AutismKB 2.0

Annotation Detail for GPR83


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Basic Information Top
Gene Symbol:GPR83 ( GIR,GPR72 )
Gene Full Name: G protein-coupled receptor 83
Band: 11q21
Quick LinksEntrez ID:10888; OMIM: 605569; Uniprot ID:GPR83_HUMAN; ENSEMBL ID: ENSG00000123901; HGNC ID: 4523
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GPR83 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of GPR83 mRNAincreases expression 11698613
D000661 Amphetamine Amphetamine results in increased expression of GPR83 mRNAincreases expression 15893650
D003907 Dexamethasone Dexamethasone results in increased expression of GPR83 mRNAincreases expression 15893650
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GPR83 mRNAdecreases expression 17555576
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of GPR83 mRNAaffects cotreatment|increases expression 17183730
D013629 Tamoxifen Tamoxifen affects the expression of GPR83 mRNAaffects expression 17555576
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of GPR83 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.828875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D019969 Amphetamine-Related Disorders Amphetamine 6.3915010207 18475255 16916582 16459022
MESH:D000855 Anorexia Amphetamine 5.2416101753 12005258 12183048 16084549
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Dexamethasone 7.8417659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.8415885639
MESH:D001321 Autistic Disorder Valproic Acid 1.9917688650 19232924 18396377 20603192 18940202 15238991 18177632 18316065 17157402 19460635 16609825 18985861 18775368 18558336 17507914
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D001943 Breast Neoplasms Tamoxifen 2.1816818667 16202921 18821012 18855134 19066611 19189210 20005174 19142967 18984771 18629630 17242785 19011961 18997820 17893378 20065188 19155303 19200415 19084267 19487384 11161223 19289846 19189212 17440819 15565566 19288272 18815881 19410462 20544844 16873071 15668708 17049068 19115204 20859285 18351453 18425577 19221464 19059307 20135344 16273361 19103187 19244106 20390343 21138602 17261762 21152245
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8416924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0515861022 17333356 17681005 17110522 16919318 11677210 16105132
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5215824018
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.9117728286
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.918888407 16575769 17688650
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.7012438553
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6919279558
MESH:D003967 Diarrhea Dexamethasone 3.977237001
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.231733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004485 Eczema Dexamethasone 4.7412438553
MESH:D004487 Edema Dexamethasone 3.6419703484
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.9019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1916202921 17893378 20544844 19155303
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.807562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D005221 Fatigue Amphetamine 5.9419890266
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.5715345470
MESH:D005234 Fatty Liver Tamoxifen 14.5714986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 14.5714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.147520565
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006948 Hyperkinesis Amphetamine 5.771977408 14960337
MESH:D006973 Hypertension Dexamethasone 3.0117042910
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9316612254
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Dexamethasone 5.6411099482 8960868
MESH:D007249 Inflammation Tamoxifen 5.6419457130
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2418625569
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008064 Lipidoses Tamoxifen 3.3217567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.7216718785
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.7218564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.2916684651
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms Dexamethasone 2.6811195469 15824018
MESH:D008175 Lung Neoplasms Tamoxifen 2.6818625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7611731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008881 Migraine Disorders Valproic Acid 3.3618765137 18803445
MESH:D009041 Motion Sickness Dextroamphetamine 5.901613127
MESH:D009101 Multiple Myeloma Dexamethasone 3.6716118317 15867202 15744524
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.989809623
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.9817596541
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819189210 19196722 19200415
MESH:D009436 Neural Tube Defects Valproic Acid 3.2716359493 8888407
MESH:D019636 Neurodegenerative Diseases Amphetamine 4.8515183010
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6621297632
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1720603192
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.2818379247 11700416
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.891511512 16876388 11044598 11738929 14763951 15475178 3137016 17978042
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.801977408
MESH:D013272 Stomach Diseases Dexamethasone 4.6615472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.7215138204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.438653321 16712894 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014605 Uveitis Dexamethasone 5.191336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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