AutismKB 2.0

Annotation Detail for EHMT2


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Basic Information Top
Gene Symbol:EHMT2 ( BAT8,C6orf30,DKFZp686H08213,FLJ35547,G9A,KMT1C,NG36 )
Gene Full Name: euchromatic histone-lysine N-methyltransferase 2
Band: 6p21.33
Quick LinksEntrez ID:10919; OMIM: 604599; Uniprot ID:EHMT2_HUMAN; ENSEMBL ID: ENSG00000204371; HGNC ID: 14129
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00310Lysine degradation
No data
Pathway IDPathway Name
200102Regulation of Androgen receptor activity
No data
Pathway IDPathway Name
500575RNA Polymerase I Transcription Initiation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
Desease Name
CANCER
overall effect
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of EHMT2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of EHMT2 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of EHMT2 mRNAaffects expression 17562736
C015001 arsenite arsenite results in increased expression of EHMT2 mRNAincreases expression 18321869
C015001 arsenite arsenite results in increased expression of EHMT2 proteinincreases expression 18321869
D001241 Aspirin Aspirin results in increased expression of EHMT2 mRNAincreases expression 11906190
C518299 BIX 01294 BIX 01294 results in decreased activity of EHMT2 proteindecreases activity 19531572
C014347 decitabine EHMT2 protein affects the susceptibility to decitabineaffects response to substance 19531572
D004317 Doxorubicin Doxorubicin promotes the reaction [EHMT2 protein binds to BIRC5 promoter]affects binding|increases reaction 17124180
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EHMT2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EHMT2 mRNAaffects cotreatment|increases expression 17942748
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of EHMT2 mRNAaffects cotreatment|increases expression 17183730
D007657 Ketone Bodies Ketone Bodies results in increased expression of EHMT2 mRNAincreases expression 16807920
D009532 Nickel Nickel results in decreased expression of and results in decreased activity of EHMT2 proteindecreases activity|decreases expression 16648469
D010126 Ozone Ozone results in decreased expression of EHMT2 mRNAdecreases expression 17460151
D013467 Sulindac Sulindac results in decreased expression of EHMT2 mRNAdecreases expression 11906190
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EHMT2 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin EHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to POU5F1 promoter]]affects binding|increases reaction 16415856
D014212 Tretinoin EHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to ZFP42 promoter]]affects binding|increases reaction 16415856
D014212 Tretinoin EHMT2 protein promotes the reaction [Tretinoin results in increased methylation of POU5F1 promoter]increases methylation|increases reaction 16415856
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of EHMT2 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid Valproic Acid results in decreased expression of EHMT2 mRNAdecreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.5014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2814514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9119490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D058186 Acute Kidney Injury Sulindac 4.297897758
MESH:D055371 Acute Lung Injury Nickel 4.5616166738
MESH:D000230 Adenocarcinoma Doxorubicin 7.1917418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1914692618
MESH:D000230 Adenocarcinoma Sulindac 7.1911910360
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.973712494
MESH:D000236 Adenoma Sulindac 6.9710223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3716835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.5816460482 11535846 19003578 11874996 17611924 12394442 15623613
MESH:D000419 Albuminuria Doxorubicin 4.5321441931
MESH:D000505 Alopecia Tretinoin 3.6015955085
MESH:D000544 Alzheimer Disease Ozone 2.4315513908
MESH:D000550 Amblyopia Valproic Acid 5.2317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5517497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1615885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.1616412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.6515570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.6516292516
MESH:D001249 Asthma Ozone 4.9317854713 16373670
MESH:D001249 Asthma Tretinoin 4.9316456186
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.6820485159 12372130
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8520603192 18396377 18558336 17157402 18985861 18940202 15238991 18775368 19232924 16609825 17507914 18177632 19460635 17688650 18316065
MESH:D001471 Barrett Esophagus Tretinoin 4.3916935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.021440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.0620046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.8816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.9815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.988888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.7014601052
MESH:D001913 Bowen's Disease Sulindac 5.3511207687
MESH:D001932 Brain Neoplasms Aspirin 9.0815481559
MESH:D001932 Brain Neoplasms Doxorubicin 9.0817150277
MESH:D001943 Breast Neoplasms Aspirin 3.7715161893
MESH:D001943 Breast Neoplasms decitabine 3.7719208741 18320071
MESH:D001943 Breast Neoplasms Doxorubicin 3.7716096432 16322301 18695136 16826403 16264153 18234424 18628466 15634643 15994142 16935488 15993339 15692762 15939500 17369602 15136595 16115903 18382427 16595493 19526202 17983394 15567936 17426702 15668708 11325840
MESH:D001943 Breast Neoplasms Nickel 3.7715986119
MESH:D001943 Breast Neoplasms Sulindac 3.7716642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7720435547
MESH:D001943 Breast Neoplasms Tretinoin 3.7716873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6619059883 18315731 16777450 18417511 14754758 15516495 17626835
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5816813970
MESH:D002100 Cachexia Ozone 4.7316183385
MESH:D002276 Carcinoid Tumor Doxorubicin 4.8116051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1616168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.8416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.847296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.843084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.8417876044 18059187 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.841917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.527296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.521485588 16201981
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.5819215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.586189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.5816096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5117007740 16109756 15792986 15505089 17974986 15476868 15811867 17308081 16278810 17519947 16952015 16731534 17928571 16651473 16612575 17351982 17382496 17924179 16455267 16269455 16242529 18627295 17131338 16364871 17329180
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9416243910 17334414
MESH:D002386 Cataract Acetaminophen 7.1810977129
MESH:D002386 Cataract Tretinoin 7.1817460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.616135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.617505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7020734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.819022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8116919318 15861022 17681005 17110522 16105132 11677210 17333356
MESH:D002822 Choriocarcinoma Tretinoin 5.1616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7412621046 15340226 16354765 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 5.749407595
MESH:D003092 Colitis Tretinoin 3.6917035595
MESH:D003110 Colonic Neoplasms arsenite 8.4015037631
MESH:D003110 Colonic Neoplasms Aspirin 8.4012411196
MESH:D003110 Colonic Neoplasms decitabine 8.4017616700
MESH:D003110 Colonic Neoplasms Sulindac 8.4012458338 12902858
MESH:D015179 Colorectal Neoplasms Aspirin 4.8717047198
MESH:D015179 Colorectal Neoplasms decitabine 4.8718981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.8718802399 18259882
MESH:D015179 Colorectal Neoplasms Sulindac 4.8710666051 11197048 11076880 18059344
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7520055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.758800419 10589399 14991402 17551590 9125849 16925845 9664655 9224671 9211117 9142499
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.758888407 17688650 16575769
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0018551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.202524372 18759878 8970840 12868966 11298694 8156756 11906362 14531868
MESH:D017449 Dermatitis, Allergic Contact Nickel 7.2019470301 17100760 17244072
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 9.482952479 3621924
MESH:D003877 Dermatitis, Contact Nickel 9.482952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003930 Diabetic Retinopathy Sulindac 5.1617621415 12861449
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.1921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.1918692083 6482804 8291058 11289319 18289764 18648102 7440962 9022650 9328219 9653073 16192314 6679447 1440618
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.1919923254 16177239 12540782 15968718 16485898 18713872 12153990 16109766 10774834 11739529 14550746 17906064 12594235 11743745 17562736 11834606 2444490 19085960 19370779 14725611 16393943 12705907 10663392 18071297 19164858 16081117 11529661 11461765 12392966 19416960 11421492 16781746 12958197 10915739 15619225 19739265 19420014 16227642 17522070 11287661 14986274
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 15.1917416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.1920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.191733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Doxorubicin 8.0618602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0611462148
MESH:D004421 Dystonia Valproic Acid 4.031851702
MESH:D004487 Edema Aspirin 7.0017259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.9518230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.9518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1712538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1219294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.5417359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.5416569247
MESH:D004715 Endometriosis Sulindac 9.1315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.1310568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1618037988
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.1417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.923922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9220417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.577562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.287750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.063659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.763581430
MESH:D004938 Esophageal Neoplasms Sulindac 4.7612235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.7816938888 9664655
MESH:D005234 Fatty Liver arsenite 13.0918296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.0915345470
MESH:D005234 Fatty Liver Valproic Acid 13.0919224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.118888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.026705139
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.4714745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.7619069698
MESH:D018222 Fibromatosis, Aggressive Sulindac 11.7619069698
MESH:D005355 Fibrosis arsenite 14.7718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.7720067830
MESH:D005355 Fibrosis Tretinoin 14.7717994277
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.9911910360
MESH:D005909 Glioblastoma Aspirin 11.9512870263
MESH:D005909 Glioblastoma Doxorubicin 11.9517150277
MESH:D005909 Glioblastoma Tretinoin 11.9517312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.027505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006261 Headache Aspirin 4.9615240983
MESH:D006258 Head and Neck Neoplasms decitabine 12.9119215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.9115692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.9116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.5014991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 3.4716495754 16330681 16244372 17888722 18006777 16144979 14766674 16707910 17875725 12587719 18674790 16244371 16879835
MESH:D006333 Heart Failure Doxorubicin 3.3317481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8815692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.506705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8815340226 12621046 16120746
MESH:D015658 HIV Infections Nickel 3.8017263646
MESH:D006689 Hodgkin Disease Doxorubicin 3.3915147373 17606976 18501091
MESH:D006849 Hydrocephalus Valproic Acid 4.8617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0515340226 16354765 8697196 16959395 18606429
MESH:D012001 Hyperacusis Aspirin 5.7615240983
MESH:D006930 Hyperalgesia Acetaminophen 7.5716870215
MESH:D006930 Hyperalgesia Tretinoin 7.5716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5516778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9215034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.6116612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male decitabine 6.6717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6717937319
MESH:D007249 Inflammation Nickel 8.4816166738
MESH:D007249 Inflammation Sulindac 8.483291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.4812878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 3.7517994277
MESH:D007414 Intestinal Neoplasms Sulindac 4.6210223192 12584176 10213222 12351151 12628509 12663524
MESH:D007417 Intestinal Polyps Sulindac 4.9711245490 12394442
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.028074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8716580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8715992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 6.0212587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 6.0215369732 15699352 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.1316707910
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.3016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.306582329
MESH:D007938 Leukemia decitabine 6.3918980019 19235587
MESH:D007938 Leukemia Tretinoin 6.3917143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1616085563
MESH:D007951 Leukemia, Myeloid decitabine 9.5019117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 9.5016932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.1319010910 18460780 17679729 18704418 19387464 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.1317596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 6.1316294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4618055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.149834237 12679006 17712046 16331271 17361223 17506722 16823087 16140955 19029980 16766008 16788101 17368321 19075265 17217047 16935935 15748426 19035177 17294898 16891316 17649720 17107899 19642359 17339181 19225113 17301526
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.299224671
MESH:D008103 Liver Cirrhosis arsenite 3.4118296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 8.4615034207 9327722
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 8.4612468960
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.4916439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4916248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 4.2312587719 12969438 11587558 19014921 16611625 19460945 16610002 19784758
MESH:D008107 Liver Diseases Sulindac 4.2314986274 16867024
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2216871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.347678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.016135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.016587162 598648 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.0116842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.0112151625
MESH:D008171 Lung Diseases Ozone 3.3619066396 8266340
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2617228818
MESH:D055370 Lung Injury Ozone 3.8320417186
MESH:D008175 Lung Neoplasms arsenite 6.5916809336
MESH:D008175 Lung Neoplasms Doxorubicin 6.5917418594 6189445
MESH:D008175 Lung Neoplasms Ozone 6.598597069 7614698
MESH:D008175 Lung Neoplasms Sulindac 6.5919359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5911884234 19555203
MESH:D008223 Lymphoma decitabine 7.6719470736
MESH:D008223 Lymphoma Doxorubicin 7.6716098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7717654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5515621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.0215458769
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma decitabine 7.3416505122 17785578
MESH:D008545 Melanoma Doxorubicin 7.3416827129
MESH:D008545 Melanoma Sulindac 7.3416642371
MESH:D008545 Melanoma Tretinoin 7.3416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008591 Meningomyelocele Tretinoin 4.4116940565
MESH:D008654 Mesothelioma Doxorubicin 3.0517638057
MESH:D008679 Metaplasia Ozone 5.1110496685
MESH:D008881 Migraine Disorders Aspirin 7.8115240983
MESH:D008881 Migraine Disorders Valproic Acid 7.8118765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4815792986
MESH:D052016 Mucositis Doxorubicin 4.7817415656
MESH:D009101 Multiple Myeloma decitabine 3.3318172295
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.018888407
MESH:D009190 Myelodysplastic Syndromes decitabine 12.2718608210 19157545 16882708 19010910
MESH:D009190 Myelodysplastic Syndromes Tretinoin 12.2717596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 12.2717596541
MESH:D009203 Myocardial Infarction Aspirin 6.2012692751
MESH:D009203 Myocardial Infarction Doxorubicin 6.2015857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D009325 Nausea Aspirin 5.2115240983
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8518551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.823581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.8218259882
MESH:D009369 Neoplasms decitabine 5.1519116145 19470736 17925555
MESH:D009369 Neoplasms Tretinoin 5.1516946489 16594593
MESH:D009389 Neovascularization, Pathologic arsenite 4.4015738583
MESH:D009401 Nephrosis Doxorubicin 4.7516899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.9816889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.4614600291
MESH:D009421 Nervous System Malformations Tretinoin 9.469125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.056679447
MESH:D009436 Neural Tube Defects Tretinoin 12.059142499
MESH:D009436 Neural Tube Defects Valproic Acid 12.0516359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 3.2515555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4618514411
MESH:D019636 Neurodegenerative Diseases Sulindac 8.4617266991 16850258
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.8216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.826482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.023988306
MESH:D010003 Osteoarthritis Aspirin 4.047009135
MESH:D012516 Osteosarcoma Doxorubicin 4.0915930896
MESH:D010051 Ovarian Neoplasms decitabine 4.9419331143 19259094
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9416936753
MESH:D010146 Pain Acetaminophen 16.0316870215
MESH:D010146 Pain Aspirin 16.036995502 6363464
MESH:D010146 Pain Sulindac 16.033291741
MESH:D010146 Pain Tretinoin 16.0316870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.7319294695
MESH:D010190 Pancreatic Neoplasms Sulindac 8.7311504793 16820089
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.7315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.477296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.5311156591
MESH:D010538 Peritonitis Ozone 4.1216369182
MESH:D020795 Photophobia Aspirin 5.7615240983
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.476228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1617983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1617638057
MESH:D011014 Pneumonia Ozone 4.3918381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4411896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.4420603192
MESH:D055728 Primary Myelofibrosis decitabine 4.7117616702
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5616729912 15749863 15897917 16868541 18437689 16888761
MESH:D011507 Proteinuria Tretinoin 3.5916636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.5411422049 12752131
MESH:D011625 Pterygium Tretinoin 4.7816723453
MESH:D051437 Renal Insufficiency Doxorubicin 4.2117922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.363692021
MESH:D012208 Rhabdomyosarcoma decitabine 18.4319155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 18.4316116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 18.4319155313
MESH:D012220 Rhinitis Aspirin 4.3512372130
MESH:D012509 Sarcoma Doxorubicin 3.9715625365 17203757 16767912 18313854 15675481 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2314601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7817846226
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8918551238
MESH:D012640 Seizures Valproic Acid 5.891511512 11738929 14763951 15475178 3137016 17978042 11044598 16876388
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.2512269725
MESH:D012878 Skin Neoplasms Doxorubicin 9.4115692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.4116192470
MESH:D012878 Skin Neoplasms Tretinoin 9.4116467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5516767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9416709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5412833885
MESH:D013274 Stomach Neoplasms decitabine 2.5419037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.5417261132
MESH:D020521 Stroke Aspirin 4.3616403987
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Aspirin 9.1417672075
MESH:D013927 Thrombosis Ethinyl Estradiol 9.1415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 17.001399818 6582329 3712494 7505956 6587162
MESH:D013964 Thyroid Neoplasms decitabine 17.0017967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 17.0016010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 17.0016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7716051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.2317262798
MESH:D014376 Tuberculosis Tretinoin 3.2116040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.513119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.8916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.898074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.8917616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.8917653716
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.638888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3110091137
MESH:D014581 Urticaria Acetaminophen 8.8410982225
MESH:D014581 Urticaria Aspirin 8.8410982225 20485159
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.6114692618
MESH:D014594 Uterine Neoplasms Sulindac 9.6118645019
MESH:D014604 Uveal Neoplasms decitabine 12.8317785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.8316752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2117334414 17638931 17678736 16364871
MESH:D014820 Vitiligo Tretinoin 4.0416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D009396 Wilms Tumor Tretinoin 3.9516287080
Pathway ID Pathway Name
KEGG:00310 Lysine degradation
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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