AutismKB 2.0

Annotation Detail for ADCY3


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Basic Information Top
Gene Symbol:ADCY3 ( AC3,KIAA0511 )
Gene Full Name: adenylate cyclase 3
Band: 2p23.3
Quick LinksEntrez ID:109; OMIM: 600291; Uniprot ID:ADCY3_HUMAN; ENSEMBL ID: ENSG00000138031; HGNC ID: 234
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04020Calcium signaling pathway
hsa05414Dilated cardiomyopathy
hsa04540Gap junction
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa00230Purine metabolism
hsa04971Gastric acid secretion
hsa04114Oocyte meiosis
hsa04740Olfactory transduction
hsa04062Chemokine signaling pathway
hsa05110Vibrio cholerae infection
Pathway IDPathway Name
Signaling by GPCR
Synaptic Transmission
Signalling by NGF
Transmembrane transport of small molecules
Opioid Signalling
Integration of energy metabolism
Pathway IDPathway Name
200036LPA4-mediated signaling events
200004Endothelins
200011LPA receptor mediated events
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00019Endothelin signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1856Obesity
1904Diabetes mellitus
1943Adenocarcinoma
Desease Name
height
CHEMDEPENDENCY
alcohol dependence
DEVELOPMENTAL
Desease Name
Height
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADCY3 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of ADCY3 mRNAaffects expression 17331233
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ADCY3 mRNAaffects cotreatment|increases expression 18164116
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ADCY3 mRNAdecreases expression 12414654
D002220 Carbamazepine Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY3 protein]affects binding|decreases reaction|increases activity 19922557
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of ADCY3 mRNAaffects cotreatment|affects expression 18636392
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ADCY3 mRNAaffects cotreatment|increases expression 18164116
D005557 Formaldehyde Formaldehyde results in increased expression of ADCY3 mRNAincreases expression 14756816
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of ADCY3 mRNAdecreases expression 12414654
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of ADCY3 mRNAaffects cotreatment|affects expression 18636392
C071262 SK&F 82958 Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY3 protein]affects binding|decreases reaction|increases activity 19922557
C071262 SK&F 82958 [SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY3 proteinaffects binding|increases activity 19922557
D024483 Vitamin K 3 Vitamin K 3 results in decreased expression of ADCY3 mRNAdecreases expression 12414654
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 4.708986270
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury Chlorine 4.4420601635
MESH:D000236 Adenoma beta-Naphthoflavone 7.0819389873
MESH:D000236 Adenoma Diethylnitrosamine 7.0810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0517162532 19052882 18056438 19061943 17620307 16434500
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5815570426
MESH:D001249 Asthma Ozone 2.6617854713 16373670
MESH:D001714 Bipolar Disorder Carbamazepine 4.1820046352 17594078
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8217474063
MESH:D001943 Breast Neoplasms Formaldehyde 2.8215986119
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7617626835 15516495 16777450 18315731 14754758 18417511 19059883
MESH:D002100 Cachexia Ozone 4.8916183385
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8616288022 17055752 16878318 20514400 19394651 16830150 18785209 16502159 16807293 16328049 17978847 20214788 18393292 16935385 17428255 16569478 19052882 20512989 18788625 19919837 19335982 20727157 17173139 16698587 20935162 16540662 3084413 10672840 17761372 18978308 19519916 19208518 20084675 19822196 18210153 19107877 19539802 19383236 17138121 20524982 19171122 17162532 3581430 20101231 19701751 20007298 18506893 18056438 16681979 18691550 18971187 18494052 20432363 19418558 16779866 11831363 18665156 21159647 10737359
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.5916936243
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9317174075 7505956 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7819052882
MESH:D016770 Ciliophora Infections Formaldehyde 5.8212113305
MESH:D019465 Craniofacial Abnormalities Carbamazepine 2.959014606
MESH:D017449 Dermatitis, Allergic Contact Formaldehyde 4.8415932584 16958921 12081698 14996049 15059100
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.5811748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.4715057820 16538175 20216337 16538176
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 4.4517465707
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.4519107877
MESH:D004362 Drug Toxicity Carbamazepine 4.5420216337
MESH:D004417 Dyspnea Chlorine 4.8020016425
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 4.8617654737
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.3816415921 16538176 20485159 18855540 19915237
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.3517275665
MESH:D004828 Epilepsies, Partial Carbamazepine 5.1515008574 16628512 17116037
MESH:D004827 Epilepsy Carbamazepine 4.047988514 9014606 17465707 17178248 821787 19700373 18234410 19439326 19620853 20417680
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.497750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 5.2715276670 3659116
MESH:D004916 Erythromelalgia Carbamazepine 5.8819549232
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D005076 Exanthema Carbamazepine 5.6220485159
MESH:D005141 Eyelid Diseases Formaldehyde 6.5514996049
MESH:D005234 Fatty Liver Diethylnitrosamine 3.2921071580 20387270
MESH:D005393 Fish Diseases Formaldehyde 5.7812113305
MESH:D005739 Gas Poisoning Chlorine 5.1820016425
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.8210459572
MESH:D006965 Hyperplasia Carbamazepine 5.3518773962
MESH:D007249 Inflammation Diethylnitrosamine 2.4318785209
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.3816518626
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8818665156 18407596 20032147 19638242 18522880
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1217034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 4.9019389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.9020434301 20501860 19996281 21071580 21167192 16942905 18648771 19642983 20583210 19090486 19850985 15885732 20101389 19427195 19254457 2862719 19294768 2422723 19255062 19073162 18977376 19551842 15175105 18978307 19426721 20118626 19638242 20452335 12112319 9163691 20405173 19833225 18754104 10737359 19812893 18644402 19690152 12771043 21278145 20492335 21047994 20137499 19499222 19256749
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 6.3518164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.3517174075 18079962 19126423 18093689 19519916 17942915 19004024 19539802 18253720 3124819 18164116 18544905 9362446 19009564 2563599 16267830 21159647 18775883 18308698 16842330 18282651 17854601
MESH:D008171 Lung Diseases Ozone 3.458266340 19066396
MESH:D055370 Lung Injury Asbestos, Crocidolite 9.7117365036
MESH:D055370 Lung Injury Ozone 9.7120417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.606695378 21163286 20970405 20512841
MESH:D008175 Lung Neoplasms Ozone 2.607614698 8597069
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5916628512
MESH:D008545 Melanoma Vitamin K 3 3.1919082730
MESH:D008607 Mental Retardation Carbamazepine 3.769014606
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2218303189 16166281 16966607
MESH:D008679 Metaplasia Ozone 5.2810496685
MESH:D009224 Myotonia Congenita Carbamazepine 5.6220399394
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.609029167 3581430
MESH:D009421 Nervous System Malformations Carbamazepine 5.0416990009
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D009669 Nose Neoplasms Formaldehyde 5.494038687
MESH:D010018 Osteomalacia Carbamazepine 5.6217016548
MESH:D010146 Pain Carbamazepine 4.1215215642
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D010212 Papilloma Hydrogen Peroxide 4.2212065085
MESH:D010267 Parapsoriasis Carbamazepine 5.8416538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 6.0817145499 17679678
MESH:D010538 Peritonitis Ozone 4.2716369182
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0310923243
MESH:D011014 Pneumonia Ozone 4.5518929643 18381685 18007984
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.652563599
MESH:D011248 Pregnancy Complications Carbamazepine 5.299014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 5.049014606
MESH:D019310 Pseudolymphoma Carbamazepine 5.7712752131 9591791
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0617322281 17365031 15814490 17975199
MESH:D012120 Respiration Disorders Chlorine 5.3918579056
MESH:D012595 Scleroderma, Systemic Formaldehyde 5.9814979077
MESH:D012640 Seizures Carbamazepine 3.8615946322 16180713 16876388 9046859 9844417 19414003 16938433
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 6.1312065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.138532709
MESH:D012893 Sleep Disorders Carbamazepine 5.2719414003
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.3518855540 16538176 15057820 16415921 19694795 20485159 19915237
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.077505956
Pathway ID Pathway Name
KEGG:04976 Bile secretion
KEGG:04020 Calcium signaling pathway
KEGG:04062 Chemokine signaling pathway
KEGG:05414 Dilated cardiomyopathy
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:04724 Glutamatergic synapse
KEGG:04912 GnRH signaling pathway
REACT:1505 Integration of energy metabolism
KEGG:04916 Melanogenesis
KEGG:04740 Olfactory transduction
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
KEGG:04972 Pancreatic secretion
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:00230 Purine metabolism
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
KEGG:04270 Vascular smooth muscle contraction
KEGG:04962 Vasopressin-regulated water reabsorption
KEGG:05110 Vibrio cholerae infection
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164741137
    • No data
    No data
    Releated drug ID Related drug Name
    PA165290926fluticasone/salmeterol
    PA451300salmeterol
    PA164749238exenatide
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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