AutismKB 2.0

Annotation Detail for MALT1


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Basic Information Top
Gene Symbol:MALT1 ( DKFZp434L132,MLT,MLT1 )
Gene Full Name: mucosa associated lymphoid tissue lymphoma translocation gene 1
Band: 18q21.32
Quick LinksEntrez ID:10892; OMIM: 604860; Uniprot ID:MALT1_HUMAN; ENSEMBL ID: ENSG00000172175; HGNC ID: 6819
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200005BCR signaling pathway
200062TCR signaling in naive CD8+ T cells
200022TCR signaling in naive CD4+ T cells
200026Canonical NF-kappaB pathway
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
1841Stomach cancer
2206Sicca syndrome
No data
No data
Desease Name
MALT lymphoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of MALT1 mRNAincreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MALT1 mRNAaffects expression 21346803
D001151 Arsenic Arsenic affects the expression of MALT1 mRNAaffects expression 18414638
D001151 Arsenic Arsenic results in increased expression of MALT1 mRNAincreases expression 19945496
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in increased expression of MALT1 mRNAaffects cotreatment|increases expression 17639512
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MALT1 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of MALT1 mRNAincreases expression 20106945
D005472 Fluorouracil Fluorouracil results in increased expression of MALT1 mRNAincreases expression 15109396
D005472 Fluorouracil MALT1 affects the susceptibility to Fluorouracilaffects response to substance 15067352
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in increased expression of MALT1 mRNAaffects cotreatment|increases expression 17639512
D012643 Selenium Selenium results in decreased expression of MALT1 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MALT1 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 15322242 14514962
MESH:D000230 Adenocarcinoma Fluorouracil 2.4617638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4817306315
MESH:D000740 Anemia Fluorouracil 9.2317963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.2311748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.4117084956
MESH:D020261 Arsenic Poisoning Arsenic 2.9116835338 18414634 16251483 12569548
MESH:D001260 Ataxia Telangiectasia Quercetin 5.2115336622
MESH:D050197 Atherosclerosis Arsenic 3.3412928151 19371607
MESH:D001327 Autoimmune Diseases Quercetin 4.6219761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.0316443354
MESH:D001943 Breast Neoplasms Fluorouracil 2.0316557594 19217205 18357371 15136595 18608205 16110121 16595493
MESH:D001943 Breast Neoplasms Quercetin 2.0318628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D002105 Cadmium Poisoning Quercetin 5.8116962696
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 8.6517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6516835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6815504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8316705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.8316507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.8317088986 17045692 16799960 16332177 17971768 18930000
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.8312508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1717234771
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0918695887
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.0217687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.0218986760 16757204 16280240 17066447
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2418640142
MESH:D006332 Cardiomegaly Quercetin 7.0919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0918670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 3.5615738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4616973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.826135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.8220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.8212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615340226 15668235 12621046 8697196 16354765
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9916340194 15001691 17287894 17725105 17018589 16510598 17172411 17016597 17169374 18772588
MESH:D003110 Colonic Neoplasms Quercetin 3.9917148506 19056647 15741050 17191121 11134977 16640504 19440933
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7018949393 15148649 17255274 18802399 15289873 16391804 14970324 17695437 17016601 16303861 18288408 18383874 18448328 17401013 17594712 16524972 17094418 20501625 18509181 17454858 16331619 16282729
MESH:D015179 Colorectal Neoplasms Quercetin 2.7018852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 5.7417323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8719496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 4.6816506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6817107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Selenium 6.4615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:C538011 Eales disease Ascorbic Acid 5.749068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6420426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6416481741 15173087 17638652 16337965 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 3.0319224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Cyclosporine 16.0812168785 12639820
MESH:D005355 Fibrosis Quercetin 16.0819474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0820067830
MESH:D005534 Foot Diseases Arsenic 5.826392382
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Quercetin 3.5019804834
MESH:D005910 Glioma Fluorouracil 6.3816145905
MESH:D005910 Glioma Quercetin 6.3817643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5015102660 18337622 15162350
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 7.1316080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.1311294989 10048152
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.5216863852 16490937
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 18606429 15340226 16959395 16354765
MESH:D006943 Hyperglycemia Quercetin 4.1918262572 11834736
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6217050553
MESH:D006973 Hypertension Arsenic 12.8616076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 12.8610903974
MESH:D006973 Hypertension Quercetin 12.8618356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 12.8618850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.8216093927
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007251 Influenza, Human Quercetin 11.9716624496
MESH:D007251 Influenza, Human Selenium 11.9716624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007627 Keloid Quercetin 5.1717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007642 Keratosis Arsenic 5.2312749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 6.438314463 10903974 18776723
MESH:D007674 Kidney Diseases Quercetin 6.4316962696
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2712371664
MESH:D007680 Kidney Neoplasms Fluorouracil 13.2716985049
MESH:D007938 Leukemia Quercetin 3.2317468513
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6617339181
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.4912741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4912878042
MESH:D008107 Liver Diseases Arsenic 2.5711134558
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.897678174
MESH:D008113 Liver Neoplasms Arsenic 14.8916368122
MESH:D008113 Liver Neoplasms Fluorouracil 14.8917045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms Quercetin 14.8918980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.8916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 15.032876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 15.0318544905
MESH:D008114 Liver Neoplasms, Experimental Quercetin 15.0319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.0312151625
MESH:D008171 Lung Diseases Ascorbic Acid 4.0616863852
MESH:D008175 Lung Neoplasms Arsenic 6.8119168569 17306315 17976673
MESH:D008175 Lung Neoplasms Ascorbic Acid 6.8116401635
MESH:D008175 Lung Neoplasms Fluorouracil 6.8115246190
MESH:D008175 Lung Neoplasms Quercetin 6.8116280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.8111884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7618986760 16757204
MESH:D009203 Myocardial Infarction Quercetin 3.0519595682
MESH:D017202 Myocardial Ischemia Arsenic 9.4715371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.4712213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.9219207477
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.1018551238 7678174
MESH:D009369 Neoplasms Fluorouracil 5.5516928823 18600527 18239605
MESH:D009369 Neoplasms Quercetin 5.5515185748
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects Arsenic 3.5616620997
MESH:D020078 Neurogenic Inflammation Arsenic 11.3117056641
MESH:D020078 Neurogenic Inflammation Quercetin 11.3117929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D009765 Obesity Ascorbic Acid 3.1717217161
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5916049721
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4019495926
MESH:D010051 Ovarian Neoplasms Arsenic 5.3017306315
MESH:D010051 Ovarian Neoplasms Quercetin 5.3019005980
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6615113037 16929163 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Quercetin 5.6616965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3816093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.2315371236 6392382 16905509
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.6212371664
MESH:D011230 Precancerous Conditions Quercetin 9.6219056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311222880 11399792 11896295 11118676
MESH:D011471 Prostatic Neoplasms Arsenic 2.6616140617
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6619082440 18626508
MESH:D011471 Prostatic Neoplasms Quercetin 2.6617292933 14715546
MESH:D011507 Proteinuria Arsenic 4.1921343184
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.6014606601
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1615538739 16160472 18722050 18286688
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.3516849425
MESH:D012554 Schistosomiasis japonica Quercetin 5.8116862918
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6418551238
MESH:D012871 Skin Diseases Arsenic 5.4519834688 17548696 16702368 17050553 6392382 15952646 16759981 17938729 18709164 17453740 16353154
MESH:D012871 Skin Diseases Ascorbic Acid 5.4518709164
MESH:D012878 Skin Neoplasms Arsenic 5.9517976673 16251483 17029826 17050553 15504454 19538983
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9516192470
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017498489 18567086 16951190 17522103 19015929 18396642 15786421 16424979 17172411 19084572
MESH:D013276 Stomach Ulcer Ascorbic Acid 4.0618726076
MESH:D020521 Stroke Ascorbic Acid 4.4316517955 16403987
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7716049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.7717976673 18640142 11144890 19429237 19322015 15987713 17306315
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.7716720314
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014652 Vascular Diseases Arsenic 4.9717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:04662 B cell receptor signaling pathway
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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