AutismKB 2.0

Annotation Detail for CLPX


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Basic Information Top
Gene Symbol:CLPX ( - )
Gene Full Name: ClpX caseinolytic peptidase X homolog (E. coli)
Band: 15q22.31
Quick LinksEntrez ID:10845; OMIM: NA; Uniprot ID:CLPX_HUMAN; ENSEMBL ID: ENSG00000166855; HGNC ID: 2088
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CLPX mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CLPX mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of CLPX mRNAaffects expression 17562736
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CLPX mRNAaffects cotreatment|decreases expression 18164116
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CLPX mRNAdecreases expression 19150397
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CLPX mRNAaffects cotreatment|decreases expression 18164116
D008694 Methamphetamine Methamphetamine results in increased expression of CLPX mRNAincreases expression 19149911
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CLPX mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of CLPX mRNAdecreases expression 19482888
19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CLPX mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of CLPX mRNAincreases expression 18445702
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CLPX mRNAdecreases expression 17101203
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.106195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1015322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.773712494
MESH:D000236 Adenoma beta-Naphthoflavone 11.7719389873
MESH:D000236 Adenoma Diethylnitrosamine 11.7710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 26.9917162532 16434500 18056438 19052882 17620307 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 26.9917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 26.9916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 26.9916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9517474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.127296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.123084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.1220935162 17173139 17761372 20514400 20524982 17055752 18785209 16540662 18210153 16328049 18393292 19701751 17428255 20214788 16807293 16878318 19519916 18788625 19394651 16698587 20084675 18506893 19052882 19208518 3084413 16935385 20432363 20727157 18494052 19539802 16779866 10672840 18971187 17978847 21159647 19919837 3581430 16569478 19418558 16288022 20512989 17138121 18665156 19171122 19335982 16502159 10737359 16830150 19822196 20007298 19107877 19383236 18978308 17162532 20101231 18056438 16681979 18691550 11831363
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.1217173139 1701930 20935162 20007298 6705139
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.867505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.8620889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.8617174075 7505956 2727394 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.8419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.8416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.2719486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.2719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615340226 8697196 12621046 16354765 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.012524372 12868966 11298694 11906362 8970840 8156756 14531868 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3417107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.5011289319 6679447 6482804 9328219 9022650 18692083 7440962 18648102 16192314 18289764 8291058 9653073 1440618
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5011421492 14986274 16393943 11287661 10774834 16177239 12392966 19416960 16485898 11834606 19370779 16109766 15968718 18071297 17562736 11461765 17522070 16227642 11743745 19739265 11739529 10915739 10663392 16081117 19420014 14725611 19923254 12958197 18713872 16781746 12594235 19085960 19164858 12705907 2444490 11529661 14550746 15619225 12153990 17906064 12540782
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.5019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004421 Dystonia Phenobarbital 4.191851702
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1716714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.323659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.143922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.263659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.513581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Diethylnitrosamine 8.2620387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 8.2620131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly Phenobarbital 15.6916109766
MESH:D006529 Hepatomegaly pirinixic acid 15.6919176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.6915340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 15340226 16959395 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006948 Hyperkinesis Methamphetamine 5.7417658665
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
MESH:D007249 Inflammation Diethylnitrosamine 5.1718785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1712200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.846582329
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9318522880 18665156 20032147 19638242 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 6.9321047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1812878042
MESH:D008107 Liver Diseases Acetaminophen 6.7219460945 11587558 19014921 16610002 12969438 16611625 19784758 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7217034775
MESH:D008107 Liver Diseases Phenobarbital 6.7219363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.8719389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.8719426721 19073162 21071580 19090486 19255062 21047994 20583210 2422723 18648771 19551842 19294768 2862719 20137499 20434301 19254457 19850985 19690152 20118626 18977376 16942905 19638242 18978307 21278145 20501860 12112319 19833225 19996281 15885732 15175105 19427195 12771043 9163691 19499222 19812893 19642983 20492335 21167192 10737359 20101389 18644402 19256749 18754104 20405173 20452335
MESH:D008113 Liver Neoplasms Phenobarbital 14.8719812893 19482888 19073162 15975961 8742319 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 14.8720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.8716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 19.77598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 19.7718164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.7716267830 18079962 19009564 18164116 19519916 18544905 19539802 17942915 18282651 18775883 18308698 18253720 18093689 16842330 2563599 3124819 17854601 9362446 19126423 17174075 21159647 19004024
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.7717172636 1399818 2563599 18308698 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.7712151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.3020970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3019555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.903581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.903581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.6720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.436482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4416540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4416965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.612563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.612563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311399792 11896295 11222880 11118676
MESH:D019310 Pseudolymphoma Phenobarbital 4.7612752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3018551238
MESH:D012640 Seizures Phenobarbital 6.304039156 11442880 16876388 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.736582329 6587162 1399818 3712494 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.737505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.731399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.218074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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