AutismKB 2.0

Annotation Detail for ARID5A


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Basic Information Top
Gene Symbol:ARID5A ( MRF-1,MRF1,RP11-363D14 )
Gene Full Name: AT rich interactive domain 5A (MRF1-like)
Band: 2q11.2
Quick LinksEntrez ID:10865; OMIM: 611583; Uniprot ID:ARI5A_HUMAN; ENSEMBL ID: ENSG00000196843; HGNC ID: 17361
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016601 4-hydroxytamoxifen ARID5A protein inhibits the reaction [4-hydroxytamoxifen results in increased activity of ESR1 protein]decreases reaction|increases activity 15941852
D000082 Acetaminophen Acetaminophen affects the expression of ARID5A mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of ARID5A mRNAincreases expression 19774075
D004958 Estradiol ARID5A protein inhibits the reaction [Estradiol results in increased activity of ESR1 protein]decreases reaction|increases activity 15941852
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ARID5A mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of ARID5A mRNAincreases expression 19482888
D020849 Raloxifene ARID5A protein inhibits the reaction [Raloxifene results in increased activity of ESR1 protein]decreases reaction|increases activity 15941852
D018038 Sodium Selenite Sodium Selenite results in increased expression of ARID5A mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.836195326
MESH:D000230 Adenocarcinoma Estradiol 2.1511473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.3717620307
MESH:D000419 Albuminuria Raloxifene 4.9217451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0718218290 20041841 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 4.1118651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.1819483382
MESH:D001930 Brain Injuries Raloxifene 4.8316580743
MESH:D001943 Breast Neoplasms Estradiol 2.2617289903 18497071 17261762 16675129 14630087 19861407 12948864 17018787
MESH:D001943 Breast Neoplasms Raloxifene 2.2616912660 17049068 16837676 17595753 17261762 17440819 17893378 15775269 15758505 17242785 17952589 15572757
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7316924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7320935162 1701930 6705139 20007298 17173139
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.3417572228
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9715710769 19225199
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6315775269
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4818974383
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1115894690
MESH:D003072 Cognition Disorders Raloxifene 4.9815800139
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4117474826
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0316285004
MESH:D003928 Diabetic Nephropathies Estradiol 9.8519279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.8515920148 17451421 17308373
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6817562736 12705907 12594235 10663392 12392966 12540782 19164858 17906064 11739529 12153990 16177239 10915739 15968718 11287661 18713872 11529661 16393943 14550746 16485898 11421492 10774834 11461765 11743745 18071297 19370779 19416960 16081117 11834606 19420014 16227642 19923254 14986274 2444490 19739265 16109766 14725611 19085960 16781746 15619225 12958197 17522070
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.6815265979 18218290
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.6815131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004487 Edema Raloxifene 3.6115860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.3215845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 8.3619148513
MESH:D016889 Endometrial Neoplasms Estradiol 8.3611473722 19148513 18566989
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D005234 Fatty Liver Amiodarone 9.0714986274
MESH:D005234 Fatty Liver Raloxifene 9.0717473493
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006331 Heart Diseases Raloxifene 3.7211110106
MESH:D006529 Hepatomegaly Amiodarone 9.9815265979
MESH:D006529 Hepatomegaly Phenobarbital 9.9816109766
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.158137927 9751232
MESH:D006973 Hypertension Raloxifene 2.9517577099 15787275
MESH:D007037 Hypothyroidism Amiodarone 4.8717991464 18020914
MESH:D007333 Insulin Resistance Estradiol 8.0016393666 16627594
MESH:D007333 Insulin Resistance Sodium Selenite 8.0014714311
MESH:D007674 Kidney Diseases Acetaminophen 6.3715629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.3715618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2115610895
MESH:D007889 Leiomyoma Raloxifene 4.8016973256
MESH:D008064 Lipidoses Amiodarone 3.7017567588 15342952
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814716833 14659978
MESH:D008107 Liver Diseases Acetaminophen 4.1312587719 16610002 19784758 16611625 11587558 12969438 19460945 19014921
MESH:D008107 Liver Diseases Phenobarbital 4.1319363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Phenobarbital 2.398742319 19812893 19482888 19073162 21047994 15975961
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.861399818 2563599 17172636 18308698 6150874
MESH:D008133 Long QT Syndrome Amiodarone 3.7915350150 17391786 11989578
MESH:D008171 Lung Diseases Amiodarone 3.5512587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.9218516814
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3614737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7211408345 16891317 17203775 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0015863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6316497877
MESH:D009181 Mycoses Amiodarone 5.3417974566 12754197
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009232 Myxoma Raloxifene 6.0016343187
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 3.9811399458 16427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010024 Osteoporosis Raloxifene 3.5515775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5317823083 17893378 15579764 15758505
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5716740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5716536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5718760546
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9412832656 11597910 12490602
MESH:D011693 Purpura Raloxifene 6.0015770314
MESH:D012640 Seizures Phenobarbital 2.874039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4818724381
MESH:D013276 Stomach Ulcer Amiodarone 3.5918087811
MESH:D020521 Stroke Raloxifene 4.0416837676
MESH:D013610 Tachycardia Amiodarone 4.6211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5219225199
MESH:D013959 Thyroid Diseases Amiodarone 5.2019731979
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D013971 Thyrotoxicosis Amiodarone 5.2219584973 18020914
MESH:D013978 Tibial Fractures Estradiol 15.2419048282
MESH:D013978 Tibial Fractures Raloxifene 15.2419048282
MESH:D016171 Torsades de Pointes Amiodarone 4.5911989578 17467628
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.9017572228
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D054556 Venous Thromboembolism Raloxifene 5.6516837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0016343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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