AutismKB 2.0

Annotation Detail for SUB1


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Basic Information Top
Gene Symbol:SUB1 ( MGC102747,P15,PC4,p14 )
Gene Full Name: SUB1 homolog (S. cerevisiae)
Band: 5p13.3
Quick LinksEntrez ID:10923; OMIM: 600503; Uniprot ID:TCP4_HUMAN; ENSEMBL ID: ENSG00000113387; HGNC ID: 19985
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SUB1 mRNAincreases expression 12958071
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SUB1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of SUB1 mRNAincreases expression 20458559
C099555 CD 437 CD 437 results in increased expression of SUB1 mRNAincreases expression 12958071
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of SUB1 mRNAaffects cotreatment|increases expression 16931933
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SUB1 mRNAincreases expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SUB1 mRNAdecreases expression 17557909
D016685 Mitomycin Mitomycin results in increased expression of SUB1 mRNAincreases expression 12760830
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of SUB1 mRNAincreases expression 17616710
D011794 Quercetin Quercetin results in increased expression of SUB1 mRNAincreases expression 15309432
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of SUB1 mRNAaffects cotreatment|increases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.049612607
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4111798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4114692618
MESH:D000743 Anemia, Hemolytic Quercetin 4.4117084956
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001260 Ataxia Telangiectasia Quercetin 5.2115336622
MESH:D001327 Autoimmune Diseases Quercetin 4.6219761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8416206674
MESH:D001943 Breast Neoplasms Quercetin 2.6418628248
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002105 Cadmium Poisoning Quercetin 5.8116962696
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.2916217749 15073043 14691202 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.2919519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1717234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D006332 Cardiomegaly Quercetin 3.4019794523
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017333356 17681005 17110522 16919318 15861022 11677210 16105132
MESH:D003110 Colonic Neoplasms Quercetin 2.4417148506 15741050 19056647 11134977 19440933 16640504 17191121
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6520501625
MESH:D015179 Colorectal Neoplasms Quercetin 2.6518095365 18852136
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8719496084
MESH:D004362 Drug Toxicity Lamivudine 9.2115040536
MESH:D004362 Drug Toxicity Zidovudine 9.2115040536
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.8512903497
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.8516704527 15547733 15547721 15878914 16510608 15150132 15264214 15623463 16805852
MESH:D005234 Fatty Liver arsenic trioxide 14.2415073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.2415345470
MESH:D005234 Fatty Liver Zidovudine 14.2418299183
MESH:D005355 Fibrosis Quercetin 4.1119474275
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005909 Glioblastoma Quercetin 3.5019804834
MESH:D005910 Glioma Quercetin 3.1117643826
MESH:D006402 Hematologic Diseases Zidovudine 4.9012579204
MESH:D006509 Hepatitis B Lamivudine 5.2717703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.2715274664 16476009 15309715 15631357 12044531
MESH:D015658 HIV Infections Lamivudine 7.339296927 11141242 20032539 17530837
MESH:D015658 HIV Infections Zidovudine 7.3317358032 11363243 11698656 11141242 20032539
MESH:D006943 Hyperglycemia Quercetin 4.1911834736 18262572
MESH:D006973 Hypertension Quercetin 2.9118356687
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007251 Influenza, Human Quercetin 4.7716624496
MESH:D007627 Keloid Quercetin 5.1717086741
MESH:D007674 Kidney Diseases Quercetin 3.1916962696
MESH:D007680 Kidney Neoplasms Zidovudine 3.9312579204
MESH:D007938 Leukemia arsenic trioxide 6.7415070760
MESH:D007938 Leukemia Quercetin 6.7417468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 10.4212560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 10.4220370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1620471514 19850784 17050201 16968895 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3216331271 19225113 19035177 12712474 15336539 17649720 17217047 19075265 16966277 17869043 12018890 11161223 16330433 17712046 11468182 16891316 15748426 17107899 16112521 15622746 9834237 12679006 19642359 16823087 15213294
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.1912741479
MESH:D008113 Liver Neoplasms arsenic trioxide 8.0114682389
MESH:D008113 Liver Neoplasms Mitomycin 8.0115113037
MESH:D008113 Liver Neoplasms Quercetin 8.0118980244
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.4920377131
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.4919519916
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.7011798837 19825857
MESH:D008175 Lung Neoplasms Quercetin 3.7016280456
MESH:D008175 Lung Neoplasms Zidovudine 3.7018800350
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.1017358032
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2215949261 19549372 19417148 11468182 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316882451 16105982
MESH:D009203 Myocardial Infarction Quercetin 3.0519595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.9219207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009369 Neoplasms Quercetin 2.8715185748
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2210525206
MESH:D020078 Neurogenic Inflammation Quercetin 4.5517929310
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4019495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.3512452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms CD 437 8.3517474084
MESH:D010051 Ovarian Neoplasms Quercetin 8.3519005980
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 9.1215580305
MESH:D010190 Pancreatic Neoplasms Mitomycin 9.1215113037
MESH:D010190 Pancreatic Neoplasms Quercetin 9.1216965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D011230 Precancerous Conditions Quercetin 4.1319056647
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3719131511
MESH:D011471 Prostatic Neoplasms Quercetin 3.3717292933 14715546
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D012206 Rhabdomyolysis Lamivudine 5.779296927
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.8116862918
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.6117007042
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.6112958204 17575124
MESH:D013274 Stomach Neoplasms Zidovudine 3.6117696246
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.8820435036 12845720 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms CD 437 8.8816720286
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.8816720314
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9712579204
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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