinuria 5-methyltetrahydrofolate 6.6917413090
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.928697196 16354765 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 12.5516870215
MESH:D006930 Hyperalgesia Ethanol 12.5518783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 12.5512083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4016899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.3816395265 16755160 16433478 16865747 16397167
MESH:D006949 Hyperlipidemias Dietary Fats 3.4921332399
MESH:D006973 Hypertension Cyclosporine 4.7810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7818850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6017937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.6012150543
MESH:D007249 Inflammation Dietary Fats 7.9820412841
MESH:D007249 Inflammation perfluorooctanoic acid 7.9812083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.9812200463 12878042
MESH:D007251 Influenza, Human Selenium 4.0716624496
MESH:D007333 Insulin Resistance Dietary Fats 6.9618457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 6.9616306350
MESH:D007569 Jaw Abnormalities Ethanol 9.7215513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.7216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3115604871
MESH:D007674 Kidney Diseases Acetaminophen 5.5512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.5518776723 10903974 8314463
MESH:D007676 Kidney Failure, Chronic Selenium 3.7616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.7412371664
MESH:D007859 Learning Disorders Ethanol 4.0815451040
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.108812269
MESH:D017880 Limb Deformities, Congenital Ethanol 3.7217676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.6811408273 17157831 11903743 16943688 17334410 17174718 16221502 21278145 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 10.6818296743
MESH:D008103 Liver Cirrhosis Ethanol 10.6815289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.9718295389
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 15650968
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.8215925388 17721639 12666154 15893842 15931870 18279442 14724832 16027843 11481614 18317297 17922224 15959796 12389079 18429990 14512876 18156304 16638106 14716833 18481824 18263696 18006644 18418968 18054572 16011737 14716496 17525996 17900296 16116963 20821823 12667390 17944888 17976157 14620537 17640975 18166357 12445421 17823541 15876570 16033810 12609069 16015684 18395095 17698563 18420326 15370692 13678700 15057751 18205269 18705752 15052691 16097048 17565644 12445418 15650968 18187930 10355542 17708605 15996030 18376398 17869086 17761835 16192424 17766677 12632512 15730626 16136751 18339082 17557913 17631135 18277467 12741479 18251166 12546737 18472332 15123356 18210741 15338365 15362042 14748882 18412020 17714472 15818738 18472094 17481882 12898905 15673190 12632514 18395914 12649538 16248980 12586293 12958196 17805973
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 4.8218166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8212878042
MESH:D008107 Liver Diseases Acetaminophen 6.4012969438 16611625 19014921 11587558 19460945 19784758 12587719 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.4016964402 17285989 15720792 16246199 15830285
MESH:D008107 Liver Diseases Folic Acid 6.4016877991
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.5217207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.0217185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.0216899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.167678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 21.1615890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.1619294768
MESH:D008113 Liver Neoplasms Clofibric Acid 21.1617602206
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 21.1614757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 21.1620007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.1616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.442876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.448603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.4412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.4412151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.2614755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2611884234 19555203
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3017718048
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.6815318939
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.5616832597
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4419513568
MESH:D008569 Memory Disorders Ethanol 4.0618411066 15451040
MESH:D008654 Mesothelioma Selenium 2.7415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8416411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 17.0318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 17.037678174 18551238
MESH:D009336 Necrosis Trinitrotoluene 17.0318551238
MESH:D009369 Neoplasms pirinixic acid 1.8917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1718481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0914600291
MESH:D009436 Neural Tube Defects 5-methyltetrahydrofolate 8.1517413090
MESH:D009436 Neural Tube Defects Folic Acid 8.1517438019
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7618514411
MESH:D009503 Neutropenia Folic Acid 4.3816322990
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.829802331
MESH:D009765 Obesity Dietary Fats 4.3216723640 17217161 18457598 20518802 11836018 18674790 20132043 21332399 19632207
MESH:D009765 Obesity pirinixic acid 4.3220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 20.6716049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 20.6716049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 20.6714694615
MESH:D009784 Occupational Diseases Trinitrotoluene 20.6717852074 14694615 12819281
MESH:D010146 Pain Acetaminophen 2.2916870215
MESH:D010190 Pancreatic Neoplasms Ethanol 2.9212384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D010954 Plasmacytoma Selenium 4.7615087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1112371664
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.2317132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.2311399792 11118676 11222880 11896295
MESH:D011537 Pruritus Ethinyl Estradiol 3.1816919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D051437 Renal Insufficiency Folic Acid 4.6515728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012559 Schizophrenia Folic Acid 2.8816641680
MESH:D012640 Seizures 2,4-dinitrotoluene 13.4018551238
MESH:D012640 Seizures 2,6-dinitrotoluene 13.4018551238
MESH:D012640 Seizures Ethanol 13.409754883
MESH:D012640 Seizures Trinitrotoluene 13.4018551238
MESH:D012871 Skin Diseases Folic Acid 3.2218709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8116709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.3616361298
MESH:D013163 Splenomegaly Trinitrotoluene 5.0715817613
MESH:D013274 Stomach Neoplasms Ethanol 2.9218456281
MESH:D013274 Stomach Neoplasms Folic Acid 2.9217171786
MESH:D013276 Stomach Ulcer Ethanol 3.419562338 11906479 9211565 17918041 17189318 16755016
MESH:D020521 Stroke Folic Acid 4.2216517955
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.149754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.8416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.8416049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.5510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.5510091137
MESH:D014581 Urticaria Acetaminophen 2.8510982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1714692618
MESH:D014605 Uveitis Cyclosporine 3.851336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D015430 Weight Gain Dietary Fats 3.6216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3117120751
Pathway ID Pathway Name
KEGG:00670 One carbon pool by folate
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28393
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00116 - Tetrahydrofolic acid Dietary supplement;Micronutrient
    DB03131 - Beta-Mercaptoethanol
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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