AutismKB 2.0

Annotation Detail for SUGT1


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Basic Information Top
Gene Symbol:SUGT1 ( SGT1 )
Gene Full Name: SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
Band: 13q14.3
Quick LinksEntrez ID:10910; OMIM: 604098; Uniprot ID:SUGT1_HUMAN; ENSEMBL ID: ENSG00000165416; HGNC ID: 16987
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04621NOD-like receptor signaling pathway
No data
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No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SUGT1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SUGT1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of SUGT1 mRNAaffects expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of SUGT1 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SUGT1 mRNAdecreases expression 20458559
C018021 cobaltous chloride cobaltous chloride results in decreased expression of SUGT1 proteindecreases expression 16622835
D016572 Cyclosporine Cyclosporine results in increased expression of SUGT1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SUGT1 mRNAincreases expression 17942748
C029938 nickel sulfate nickel sulfate results in decreased expression of SUGT1 mRNAdecreases expression 16780908
C029938 nickel sulfate nickel sulfate results in increased expression of SUGT1 mRNAincreases expression 16780908
D014212 Tretinoin Tretinoin results in decreased expression of SUGT1 mRNAdecreases expression 16604517
C025643 vinclozolin vinclozolin affects the expression of SUGT1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury nickel sulfate 4.4611954676 16100012 19131640 12718980
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3919825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3914692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7519015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4815885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6416206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.6416197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.6616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.6616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.663581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.663084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.6615553829 14691202 15073043 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.661917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3216051514 16096774
MESH:D002386 Cataract Acetaminophen 7.4810977129
MESH:D002386 Cataract Tretinoin 7.4817460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.706135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.707505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.7012371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.009022650 19486331
MESH:D002779 Cholestasis Cyclosporine 14.0019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.0016919318 17333356 16105132 11677210 17681005 15861022 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tretinoin 2.729407595
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7110525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.7114991402 16925845 9664655 9211117 8800419 10589399 9142499 17551590 9224671 9125849
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 12.818156756 12868966 18759878 11906362 8970840 11298694 2524372 14531868
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 12.8116823706 15059100 11298694
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 12.8116780908 16823706 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.643621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.288291058 9653073 11289319 16192314 6482804 1440618 18648102 9328219 9022650 7440962 18692083 6679447 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2810915739 11743745 12705907 14986274 11287661 19420014 16781746 12392966 17906064 16109766 15968718 19370779 16177239 19164858 12153990 2444490 19416960 11834606 18071297 16393943 18713872 12594235 14725611 17562736 19739265 16485898 11461765 10663392 19085960 12958197 16081117 11421492 17522070 11739529 10774834 15619225 12540782 16227642 19923254 11529661 14550746
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004489 Edema, Cardiac Tretinoin 4.6818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1916569247
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.583581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5812903497
MESH:D005124 Eye Abnormalities Tretinoin 3.689664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 13.9015073043
MESH:D005234 Fatty Liver Cyclosporine 13.9019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.9015345470
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Cyclosporine 9.2812168785 12639820
MESH:D005355 Fibrosis Tretinoin 9.2817994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.969664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006930 Hyperalgesia Acetaminophen 8.0016870215
MESH:D006930 Hyperalgesia Tretinoin 8.0016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9617937319
MESH:D007248 Infertility, Male vinclozolin 6.9616467254
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.249022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 4.0417551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.0515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.0518776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.7516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.7516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.756582329
MESH:D007680 Kidney Neoplasms Cyclosporine 18.7512371664
MESH:D007938 Leukemia arsenic trioxide 6.5515070760
MESH:D007938 Leukemia Tretinoin 6.5517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.9519077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.9516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9620471514 17050201 16968895 16467208 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9617596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.9316891316 17217047 16823087 17869043 17649720 17712046 15213294 16330433 19075265 11161223 15622746 12712474 15336539 16112521 9834237 16331271 17107899 19225113 15748426 16966277 12018890 19642359 11468182 19035177 12679006
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.9316935935 19029980 16788101 17712046 17649720 9834237 16823087 16766008 19642359 16331271 17361223 17339181 17294898 17217047 19035177 12679006 19075265 19225113 17301526 17506722 16891316 17107899 17368321 16140955 15748426
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6619460945 12969438 11587558 16611625 16610002 19014921 19784758 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.767678174
MESH:D008113 Liver Neoplasms arsenic trioxide 4.7614682389
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.352876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.351399818 6587162 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.3520377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8619825857 11798837
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2015949261 14977855 19417148 11468182 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.6416105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.6417596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.0018551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms Tretinoin 2.4716946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Tretinoin 3.949125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.646679447
MESH:D009436 Neural Tube Defects arsenic trioxide 12.6410525206
MESH:D009436 Neural Tube Defects Tretinoin 12.649142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.8516049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.8516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.856482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0019769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0016936753
MESH:D010146 Pain Acetaminophen 6.9816870215
MESH:D010146 Pain Tretinoin 6.9816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4415580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0918042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2519131511
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1818551238
MESH:D012878 Skin Neoplasms Tretinoin 2.6716467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4917007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.4917261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.606582329 1399818 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.6019014326
MESH:D013964 Thyroid Neoplasms Tretinoin 12.6016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.3316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.3316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.338074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.3311780464 12845720 12973940 20435036
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6815869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:04621 NOD-like receptor signaling pathway
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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