AutismKB 2.0

Annotation Detail for ME3


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Basic Information Top
Gene Symbol:ME3 ( FLJ34862 )
Gene Full Name: malic enzyme 3, NADP(+)-dependent, mitochondrial
Band: 11q14.2
Quick LinksEntrez ID:10873; OMIM: 604626; Uniprot ID:MAON_HUMAN; ENSEMBL ID: ENSG00000151376; HGNC ID: 6985
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
GLUCONEO-PWYgluconeogenesis I
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00620Pyruvate metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ME3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ME3 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of ME3 mRNAdecreases expression 17202762
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ME3 mRNAdecreases expression 20064835
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ME3 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ME3 mRNAaffects cotreatment|affects expression 17602206
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ME3 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of ME3 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ME3 mRNAaffects cotreatment|increases expression 17942748
C011890 kojic acid kojic acid results in decreased expression of ME3 mRNAdecreases expression 16595896
D008345 Manganese Manganese results in increased expression of ME3 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of ME3 mRNAincreases expression 17175027
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ME3 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ME3 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ME3 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.1911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1914692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.896695378
MESH:D000236 Adenoma Diethylnitrosamine 6.896695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.7117162532 16434500 18056438 19061943 17620307 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000756 Anemia, Sideroblastic Manganese 11.5016910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.5016910769
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9320146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9317474063
MESH:D001943 Breast Neoplasms Estradiol 1.9312948864 19861407 14630087 18497071 17289903 17018787 16675129 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.713084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7118056438 19052882 20432363 17761372 18494052 19171122 20524982 16830150 19335982 19539802 19383236 18978308 19107877 17978847 19394651 20514400 3581430 19701751 19418558 16935385 19519916 17055752 20101231 16878318 10737359 3084413 17162532 18210153 18665156 16569478 18785209 19208518 18971187 16288022 20935162 18506893 17428255 20727157 19822196 16540662 16807293 16502159 20084675 16328049 18393292 19919837 11831363 17138121 16779866 18788625 20007298 10672840 18691550 17173139 16681979 16698587 21159647 20214788 20512989
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7116924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.746135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.747505956 17174075 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.7418566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9817333356 17681005 17110522 16105132 16919318 11677210 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.158697196 15668235 15340226 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2619420014 16081117 10774834 11461765 19164858 12958197 11739529 16485898 11287661 19739265 10915739 12705907 19923254 19416960 18713872 15968718 17906064 17522070 14550746 11421492 12540782 14725611 11529661 16781746 11743745 11834606 10663392 16177239 12153990 16227642 16393943 14986274 15619225 19370779 12392966 16109766 12594235 19085960 2444490 17562736 18071297
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.2619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.0711473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Diethylnitrosamine 8.1720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1715345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005909 Glioblastoma Manganese 4.0017043766
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 15340226 16959395 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Diethylnitrosamine 5.1218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1212200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.0516393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 6.1412587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.1415618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms Estradiol 7.7615610895
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8918665156 18407596 18522880 19638242 20032147
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3012878042
MESH:D008107 Liver Diseases Acetaminophen 4.0119460945 19784758 19014921 16610002 12969438 12587719 16611625 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.767678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.7621137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 14.7617602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.7621167192 20492335 19294768 19256749 19690152 2862719 20137499 20452335 19638242 19812893 19255062 19427195 20101389 20118626 15175105 19551842 19996281 16942905 18977376 21047994 19254457 20501860 20583210 20405173 18754104 18978307 19499222 19090486 18644402 19642983 19426721 2422723 12771043 10737359 21278145 21071580 12112319 9163691 18648771 19073162 19850985 19833225 20434301 15885732
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.852876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.8518544905 18282651 9362446 16842330 18079962 18775883 19519916 16267830 18164116 19539802 18253720 18308698 19126423 19009564 17174075 17854601 21159647 18093689 3124819 19004024 2563599 17942915
MESH:D008114 Liver Neoplasms, Experimental kojic acid 14.8518544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.8512151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4218569708 20464547 18520028 18816296 17053015 20135361 20064080 6695378 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4220970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4211884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6411807958 17203775 11408345 16891317
MESH:D020149 Manganese Poisoning Estradiol 13.7419453300
MESH:D020149 Manganese Poisoning Manganese 13.7416551646 16568477 19453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009069 Movement Disorders Manganese 5.1616551646
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.057678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.619029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009410 Nerve Degeneration Manganese 4.3816551646
MESH:D009421 Nervous System Malformations Estradiol 10.0111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.5818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.5820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010300 Parkinson Disease Manganese 3.4211181820
MESH:D020734 Parkinsonian Disorders Manganese 4.6016140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0717292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0716740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.362093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1417053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00620 Pyruvate metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30725
    • No data
    No data
    Releated drug ID Related drug Name
    PA450626nicotine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB03680 - Tartronate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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