AutismKB 2.0

Annotation Detail for FASTK


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Basic Information Top
Gene Symbol:FASTK ( FAST )
Gene Full Name: Fas-activated serine/threonine kinase
Band: 7q36.1
Quick LinksEntrez ID:10922; OMIM: 606965; Uniprot ID:FASTK_HUMAN; ENSEMBL ID: ENSG00000164896; HGNC ID: 24676
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FASTK mRNAaffects expression 21346803
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of FASTK mRNAdecreases expression 12419474
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of FASTK mRNAdecreases expression 15982314
D000082 Acetaminophen Acetaminophen affects the expression of FASTK mRNAaffects expression 17562736
C103303 alitretinoin alitretinoin results in decreased expression of FASTK mRNAdecreases expression 15982314
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of FASTK mRNAdecreases expression 15336504
12419474
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FASTK mRNAaffects cotreatment|increases expression 17942748
D015474 Isotretinoin Isotretinoin results in decreased expression of FASTK mRNAdecreases expression 15982314
C017947 sodium arsenite sodium arsenite results in decreased expression of FASTK mRNAdecreases expression 12760830
C004648 testosterone enanthate testosterone enanthate affects the expression of FASTK mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FASTK mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin metabolite results in decreased expression of FASTK mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of FASTK mRNAdecreases expression 15982314
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 9.2218769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2211752688 14514962 15322242
MESH:D000015 Abnormalities, Multiple Isotretinoin 5.0918769834
MESH:D017486 Acneiform Eruptions Isotretinoin 6.4616232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 12.5917505938
MESH:D000152 Acne Vulgaris Isotretinoin 12.5916185265 18769834
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0817306315 16712894
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1610965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3716456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.3116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms alitretinoin 1.9516344269
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9516873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.693084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.6916507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.691917145
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 7.8711237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.8718572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.8716051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 7.4310977129
MESH:D002386 Cataract Tretinoin 7.4317460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.996135515
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.9920056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9517110522 17681005 17333356 16105132 11677210 16919318 15861022
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9015668235 8697196 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.909407595
MESH:D003092 Colitis Tretinoin 3.8417035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.9618769834 9879862
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9615322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.969142499 17551590 9664655 10589399 14991402 16925845 9224671 9211117 9125849 8800419
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.2921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2919164858 11743745 10774834 11834606 14550746 16227642 19923254 19085960 12594235 12705907 12153990 16781746 2444490 14725611 12540782 15968718 16393943 16081117 11529661 19416960 17562736 19739265 19370779 11287661 16485898 11461765 11739529 17906064 10663392 18071297 11421492 14986274 17522070 16177239 12958197 18713872 15619225 10915739 12392966 16109766 19420014
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.5315322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.5318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.119664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.9215345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0920067830
MESH:D005355 Fibrosis Tretinoin 9.0917994277
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8316452187
MESH:D005909 Glioblastoma Tretinoin 3.0717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.729664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0312621046 15340226 16120746
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.9217440010
MESH:D006689 Hodgkin Disease sodium arsenite 3.2512676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.9216870215
MESH:D006930 Hyperalgesia Tretinoin 7.9216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8817937319
MESH:D007248 Infertility, Male sodium arsenite 6.8812646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.3015992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.7916144296
MESH:D007674 Kidney Diseases Acetaminophen 6.1615629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.1620008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0716705839
MESH:D007938 Leukemia Tretinoin 2.8217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8116482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0916294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.229834237 17649720 17712046 19225113 17368321 16891316 12679006 17107899 17506722 17339181 16140955 17301526 16766008 16788101 15748426 17361223 16331271 17294898 17217047 16935935 19642359 19035177 19029980 19075265 16823087
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.389224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3316248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6516611625 19460945 11587558 16610002 12587719 19014921 12969438 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.627678174
MESH:D008113 Liver Neoplasms sodium arsenite 7.6215276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.956135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9512151625
MESH:D008171 Lung Diseases sodium arsenite 3.2419095001
MESH:D008175 Lung Neoplasms alitretinoin 5.0316413115
MESH:D008175 Lung Neoplasms Isotretinoin 5.0315899809
MESH:D008175 Lung Neoplasms sodium arsenite 5.0319931552 17077188 15276417 17306315 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0319555203 11884234
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma Isotretinoin 5.3617237267
MESH:D008545 Melanoma sodium arsenite 5.3619082730 16487513
MESH:D008545 Melanoma Tretinoin 5.3616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1417596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0118551238 7678174
MESH:D009369 Neoplasms alitretinoin 8.7116946489
MESH:D009369 Neoplasms sodium arsenite 8.7111559025
MESH:D009369 Neoplasms Tretinoin 8.7116594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8020056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.9414600291
MESH:D009421 Nervous System Malformations Tretinoin 9.949125849
MESH:D009436 Neural Tube Defects sodium arsenite 7.5412854658
MESH:D009436 Neural Tube Defects Tretinoin 7.549142499
MESH:D009447 Neuroblastoma Isotretinoin 4.0917368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5316049721
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.9917306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9916936753
MESH:D010146 Pain Acetaminophen 6.8916870215
MESH:D010146 Pain Tretinoin 6.8916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.6811550810
MESH:D017499 Porokeratosis alitretinoin 6.1816144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 10.3718769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.3711118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2816039940
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011596 Psychomotor Disorders Isotretinoin 6.0718769834
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2216116481 16283617
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6118551238
MESH:D012878 Skin Neoplasms sodium arsenite 13.9719524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.978532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.9716192470
MESH:D012878 Skin Neoplasms Tretinoin 13.9716467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8812854658
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8916051514
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2216049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2211723127 17306315 16452187 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.7611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.7616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7816752155
MESH:D014652 Vascular Diseases sodium arsenite 4.5817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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