AutismKB 2.0

Annotation Detail for UTS2


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Basic Information Top
Gene Symbol:UTS2 ( PRO1068,U-II,UCN2,UII )
Gene Full Name: urotensin 2
Band: 1p36.23
Quick LinksEntrez ID:10911; OMIM: 604097; Uniprot ID:UTS2_HUMAN; ENSEMBL ID: ENSG00000049247; HGNC ID: 12636
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
2032Kidney disease
2091Hypertension
2116Adrenal gland tumor
2236Cardiovascular disease
2257Hemolytic-Uremic syndrome
Desease Name
CARDIOVASCULAR
myocardial infarct
glucose tolerance insulin
hypertension
METABOLIC
diabetes, gestational
diabetes, type 2
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of UTS2 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of UTS2 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UTS2 mRNAaffects expression 16483693
D000968 Antimycin A Antimycin A results in increased expression of UTS2 mRNAincreases expression 19304788
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of UTS2 mRNAincreases expression 21056072
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of UTS2 proteinincreases expression 21056072
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of UTS2 mRNAaffects binding|increases activity|increases expression 19710929
C025299 polyphenols polyphenols results in decreased expression of UTS2 mRNAdecreases expression 16293270
D012402 Rotenone Rotenone results in increased expression of UTS2 mRNAincreases expression 19304788
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000236 Adenoma Diethylnitrosamine 2.986695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.2417620307 16434500 18056438 19061943 19052882 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2416434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0318057881 20041841 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 4.0819698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.9019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.9019483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9417173139 19107877 20084675 16681979 3084413 20935162 18506893 17162532 17761372 16540662 16288022 20727157 19701751 16830150 19539802 18691550 18393292 18056438 17978847 18494052 19519916 19919837 11831363 16935385 19394651 17055752 18785209 19383236 20524982 18210153 17138121 16878318 16807293 19052882 19171122 20007298 21159647 20101231 20514400 18971187 3581430 19335982 18788625 19418558 16779866 18665156 10672840 20214788 20512989 16569478 19208518 18978308 20432363 16328049 17428255 19822196 10737359 16698587 16502159
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9615710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4218974383
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.012727394 7505956 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003110 Colonic Neoplasms polyphenols 2.7016293270
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.5416393943 12958197 17522070 14550746 17562736 19416960 12392966 17906064 19164858 11461765 19370779 11529661 12594235 16227642 2444490 11834606 11421492 18713872 15619225 14725611 19420014 11743745 19923254 12705907 16485898 16081117 16177239 19085960 15968718 11287661 16109766 16781746 19739265 14986274 12153990 11739529 18071297 10915739 10663392 10774834 12540782
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.5415265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.5419107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.5419370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005234 Fatty Liver Amiodarone 14.6014986274
MESH:D005234 Fatty Liver Diethylnitrosamine 14.6021071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 14.6019236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly Amiodarone 9.6215265979
MESH:D006529 Hepatomegaly pirinixic acid 9.6218467677 16221962 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.128137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007037 Hypothyroidism Amiodarone 4.8218020914 17991464
MESH:D007249 Inflammation Diethylnitrosamine 5.7118785209
MESH:D007249 Inflammation polyphenols 5.7116366677
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D008064 Lipidoses Amiodarone 3.6817567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9419638242 18522880 18665156 20032147 18407596
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 6.8816611625 19784758 19014921 19460945 12969438 16610002 12587719 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 6.8817034775
MESH:D008107 Liver Diseases polyphenols 6.8816698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.7015885732 18644402 20101389 20405173 19294768 19812893 16942905 19690152 15175105 19426721 19996281 19499222 20501860 21278145 19255062 12771043 18648771 20137499 19256749 20452335 20583210 12112319 19090486 20492335 18977376 10737359 19850985 19638242 19427195 21047994 20434301 18978307 20118626 19073162 19254457 2862719 19642983 2422723 9163691 19551842 21167192 21071580 18754104 19833225
MESH:D008113 Liver Neoplasms pirinixic acid 4.7020007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7718079962 19519916 18544905 19009564 17942915 19004024 18253720 17854601 18775883 18093689 18164116 16267830 19539802 3124819 19126423 17174075 16842330 2563599 9362446 21159647 18308698 18282651
MESH:D008133 Long QT Syndrome Amiodarone 3.7617391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.5312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8518516814
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 20512841 21163286 6695378
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009181 Mycoses Amiodarone 5.2817974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.653581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009410 Nerve Degeneration Rotenone 4.0618619942 17356569 15790535
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D010300 Parkinson Disease Rotenone 3.0511535288 18191903 11445065 16140633 18619942 19232380 19114014 15451049 16412576
MESH:D020734 Parkinsonian Disorders Rotenone 4.3018197244 15927086 15795934 15574749
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9312490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4218724381
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013276 Stomach Ulcer Amiodarone 3.5518087811
MESH:D013610 Tachycardia Amiodarone 4.5711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4719225199
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.6317997062
MESH:D013959 Thyroid Diseases Amiodarone 5.1319731979
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
MESH:D013971 Thyrotoxicosis Amiodarone 5.1718020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.5317467628 11989578
MESH:D014581 Urticaria Acetaminophen 3.2410982225
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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