AutismKB 2.0

Annotation Detail for SLC22A7


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC22A7 ( MGC24091,MGC45202,NLT,OAT2 )
Gene Full Name: solute carrier family 22 (organic anion transporter), member 7
Band: 6p21.1
Quick LinksEntrez ID:10864; OMIM: 604995; Uniprot ID:S22A7_HUMAN; ENSEMBL ID: ENSG00000137204; HGNC ID: 10971
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transmembrane transport of small molecules
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D000082 Acetaminophen Acetaminophen results in decreased activity of SLC22A7 proteindecreases activity 12388633
D000082 Acetaminophen Acetaminophen affects the expression of SLC22A7 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC22A7 proteinaffects expression 20106945
D000493 Allopurinol SLC22A7 protein results in increased transport of Allopurinolincreases transport 15901346
D010130 p-Aminohippuric Acid SLC22A7 protein results in increased uptake of p-Aminohippuric Acidincreases uptake 15901346
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC22A7 mRNAaffects expression 16483693
D000838 Anions Minocycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions]decreases reaction|increases uptake 11855680
D000838 Anions Oxytetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions]decreases reaction|increases uptake 11855680
D000838 Anions SLC22A7 protein results in increased uptake of Anionsincreases uptake 11855680
D000838 Anions Tetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions]decreases reaction|increases uptake 11855680
D001205 Ascorbic Acid SLC22A7 protein results in increased transport of Ascorbic Acidincreases transport 15901346
D001241 Aspirin Aspirin results in decreased activity of SLC22A7 proteindecreases activity 12388633
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC22A7 mRNAdecreases expression 20106945
D002034 Bumetanide Bumetanide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D002034 Bumetanide SLC22A7 protein results in increased transport of Bumetanideincreases transport 15901346
D002701 Chloramphenicol Chloramphenicol inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
C057862 cyanoginosin LR cyanoginosin LR results in decreased expression of SLC22A7 mRNAdecreases expression 17654400
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC22A7 mRNAdecreases expression 20106945
D019314 Dehydroepiandrosterone Sulfate SLC22A7 protein results in increased transport of Dehydroepiandrosterone Sulfateincreases transport 15901346
D004008 Diclofenac Diclofenac inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D004008 Diclofenac Diclofenac results in decreased activity of SLC22A7 proteindecreases activity 12388633
D004041 Dietary Fats Dietary Fats affects the expression of SLC22A7 mRNAaffects expression 17086191
D004041 Dietary Fats resveratrol inhibits the reaction [Dietary Fats affects the expression of SLC22A7 mRNA]affects expression|decreases reaction 17086191
D004917 Erythromycin Erythromycin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D004958 Estradiol Estradiol results in decreased expression of SLC22A7 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of SLC22A7 mRNAincreases expression 11879818
C017296 estrone sulfate Fumarates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate]increases reaction|increases uptake 15901346
C017296 estrone sulfate SLC22A7 protein results in increased uptake of estrone sulfateincreases uptake 15901346
C017296 estrone sulfate Succinates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate]increases reaction|increases uptake 15901346
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SLC22A7 mRNAdecreases expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SLC22A7 mRNAdecreases expression 17108234
D005472 Fluorouracil SLC22A7 protein results in increased transport of Fluorouracilincreases transport 15901346
D005650 Fumarates Fumarates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate]increases reaction|increases uptake 15901346
D005665 Furosemide Furosemide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D005977 Glutarates SLC22A7 protein results in increased transport of Glutaratesincreases transport 15901346
D007052 Ibuprofen Ibuprofen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D007052 Ibuprofen Ibuprofen results in decreased activity of SLC22A7 proteindecreases activity 12388633
D007213 Indomethacin Indomethacin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D007213 Indomethacin Indomethacin results in decreased activity of SLC22A7 proteindecreases activity 12388633
D007660 Ketoprofen Ketoprofen results in decreased activity of SLC22A7 proteindecreases activity 12388633
D008528 Mefenamic Acid Mefenamic Acid results in decreased activity of SLC22A7 proteindecreases activity 12388633
D008727 Methotrexate SLC22A7 protein results in increased uptake of Methotrexateincreases uptake 15901346
C030957 methylmercury II methylmercury II results in decreased expression of SLC22A7 mRNAdecreases expression 17905399
D008911 Minocycline Minocycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions]decreases reaction|increases uptake 11855680
D009288 Naproxen Naproxen results in decreased activity of SLC22A7 proteindecreases activity 12388633
C026209 oltipraz oltipraz results in decreased expression of SLC22A7 mRNAdecreases expression 16837569
D010118 Oxytetracycline Oxytetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions]decreases reaction|increases uptake 11855680
D017239 Paclitaxel SLC22A7 protein results in increased transport of Paclitaxelincreases transport 15901346
C023036 perfluorooctanoic acid SLC22A7 protein affects the transport of perfluorooctanoic acidaffects transport 11879818
D010615 Phenacetin Phenacetin results in decreased activity of SLC22A7 proteindecreases activity 12388633
D010634 Phenobarbital Phenobarbital results in decreased expression of SLC22A7 mRNAdecreases expression 16837569
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SLC22A7 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of SLC22A7 mRNAdecreases expression 19482888
D010894 Piroxicam Piroxicam results in decreased activity of SLC22A7 proteindecreases activity 12388633
D015232 Dinoprostone SLC22A7 protein results in increased transport of Dinoprostoneincreases transport 15901346
D015237 Dinoprost SLC22A7 protein results in increased uptake of Dinoprostincreases uptake 15901346
C059514 resveratrol resveratrol inhibits the reaction [Dietary Fats affects the expression of SLC22A7 mRNA]affects expression|decreases reaction 17086191
D012293 Rifampin Rifampin results in decreased expression of SLC22A7 mRNAdecreases expression 16837569
D020156 Salicylic Acid Salicylic Acid results in decreased activity of SLC22A7 proteindecreases activity 12388633
D020156 Salicylic Acid SLC22A7 protein results in increased uptake of Salicylic Acidincreases uptake 12388633
D013024 Soybean Oil Soybean Oil affects the expression of SLC22A7 mRNAaffects expression 15770074
D013386 Succinates Succinates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate]increases reaction|increases uptake 15901346
D013467 Sulindac Sulindac results in decreased activity of SLC22A7 proteindecreases activity 12388633
D013739 Testosterone Testosterone results in decreased expression of SLC22A7 mRNAdecreases expression 11879818
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC22A7 mRNAdecreases expression 16837569
20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC22A7 mRNAdecreases expression 16054898
D013752 Tetracycline Acetaminophen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D013752 Tetracycline Bumetanide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D013752 Tetracycline Chloramphenicol inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D013752 Tetracycline Diclofenac inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D013752 Tetracycline Erythromycin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D013752 Tetracycline Furosemide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D013752 Tetracycline Ibuprofen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D013752 Tetracycline Indomethacin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]decreases reaction|increases transport 15901346
D013752 Tetracycline SLC22A7 protein results in increased transport of Tetracyclineincreases transport 15901346
D013752 Tetracycline SLC22A7 protein results in increased uptake of Tetracyclineincreases uptake 11855680
D013752 Tetracycline Tetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions]decreases reaction|increases uptake 11855680
D015215 Zidovudine SLC22A7 protein results in increased uptake of Zidovudineincreases uptake 15901346
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 4.9514745880
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 11.2112039119
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.216195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.2111752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.0218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3917505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.309612607
MESH:D058186 Acute Kidney Injury Diclofenac 21.817897758
MESH:D058186 Acute Kidney Injury Ibuprofen 21.816375363
MESH:D058186 Acute Kidney Injury Naproxen 21.817897758
MESH:D058186 Acute Kidney Injury resveratrol 21.8116538975
MESH:D058186 Acute Kidney Injury Sulindac 21.817897758
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 18.2720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 18.2711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 18.2714692618
MESH:D000230 Adenocarcinoma Fluorouracil 18.2717638652
MESH:D000230 Adenocarcinoma Ibuprofen 18.2710697514
MESH:D000230 Adenocarcinoma Indomethacin 18.2716537180
MESH:D000230 Adenocarcinoma Sulindac 18.2711910360
MESH:D000236 Adenoma Benzo(a)pyrene 13.336695378
MESH:D000236 Adenoma Indomethacin 13.3311497255
MESH:D000236 Adenoma resveratrol 13.3315688382
MESH:D000236 Adenoma Sulindac 13.3310223192
MESH:D018248 Adenoma, Liver Cell Phenobarbital 8.3017620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.3016835633
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 8.7517942926
MESH:D011125 Adenomatous Polyposis Coli Sulindac 8.7516460482 11874996 15623613 17611924 11535846 12394442 19003578
MESH:D016301 Alveolar Bone Loss Indomethacin 4.8217225004
MESH:D000544 Alzheimer Disease Ibuprofen 5.9318351690
MESH:D000544 Alzheimer Disease Indomethacin 5.9315579461 17627676
MESH:D000544 Alzheimer Disease resveratrol 5.9316183991 16162502
MESH:D000707 Anaphylaxis Ibuprofen 4.729532969
MESH:D000740 Anemia Fluorouracil 12.2616511603 15504547 17963324
MESH:D000740 Anemia Phenacetin 12.262444515
MESH:D000740 Anemia Tetrachlorodibenzodioxin 12.2611748828
MESH:D000743 Anemia, Hemolytic Phenacetin 4.7717698508 17082564 1949026
MESH:D000799 Angioedema Acetaminophen 3.3010982225
MESH:D000987 Antisocial Personality Disorder Testosterone 5.317506515
MESH:D001014 Aortic Aneurysm Dinoprostone 10.5110231640
MESH:D001014 Aortic Aneurysm Indomethacin 10.5110231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 17.0919183758
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 17.0910388637
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 17.0910388637
MESH:D001161 Arteriosclerosis Dietary Fats 8.1715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.1711256880
MESH:D018771 Arthralgia Indomethacin 4.622160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.2015885639
MESH:D001169 Arthritis, Experimental resveratrol 6.2017115116
MESH:D001172 Arthritis, Rheumatoid Indomethacin 6.8711248219
MESH:D001172 Arthritis, Rheumatoid Methotrexate 6.8717286800
MESH:D001172 Arthritis, Rheumatoid Minocycline 6.8714528503
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.2520485159 12372130
MESH:D050197 Atherosclerosis resveratrol 2.9416873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 2.6718445737
MESH:D001321 Autistic Disorder Dehydroepiandrosterone Sulfate 2.6715820420
MESH:D001477 Bartter Syndrome Dinoprostone 10.9515976003
MESH:D001477 Bartter Syndrome Indomethacin 10.9510684365
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.5712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4015746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.0715867366
MESH:D001913 Bowen's Disease Sulindac 4.8111207687
MESH:D001929 Brain Edema Indomethacin 4.4811481608
MESH:D002545 Brain Ischemia Ibuprofen 14.0815837124
MESH:D002545 Brain Ischemia Indomethacin 14.0812524144
MESH:D002545 Brain Ischemia resveratrol 14.0817600658
MESH:D001932 Brain Neoplasms Aspirin 3.9515481559
MESH:D001943 Breast Neoplasms Ascorbic Acid 11.4916443354
MESH:D001943 Breast Neoplasms Aspirin 11.4915161893
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 11.4917474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 11.4920435547
MESH:D001943 Breast Neoplasms Estradiol 11.4917261762 16675129 17289903 12948864 14630087 19861407 18497071 17018787
MESH:D001943 Breast Neoplasms estrone sulfate 11.4917261762
MESH:D001943 Breast Neoplasms Fluorouracil 11.4916595493 18608205 16557594 15136595 18357371 16110121 19217205
MESH:D001943 Breast Neoplasms Indomethacin 11.4917401462
MESH:D001943 Breast Neoplasms Methotrexate 11.4916978400
MESH:D001943 Breast Neoplasms Paclitaxel 11.4918234424 18323546 11325840 16244791 16115903 15136595 18223236 16273361
MESH:D001943 Breast Neoplasms resveratrol 11.4916393696 17651959 17534123
MESH:D001943 Breast Neoplasms Sulindac 11.4916642371
MESH:D001943 Breast Neoplasms Testosterone 11.4917261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.4920435547
MESH:D002056 Burns Indomethacin 4.1810459503
MESH:D002100 Cachexia Ibuprofen 10.8815141370
MESH:D002100 Cachexia Indomethacin 10.8816537180 15141370 11239499 15625704
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9216111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.1216051944
MESH:D002277 Carcinoma Fluorouracil 6.7617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.7616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.903084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 14.9021507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.9016924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 14.9018930000 17971768 17045692 16332177 16799960 17088986
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 14.9016391822
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 14.9016313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 14.9017173139 1701930 20007298 20935162 6705139
MESH:D006528 Carcinoma, Hepatocellular resveratrol 14.9016227395 19321006
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 9.6411053908
MESH:D018827 Carcinoma, Lewis Lung resveratrol 9.6416675471
MESH:D018276 Carcinoma, Medullary Indomethacin 4.8114736730 11352223 18791128
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.8218695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 5.8217341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.2620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 9.2618986760 16757204 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 9.2612636206 15482327
MESH:D002294 Carcinoma, Squamous Cell resveratrol 9.2616227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0518850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases resveratrol 3.1015458977
MESH:D002386 Cataract Acetaminophen 2.2510977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.0412371664
MESH:D002471 Cell Transformation, Neoplastic Dinoprost 13.0416192471
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 13.0416192471
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.0418566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.734080065
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.4620678186
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D002764 Cholecystitis Indomethacin 4.6211181007
MESH:D002779 Cholestasis Cyclosporine 6.4319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 6.4316919318 11677210 17681005 17110522 16105132 15861022 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8616354765 15340226 12621046 15668235 8697196
MESH:D003092 Colitis resveratrol 3.6116474422
MESH:D003110 Colonic Neoplasms Aspirin 12.3912411196
MESH:D003110 Colonic Neoplasms Fluorouracil 12.3917172411 17725105 17169374 16510598 17016597 15001691 17287894 18772588 16340194 17018589
MESH:D003110 Colonic Neoplasms Indomethacin 12.3915786552 15963497 15625704 11260862 15936596 15637740
MESH:D003110 Colonic Neoplasms Piroxicam 12.3915824018
MESH:D003110 Colonic Neoplasms resveratrol 12.3916338953
MESH:D003110 Colonic Neoplasms Sulindac 12.3912458338 12902858
MESH:D015179 Colorectal Neoplasms Aspirin 7.4717047198
MESH:D015179 Colorectal Neoplasms Fluorouracil 7.4717695437 18448328 16303861 18949393 20501625 17094418 18802399 18288408 18383874 18509181 16524972 16331619 16282729 17255274 17401013 17454858 17594712 16391804 14970324 15148649 15289873 17016601
MESH:D015179 Colorectal Neoplasms Indomethacin 7.4718059344 12606626 11197048 17054584
MESH:D015179 Colorectal Neoplasms Paclitaxel 7.4718802399
MESH:D015179 Colorectal Neoplasms resveratrol 7.4716550006
MESH:D015179 Colorectal Neoplasms Sulindac 7.4710666051 18059344 11076880 11197048
MESH:D003139 Common Cold Ascorbic Acid 4.9317323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6114669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.3916507316
MESH:D018352 Coronavirus Infections Indomethacin 5.1717302372
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.5512039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5515322242 20055451 10048152
MESH:D003550 Cystic Fibrosis Methotrexate 3.7819747007
MESH:D007644 Darier Disease Fluorouracil 4.2516733453
MESH:D003882 Dermatomyositis Methotrexate 4.6120191521
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.3316873680
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 4.0116506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0117107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.5119279558
MESH:D003928 Diabetic Nephropathies resveratrol 7.5116286809
MESH:D003930 Diabetic Retinopathy Sulindac 4.6712861449 17621415
MESH:D003967 Diarrhea Dinoprostone 6.9110446763 11488427 7237001
MESH:D003967 Diarrhea Indomethacin 6.917237001 7907874
MESH:D004283 Dog Diseases Allopurinol 5.7210449224
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 7.4616177239 16485898 16109766 11743745 19739265 10915739 11287661 11529661 16081117 10774834 14986274 18071297 15619225 18713872 12392966 12540782 11421492 10663392 11834606 14550746 19420014 12705907 2444490 11739529 17522070 12153990 17562736 17906064 19923254 11461765 19370779 19164858 16393943 19416960 14725611 16781746 12594235 16227642 15968718 19085960 12958197
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 7.4617654400
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 7.4620420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 7.4617522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.8811462148
MESH:D004362 Drug Toxicity Zidovudine 6.8815040536
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 11.4418446180 16133044 18450898
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 11.4418446180 16326151 18043480 17190690 16133044 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 3.6317329845 17045617 17351913 10671773 11595415 11991626 11535926 17202747 17151854 11595431 16699067
MESH:D050171 Dyslipidemias Dietary Fats 3.0618367378
MESH:D004417 Dyspnea Furosemide 4.4016935035
MESH:D004421 Dystonia Phenobarbital 3.511851702
MESH:C538011 Eales disease Ascorbic Acid 4.939068938
MESH:D004487 Edema Aspirin 34.6717259670
MESH:D004487 Edema Diclofenac 34.6716273134
MESH:D004487 Edema Furosemide 34.6711834646
MESH:D004487 Edema Indomethacin 34.677907874 8273558 16100529 7990266 19703484 8985016 10653021
MESH:D004487 Edema Ketoprofen 34.677990266
MESH:D004487 Edema perfluorooctanoic acid 34.6717259670 12083418
MESH:D004487 Edema Piroxicam 34.677907874
MESH:D004487 Edema resveratrol 34.678985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 34.6712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3515322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.6812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Minocycline 12.6811835378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 12.6817872969
MESH:D016889 Endometrial Neoplasms Estradiol 2.6219148513 18566989 11473722
MESH:D004715 Endometriosis Ibuprofen 23.7015652904
MESH:D004715 Endometriosis Indomethacin 23.7015652904
MESH:D004715 Endometriosis Naproxen 23.7015652904
MESH:D004715 Endometriosis Sulindac 23.7015652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 23.709294722 10568697
MESH:D019446 Endotoxemia Ibuprofen 9.0811545620
MESH:D019446 Endotoxemia Indomethacin 9.0818509659
MESH:D004751 Enteritis Indomethacin 4.2010567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 10.6317980183
MESH:D020345 Enterocolitis, Necrotizing resveratrol 10.6317923197
MESH:D004802 Eosinophilia Indomethacin 3.5411298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.583659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.333922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.5920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.096401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.737750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.483659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 15.2416530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 15.2417638652 16785472 16337965 16481741 15173087
MESH:D004938 Esophageal Neoplasms Indomethacin 15.2411005569
MESH:D004938 Esophageal Neoplasms Paclitaxel 15.2416481741
MESH:D004938 Esophageal Neoplasms Piroxicam 15.2415878914
MESH:D004938 Esophageal Neoplasms Sulindac 15.2412235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6011564622
MESH:D005234 Fatty Liver Cyclosporine 19.5919224547
MESH:D005234 Fatty Liver Dietary Fats 19.5918296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.5915345470
MESH:D005234 Fatty Liver Tetracycline 19.5919224547 16917069
MESH:D005234 Fatty Liver Zidovudine 19.5918299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9311858732
MESH:D005334 Fever Dinoprost 17.9911852909
MESH:D005334 Fever Dinoprostone 17.9916997862 11852909
MESH:D005334 Fever Ibuprofen 17.9916997862
MESH:D005334 Fever Indomethacin 17.9910431976 17627676 11852909
MESH:D018221 Fibromatosis, Abdominal Sulindac 4.9414745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 4.5919069698
MESH:D005354 Fibrosarcoma Indomethacin 4.3610962813
MESH:D005355 Fibrosis Cyclosporine 16.8712639820 12168785
MESH:D005355 Fibrosis Dietary Fats 16.8718296743
MESH:D005355 Fibrosis Indomethacin 16.8717994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.8720067830
MESH:D005391 Firesetting Behavior Testosterone 5.317506515
MESH:D005499 Folliculitis Indomethacin 4.6211298111
MESH:D005600 Fragile X Syndrome Minocycline 6.2118835858
MESH:D005756 Gastritis Acetaminophen 9.3316983495
MESH:D005756 Gastritis Indomethacin 9.3315046732
MESH:D005764 Gastroesophageal Reflux Sulindac 4.5011910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.688708960
MESH:D005909 Glioblastoma Aspirin 10.0812870263
MESH:D005909 Glioblastoma Indomethacin 10.0812870263
MESH:D005909 Glioblastoma Testosterone 10.0817162496
MESH:D005910 Glioma Fluorouracil 5.4416145905
MESH:D005910 Glioma Indomethacin 5.4418371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8511849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0510696789
MESH:D006073 Gout Indomethacin 4.8111248219
MESH:D006086 Graft vs Host Disease Methotrexate 4.6216518429
MESH:D006261 Headache Aspirin 4.4115240983
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.7515162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Indomethacin 6.7515482327
MESH:D034381 Hearing Loss Furosemide 4.3717868369
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 9.4216080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.4220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.4210048152 11294989
MESH:D006333 Heart Failure Furosemide 3.7216011733 12660669 16845234
MESH:D006402 Hematologic Diseases Zidovudine 4.2212579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8511000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.0915633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.1715135802
MESH:D006521 Hepatitis, Chronic Diclofenac 10.5814986274
MESH:D006521 Hepatitis, Chronic Minocycline 10.5814986274
MESH:D006529 Hepatomegaly perfluorooctanoic acid 11.513609246
MESH:D006529 Hepatomegaly Phenobarbital 11.5116109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.5112621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.2616490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.4815709030
MESH:D006561 Herpes Simplex resveratrol 3.6516876885
MESH:D006628 Hirsutism Testosterone 5.1017019078
MESH:D015658 HIV Infections Zidovudine 3.1911698656 17358032 20032539 11141242 11363243
MESH:D019584 Hot Flashes Estradiol 3.2117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.508697196 18606429 16354765 16959395 15340226
MESH:D012001 Hyperacusis Aspirin 5.2115240983
MESH:D006930 Hyperalgesia Acetaminophen 15.2416870215
MESH:D006930 Hyperalgesia Dinoprostone 15.2416793879
MESH:D006930 Hyperalgesia Indomethacin 15.2412727271
MESH:D006930 Hyperalgesia perfluorooctanoic acid 15.2412083418
MESH:D034321 Hyperamylasemia Indomethacin 5.1717883296
MESH:D017588 Hyperandrogenism Dehydroepiandrosterone Sulfate 10.8017392600
MESH:D017588 Hyperandrogenism Testosterone 10.8017019078
MESH:D006934 Hypercalcemia Furosemide 4.5917652376
MESH:D053565 Hypercalciuria Furosemide 5.1117652376
MESH:D006937 Hypercholesterolemia Dietary Fats 7.6221332399
MESH:D006937 Hypercholesterolemia resveratrol 7.6217188708
MESH:D006940 Hyperemia Indomethacin 4.4712524144
MESH:D006949 Hyperlipidemias Dietary Fats 12.6521332399
MESH:D006949 Hyperlipidemias Indomethacin 12.6517546600
MESH:D006949 Hyperlipidemias resveratrol 12.6516873680
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.3315086907
MESH:D006973 Hypertension Cyclosporine 4.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.1718850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 4.7616612254
MESH:D006984 Hypertrophy Ibuprofen 4.4916672835
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8317488730
MESH:D007006 Hypogonadism Testosterone 4.2012002444
MESH:C537153 Hypomagnesemia primary Furosemide 5.1111041285
MESH:D007018 Hypopituitarism Testosterone 5.6517426086
MESH:D007019 Hypoproteinemia Furosemide 5.3316096441
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2816569931 16945680
MESH:D007022 Hypotension Chloramphenicol 8.7210100024
MESH:D007022 Hypotension Furosemide 8.7211041285
MESH:D007024 Hypotension, Orthostatic Furosemide 4.8715811171
MESH:D007077 Ileal Diseases Indomethacin 4.4810574470 18306037
MESH:D007079 Ileitis Indomethacin 4.8110647630 10651667 16133968
MESH:D007174 Impulse Control Disorders Testosterone 5.317506515
MESH:D007235 Infant, Premature, Diseases Ibuprofen 12.3716133044
MESH:D007235 Infant, Premature, Diseases Indomethacin 12.3716133044
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.1217600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.1217937319
MESH:D007249 Inflammation Diclofenac 31.1416273134
MESH:D007249 Inflammation Dietary Fats 31.1420412841
MESH:D007249 Inflammation Erythromycin 31.1419502290
MESH:D007249 Inflammation Ibuprofen 31.143291741
MESH:D007249 Inflammation Indomethacin 31.1412568917 3291741 7812673
MESH:D007249 Inflammation Naproxen 31.143291741
MESH:D007249 Inflammation perfluorooctanoic acid 31.1412083418
MESH:D007249 Inflammation resveratrol 31.1416366677
MESH:D007249 Inflammation Sulindac 31.143291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 31.1412200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.0016624496
MESH:D007333 Insulin Resistance Dietary Fats 6.1511836018 18457598
MESH:D007333 Insulin Resistance Estradiol 6.1516627594 16393666
MESH:D007410 Intestinal Diseases Indomethacin 3.8011855677 17994277 15831440 10210152 17329856 15610444 11686837 18236018 11713966
MESH:D007414 Intestinal Neoplasms Piroxicam 9.0810213222
MESH:D007414 Intestinal Neoplasms Sulindac 9.0812628509 10213222 12663524 10223192 12584176 12351151
MESH:D007417 Intestinal Polyps Sulindac 4.4912394442 11245490
MESH:D019586 Intracranial Hypertension Indomethacin 4.8215241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8516580747
MESH:D007579 Jejunal Diseases Indomethacin 4.4810574470 18306037 16133968
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8915604871
MESH:D007674 Kidney Diseases Acetaminophen 15.5712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 15.5718776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 15.5715618244
MESH:D007674 Kidney Diseases Furosemide 15.5711041285
MESH:D007674 Kidney Diseases Indomethacin 15.5717190690
MESH:D007680 Kidney Neoplasms Cyclosporine 14.2012371664
MESH:D007680 Kidney Neoplasms Estradiol 14.2015610895
MESH:D007680 Kidney Neoplasms Fluorouracil 14.2016985049
MESH:D007680 Kidney Neoplasms Zidovudine 14.2012579204
MESH:D007805 Language Development Disorders Methotrexate 4.609562676
MESH:D016773 Leishmaniasis, Cutaneous Allopurinol 7.7112207774 9314461
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 7.7110320625 12228301 11703811
MESH:D007898 Leishmaniasis, Visceral Allopurinol 4.7010449224 7498017 11332679
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 3.9320370541
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.5215631656 10785260 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.5318360721
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.2116087638
MESH:D007964 Leukocytosis Indomethacin 4.8216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.1717980183
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.698812269
MESH:D008080 Liposarcoma Paclitaxel 4.3217353645
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.1711479899
MESH:D008103 Liver Cirrhosis Dietary Fats 9.3018296743
MESH:D008103 Liver Cirrhosis Methotrexate 9.3014986274
MESH:D008103 Liver Cirrhosis Phenobarbital 9.3021047994
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 3.8712468960
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 5.8615816358
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.8614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 5.8618194892
MESH:D008106 Liver Cirrhosis, Experimental oltipraz 5.8616544323
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.8612878042
MESH:D008107 Liver Diseases Acetaminophen 16.7416610002 12969438 11587558 19460945 19784758 19014921 12587719 16611625
MESH:D008107 Liver Diseases Diclofenac 16.7416867024 14566034
MESH:D008107 Liver Diseases Dinoprostone 16.7415816358
MESH:D008107 Liver Diseases Naproxen 16.7416867024
MESH:D008107 Liver Diseases Phenobarbital 16.7419363144
MESH:D008107 Liver Diseases Piroxicam 16.7416867024
MESH:D008107 Liver Diseases Sulindac 16.7414986274 16867024
MESH:D017114 Liver Failure, Acute Acetaminophen 2.7716871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.2818177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.2820195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 18.2816603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 18.2814757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 18.2819073162 15975961 19812893 8742319 19482888 21047994
MESH:D008113 Liver Neoplasms resveratrol 18.2820405173 19073162 19321006 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.2816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 11.268603461
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 11.2618544905
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 11.266150874 18308698 1399818 2563599 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.2612151625
MESH:D008171 Lung Diseases Ascorbic Acid 3.5816863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.4718516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 13.6214755239
MESH:D008175 Lung Neoplasms Ascorbic Acid 13.6216401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 13.6217053015 20135361 18816296 20064080 20464547 18569708 18520028 20869020 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 13.6215246190
MESH:D008175 Lung Neoplasms Indomethacin 13.6216537180 11497255 11053908
MESH:D008175 Lung Neoplasms Piroxicam 13.6211195469 15824018
MESH:D008175 Lung Neoplasms Sulindac 13.6219359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 13.6211884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 13.6218800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 11.5015086387
MESH:D008178 Lupus Erythematosus, Cutaneous Rifampin 11.5011422169
MESH:D008180 Lupus Erythematosus, Systemic Rifampin 3.8011422169
MESH:D008223 Lymphoma Methotrexate 3.5617352296
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8017088997
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 7.5214749477
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 7.5214749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.7115688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.0711408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 8.0710697514
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 8.078985016 11606380
MESH:D020149 Manganese Poisoning Estradiol 3.9319453300
MESH:D008545 Melanoma Paclitaxel 4.6512040289 16342250 12025231
MESH:D008545 Melanoma resveratrol 4.6517992120
MESH:D008545 Melanoma Sulindac 4.6516642371
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0419513568
MESH:D008659 Metabolic Diseases resveratrol 3.8917112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2416801185
MESH:D008708 Methemoglobinemia Phenacetin 4.4616296465 4834387 3537620 1949026
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.2917358032
MESH:D008881 Migraine Disorders Aspirin 10.6615240983
MESH:D008881 Migraine Disorders Indomethacin 10.6611903285
MESH:D008881 Migraine Disorders Naproxen 10.6618803445
MESH:D020326 Migraine without Aura Dinoprostone 4.7511304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 12.0016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 12.0016757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 12.0012636206
MESH:D052016 Mucositis Methotrexate 4.7417488658
MESH:D009101 Multiple Myeloma Paclitaxel 6.3314749477
MESH:D009101 Multiple Myeloma resveratrol 6.3317935668 17164350 16267019 17049120 14749477 16490592
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Minocycline 6.2211835378
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.3317962980
MESH:D009164 Mycobacterium Infections Rifampin 5.0018474467
MESH:D009203 Myocardial Infarction Aspirin 5.4212692751
MESH:D009203 Myocardial Infarction resveratrol 5.4217188708 16525036 17125593 17015251 16317513 16456233
MESH:D017202 Myocardial Ischemia resveratrol 7.5817015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.5812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.8616810080
MESH:D009205 Myocarditis resveratrol 4.2217322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9417484760
MESH:D009325 Nausea Aspirin 4.6715240983
MESH:D009362 Neoplasm Metastasis Indomethacin 5.4011053908 11239499 16537180
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.4015867366
MESH:D009369 Neoplasms Benzo(a)pyrene 6.8511141357
MESH:D009369 Neoplasms Fluorouracil 6.8518239605 16928823 18600527
MESH:D009369 Neoplasms Piroxicam 6.8516684565
MESH:D009374 Neoplasms, Experimental Indomethacin 7.6715625704 10663608
MESH:D009374 Neoplasms, Experimental resveratrol 7.678985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2017289903
MESH:D009395 Nephritis, Interstitial Ibuprofen 14.896375363
MESH:D009395 Nephritis, Interstitial Minocycline 14.89444868 435818
MESH:D009395 Nephritis, Interstitial Tetracycline 14.899884423
MESH:D009397 Nephrocalcinosis Furosemide 5.3315086907
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8319348381 18481113
MESH:D009410 Nerve Degeneration Ibuprofen 3.9710961664
MESH:D009421 Nervous System Malformations Estradiol 7.7711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.7714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 16.5318514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 16.5312349958
MESH:D019636 Neurodegenerative Diseases resveratrol 16.5317652729
MESH:D019636 Neurodegenerative Diseases Sulindac 16.5316850258 17266991
MESH:D020078 Neurogenic Inflammation resveratrol 3.9017929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0616436463
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.439802331
MESH:D053206 Nocturnal Enuresis Furosemide 5.3317945291
MESH:D009765 Obesity Ascorbic Acid 4.3717217161
MESH:D009765 Obesity Dietary Fats 4.3711836018 19632207 17217161 21332399 20518802 18457598 20132043 16723640 18674790
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.626374098
MESH:D010003 Osteoarthritis Aspirin 15.177009135
MESH:D010003 Osteoarthritis Diclofenac 15.1718287210
MESH:D010003 Osteoarthritis Ibuprofen 15.177009135
MESH:D010003 Osteoarthritis Indomethacin 15.177009135
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 5.9318500342
MESH:D010014 Osteolysis Paclitaxel 4.4415867366
MESH:D010018 Osteomalacia Phenobarbital 3.8317016548
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.7617513867
MESH:D010051 Ovarian Neoplasms Estradiol 4.3819401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 4.3811161223
MESH:D010146 Pain Acetaminophen 25.2516870215
MESH:D010146 Pain Aspirin 25.256995502 6363464
MESH:D010146 Pain Diclofenac 25.2513679232
MESH:D010146 Pain Ibuprofen 25.253291741
MESH:D010146 Pain Indomethacin 25.2517627676 17440234 3291741 13679232
MESH:D010146 Pain Naproxen 25.253291741
MESH:D010146 Pain Sulindac 25.253291741
MESH:D010149 Pain, Postoperative Ibuprofen 9.6616678543
MESH:D010149 Pain, Postoperative Indomethacin 9.6618702446 12538197
MESH:D010190 Pancreatic Neoplasms Fluorouracil 10.5716929163 19003803 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Ibuprofen 10.5712384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 10.5716965848
MESH:D010190 Pancreatic Neoplasms Sulindac 10.5716820089 11504793
MESH:D010195 Pancreatitis Indomethacin 3.4315028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1911578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.1716537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.6512349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.1711903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7012520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.8811026799
MESH:D010437 Peptic Ulcer Indomethacin 4.6111148446
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.0011156591
MESH:D010518 Periodontitis Indomethacin 4.3717225004
MESH:D020795 Photophobia Aspirin 5.2115240983
MESH:D011141 Polyuria Furosemide 5.1117945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0518163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.4612371664
MESH:D011230 Precancerous Conditions Phenobarbital 7.462563599
MESH:D047928 Premature Birth Indomethacin 4.6017000239
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 13.2517132714
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 13.2516679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.2511399792 11118676 11222880 11896295
MESH:D017096 Prion Diseases Tetracycline 4.8710903871
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.2620887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 9.2620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8819082440 18626508
MESH:D011471 Prostatic Neoplasms Ibuprofen 1.8817409433
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.8816729912 17172428 17136230 16356831
MESH:D011471 Prostatic Neoplasms resveratrol 1.8817636462 17675339 17804756 15767336 17718901 16731767
MESH:D011507 Proteinuria Ibuprofen 8.076375363
MESH:D011507 Proteinuria Indomethacin 8.0711849393
MESH:D011537 Pruritus Ethinyl Estradiol 2.7815861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 3.9512752131
MESH:D011565 Psoriasis Cyclosporine 5.1816882103
MESH:D011565 Psoriasis Methotrexate 5.1817410198
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.7814606601
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5618722050 18286688 16160472 15538739
MESH:D051437 Renal Insufficiency Methotrexate 4.1917352296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0316325855
MESH:D015427 Reperfusion Injury Furosemide 6.1716526316
MESH:D015427 Reperfusion Injury resveratrol 6.1717058453 16314181 17520802 15827377 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.1312394941 15912074 16096441
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3318990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.1416849425
MESH:D012220 Rhinitis Aspirin 3.9112372130
MESH:D012640 Seizures Phenobarbital 2.3411442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.286407741
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.6516631401
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 4.7412269725
MESH:D012871 Skin Diseases Ascorbic Acid 3.0518709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 7.8110029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 7.818985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.8116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.3916709447
MESH:D013272 Stomach Diseases Indomethacin 3.8810486359 15472012 16184426 16113693 10192188 17160473 10215738 17207306 18545984 15038085 18209964 16280098 17638125
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 7.3520155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 7.3516951190 19084572 18396642 19015929 17172411 17498489 18567086 15786421 16424979 17522103
MESH:D013274 Stomach Neoplasms Furosemide 7.3517052386
MESH:D013274 Stomach Neoplasms Indomethacin 7.3515609394
MESH:D013274 Stomach Neoplasms Paclitaxel 7.3518506536 18396642
MESH:D013274 Stomach Neoplasms Zidovudine 7.3517696246
MESH:D013276 Stomach Ulcer Ascorbic Acid 9.6918726076
MESH:D013276 Stomach Ulcer Indomethacin 9.6917895592 12500499 17977527 11145282 15138204 15104355 10423059 11595415 17918041 18431645 16934674 14567935 16397915 11523592 16169175 18543354 16755016 12467913 12077510 18237397 11595431 10750652 10878458 17654042 16631530 18726076 11906479 18181030 1323529 17657623 17627676 16150113 12787963 11729361 18209962 18087811 15255614 17135157 18299717 18193104 16252198 12498302
MESH:D013276 Stomach Ulcer Piroxicam 9.6915309881
MESH:D020521 Stroke Ascorbic Acid 7.7716517955 16403987
MESH:D020521 Stroke Aspirin 7.7716403987
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0116321402
MESH:D013436 Sulfhemoglobinemia Phenacetin 6.01978859
MESH:D013576 Syndactyly Methotrexate 4.529562676
MESH:D024801 Tauopathies Paclitaxel 4.2816930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1211994571
MESH:D013927 Thrombosis Aspirin 7.6917672075
MESH:D013927 Thrombosis Ethinyl Estradiol 7.6915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3512697716
MESH:D013964 Thyroid Neoplasms Indomethacin 6.0314736730 11352223 18791128
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.031399818
MESH:D013978 Tibial Fractures Estradiol 4.1419048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.4316280240
MESH:D014062 Tongue Neoplasms resveratrol 8.4316227395
MESH:D014376 Tuberculosis Rifampin 4.4215236969 18397238
MESH:D014456 Ulcer Indomethacin 4.3610574470 17380554
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.7417053015
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 4.7411144890
MESH:D014581 Urticaria Acetaminophen 12.1510982225
MESH:D014581 Urticaria Aspirin 12.1520485159 10982225
MESH:D014581 Urticaria Piroxicam 12.1510982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.0516803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.0517473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 13.2014692618
MESH:D014594 Uterine Neoplasms resveratrol 13.2017044934
MESH:D014594 Uterine Neoplasms Sulindac 13.2018645019
MESH:D014605 Uveitis Cyclosporine 3.441336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.2312579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0512125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.6519057314
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0615869587 14671159
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.7817488730
MESH:D014839 Vomiting Indomethacin 4.2011897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7015886252
MESH:D015430 Weight Gain Dietary Fats 3.2816723640
MESH:D014985 Xerophthalmia Cyclosporine 3.8917120751
Pathway ID Pathway Name
KEGG:04976 Bile secretion
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35848
    • Releated gene ID Related gene Name
    PA35848SLC22A7
    No data
    Releated drug ID Related drug Name
    PA128406956fluorouracil
    PA451954zidovudine
    Drug Bank Top
    No data
    No data
    Drugbank ID Action Drug Name Description
    DB00175 inhibitor Pravastatin Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00199 inhibitor T-Stat Pad-Lot Anti-Bacterial Agents;Macrolides
    DB00277 inhibitor Theophylline rougier elixir Vasodilator Agents;Phosphodiesterase Inhibitors;Bronchodilator Agents;Respiratory Smooth Muscle Relaxants
    DB00313 substrate Valproic Acid Anticonvulsants;Enzyme Inhibitors;Antimanic Agents;GABA Agents
    DB00328 substrate Indomethacin Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Tocolytic Agents;Cardiovascular Agents;Nonsteroidal Anti-inflammatory Agents (NSAIAs);Gout Suppressants
    DB00345 substrate Aminohippurate Diagnostic aids;Indicators and Reagents
    DB00437 substrate Allopurinol Free Radical Scavengers;Antimetabolites;Enzyme Inhibitors;Enzyme Inhibitors Antimetabolites;Gout Suppressants
    DB00456 inhibitor Cefalotin Anti-Bacterial Agents;Cephalosporins
    DB00493 inhibitor Cefotaxime Anti-Bacterial Agents;Cephalosporins
    DB00501 inhibitor Cimetidine Anti-Ulcer Agents;Analgesics;Enzyme Inhibitors;Adjuvants;Histamine Antagonists;Histamine H2 Antagonists
    DB00563 substrate Methotrexate Antineoplastic Agents;Antirheumatic Agents;Antimetabolites;Enzyme Inhibitors;Folic Acid Antagonists;Dermatologic Agents;Immunosuppressive Agents;Nucleic Acid Synthesis Inhibitors;Abortifacient Agents, Nonsteroidal;Abortifacient Agents;Antimetabolites, Antineoplastic
    DB00584 inhibitor Vaseretic Antihypertensive Agents;Angiotensin-converting Enzyme Inhibitors
    DB00595 inhibitor Oxytetracycline Anti-Bacterial Agents;Tetracyclines
    DB00624 inducer Uni-Bol Androgens
    DB00759 inhibitor P Onytricin P Anti-Bacterial Agents;Antiprotozoals;Tetracyclines;Protein Synthesis Inhibitors
    DB00887 inhibitor Bumetanide Diuretics;Diuretics, Sulfamyl;Sodium Potassium Chloride Symporter Inhibitors
    DB00917 inhibitor Dinoprostone Oxytocics;Prostaglandins
    DB00936 substrate Mobilat Anti-Infective Agents;Keratolytic Agents;Antifungal Agents
    DB00943 substrate Zalcitabine Anti-HIV Agents;Antimetabolites;Nucleoside and Nucleotide Reverse Transcriptase Inhibitors;Reverse Transcriptase Inhibitors
    DB00945 substrate Extra Strength Aspirin Backache Anticoagulants;Cyclooxygenase Inhibitors;Platelet Aggregation Inhibitors;Fibrinolytic Agents;Salicylates
    DB01004 inhibitor Ganciclovir Antiviral Agents
    DB01009 inhibitor Ketoprofen Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB01016 inhibitor Glucovance Hypoglycemic Agents;Antiarrhythmic Agents;Sulfonylureas
    DB01017 inhibitor Minocycline Anti-Bacterial Agents;Tetracyclines
    DB01032 inhibitor Probenecid Uricosuric Agents;Adjuvants, Pharmaceutic
    DB01045 inhibitor Rifater Enzyme Inhibitors;Antituberculosis Agents;Nucleic Acid Synthesis Inhibitors;Leprostatic Agents;Antibiotics;Antibiotics, Antitubercular
    DB01211 inhibitor Clarithromycin Anti-Bacterial Agents;Other Macrolides;Protein Synthesis Inhibitors;Macrolides
    DB01303 inhibitor Oxtriphylline Bronchodilator Agents
    DB01326 inhibitor Cefamandole Anti-Bacterial Agents;Cephalosporins
    DB01329 inhibitor Cefoperazone Anti-Bacterial Agents;Antibacterial Agents;Cephalosporins
    DB01597 inhibitor Primaxin IV 500 Protease Inhibitors
    DB02527 substrate Cyclic Adenosine Monophosphate
    DB02659 inhibitor Cholic Acid
    DB03553 substrate Glutaric Acid
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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