AutismKB 2.0

Annotation Detail for WDR3


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Basic Information Top
Gene Symbol:WDR3 ( FLJ12796 )
Gene Full Name: WD repeat domain 3
Band: 1p12
Quick LinksEntrez ID:10885; OMIM: 604737; Uniprot ID:WDR3_HUMAN; ENSEMBL ID: ENSG00000065183; HGNC ID: 12755
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of WDR3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of WDR3 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of WDR3 mRNAdecreases expression 20064835
D002995 Clofibric Acid Clofibric Acid affects the expression of WDR3 mRNAaffects expression 17602206
D004041 Dietary Fats Dietary Fats results in decreased expression of WDR3 mRNAdecreases expression 18042831
D008727 Methotrexate WDR3 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C041786 palm oil palm oil results in decreased expression of WDR3 mRNAdecreases expression 18042831
D011374 Progesterone Progesterone results in decreased expression of WDR3 mRNAdecreases expression 18037150
C017947 sodium arsenite sodium arsenite results in increased expression of WDR3 mRNAincreases expression 17879257
D013467 Sulindac Sulindac results in increased expression of WDR3 mRNAincreases expression 11906190
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.7614745880
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.4812039119
MESH:D058186 Acute Kidney Injury Sulindac 4.487897758
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.7820464547 20127859
MESH:D000230 Adenocarcinoma Sulindac 4.7811910360
MESH:D000236 Adenoma Benzo(a)pyrene 7.296695378
MESH:D000236 Adenoma Sulindac 7.2910223192
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.7612394442 11874996 15623613 19003578 17611924 11535846 16460482
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1716712894 17306315
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1317286800
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001913 Bowen's Disease Sulindac 5.6211207687
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715380490 15845082 15665606
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4120146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.4120435547
MESH:D001943 Breast Neoplasms Methotrexate 2.4116978400
MESH:D001943 Breast Neoplasms Progesterone 2.4116175315 15562024 17614352
MESH:D001943 Breast Neoplasms Sulindac 2.4116642371
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.673084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.6716507464 17306315 15276417
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7420419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7418572023
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1019524636 20056578
MESH:D003110 Colonic Neoplasms Sulindac 2.9412902858 12458338
MESH:D015179 Colorectal Neoplasms Sulindac 2.6911076880 10666051 18059344 11197048
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.6612039119 9562676
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.4019747007
MESH:D003882 Dermatomyositis Methotrexate 5.3220191521
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D003930 Diabetic Retinopathy Sulindac 5.3817621415 12861449
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.8621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8612594235 12958197 19370779 16081117 17562736 12705907 10774834 19085960 2444490 12153990 15619225 12540782 16393943 17522070 12392966 19923254 16485898 10663392 19164858 19739265 15968718 16227642 19420014 11421492 16781746 11287661 14725611 19416960 17906064 11743745 11461765 18071297 14550746 11834606 14986274 16177239 10915739 16109766 11739529 18713872 11529661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9817692515
MESH:D004715 Endometriosis Progesterone 10.0116134523
MESH:D004715 Endometriosis Sulindac 10.0115652904
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.8716530937
MESH:D004938 Esophageal Neoplasms Sulindac 4.8712235107
MESH:D005234 Fatty Liver Dietary Fats 3.4117967931 19551842 19004024 18296743
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.7114745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.3719069698
MESH:D005355 Fibrosis Dietary Fats 3.7418296743
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005764 Gastroesophageal Reflux Sulindac 5.2111910360
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9216452187
MESH:D006086 Graft vs Host Disease Methotrexate 5.3616518429
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007248 Infertility, Male sodium arsenite 3.1012646999 15346721
MESH:D007249 Inflammation Dietary Fats 8.9920412841
MESH:D007249 Inflammation Progesterone 8.9915869954
MESH:D007249 Inflammation Sulindac 8.993291741
MESH:D007333 Insulin Resistance Dietary Fats 3.2118457598 11836018
MESH:D007414 Intestinal Neoplasms Sulindac 4.8012584176 12663524 12628509 10223192 12351151 10213222
MESH:D007417 Intestinal Polyps Sulindac 5.1711245490 12394442
MESH:D007674 Kidney Diseases Acetaminophen 6.2712587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 6.2720008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1216705839
MESH:D007805 Language Development Disorders Methotrexate 5.299562676
MESH:D008103 Liver Cirrhosis Dietary Fats 7.2518296743
MESH:D008103 Liver Cirrhosis Methotrexate 7.2514986274
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.3212468960
MESH:D008107 Liver Diseases Acetaminophen 4.3716611625 11587558 19460945 12587719 19784758 12969438 19014921 16610002
MESH:D008107 Liver Diseases Sulindac 4.3714986274 16867024
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8620195826 21137059
MESH:D008113 Liver Neoplasms Clofibric Acid 7.8617602206
MESH:D008113 Liver Neoplasms sodium arsenite 7.8615276417 16712894
MESH:D008171 Lung Diseases sodium arsenite 3.2819095001
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.2918516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6518520028 20135361 17053015 20064080 6695378 20869020 18569708 18816296 20464547
MESH:D008175 Lung Neoplasms sodium arsenite 3.6519931552 15276417 17077188 16712894 17306315
MESH:D008175 Lung Neoplasms Sulindac 3.6519359593 15713900
MESH:D008223 Lymphoma Methotrexate 4.0717352296
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9717203775 11408345
MESH:D008545 Melanoma sodium arsenite 3.7519082730 16487513
MESH:D008545 Melanoma Sulindac 3.7516642371
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D052016 Mucositis Methotrexate 5.5217488658
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2811141357
MESH:D009369 Neoplasms sodium arsenite 5.2811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8820056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.2512854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.0118514411
MESH:D019636 Neurodegenerative Diseases Sulindac 9.0117266991 16850258
MESH:D009765 Obesity Dietary Fats 2.3221332399 18674790 19632207 20518802 20132043 11836018 17217161 16723640 18457598
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5912819281 16049721
MESH:D010051 Ovarian Neoplasms Progesterone 5.1117393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1117306315 15276417
MESH:D010146 Pain Acetaminophen 7.3916870215
MESH:D010146 Pain Sulindac 7.393291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.4011504793 16820089
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1517292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.1516039940
MESH:D011565 Psoriasis Methotrexate 3.4817410198
MESH:D051437 Renal Insufficiency Methotrexate 4.9317352296
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9619755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 5.9619524636 18572023
MESH:D013119 Spinal Cord Injuries Progesterone 4.5215862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9312854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013576 Syndactyly Methotrexate 5.239562676
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6516049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6517053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.6516452187 11723127 17306315 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9311813266
MESH:D014594 Uterine Neoplasms Sulindac 4.8018645019
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
Pathway ID Pathway Name
KEGG:03008 Ribosome biogenesis in eukaryotes
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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