AutismKB 2.0

Annotation Detail for RALBP1


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Basic Information Top
Gene Symbol:RALBP1 ( RIP1,RLIP1,RLIP76 )
Gene Full Name: ralA binding protein 1
Band: 18p11.22
Quick LinksEntrez ID:10928; OMIM: 605801; Uniprot ID:RBP1_HUMAN; ENSEMBL ID: ENSG00000017797; HGNC ID: 9841
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05212Pancreatic cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by Rho GTPases
Pathway IDPathway Name
200165Regulation of RAC1 activity
200059Regulation of CDC42 activity
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1799Epilepsy
2066Lung cancer
2236Cardiovascular disease
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RALBP1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RALBP1 mRNAaffects expression 21346803
C480030 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid results in increased expression of RALBP1 proteinincreases expression 15930313
C027576 4-hydroxy-2-nonenal RALBP1 protein results in decreased susceptibility to 4-hydroxy-2-nonenaldecreases response to substance 15950949
D000255 Adenosine Triphosphate [[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicinaffects cotreatment|increases phosphorylation|increases transport 16087181
D000255 Adenosine Triphosphate Adenosine Triphosphate promotes the reaction [RALBP1 protein affects the transport of Leukotriene C4]affects transport|increases reaction 15386349
C088060 bisindolylmaleimide bisindolylmaleimide results in decreased phosphorylation of RALBP1 proteindecreases phosphorylation 16087181
D003078 Colchicine Colchicine inhibits the reaction [RALBP1 protein affects the transport of Leukotriene C4]affects transport|decreases reaction 15386349
D003078 Colchicine RALBP1 protein affects the transport of Colchicineaffects transport 15386349
D004317 Doxorubicin [[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicinaffects cotreatment|increases phosphorylation|increases transport 16087181
D004317 Doxorubicin PRKCA protein affects the reaction [RALBP1 protein affects the transport of and affects the susceptibility to Doxorubicin]affects reaction|affects response to substance|affects transport 16579994
D004317 Doxorubicin RALBP1 protein affects the export of Doxorubicinaffects export 15386349
D004317 Doxorubicin RALBP1 protein affects the transport of and affects the susceptibility to Doxorubicinaffects response to substance|affects transport 16579994
D004317 Doxorubicin RALBP1 protein affects the transport of Doxorubicinaffects transport 17273774
D004317 Doxorubicin RALBP1 protein modified form affects the susceptibility to Doxorubicinaffects response to substance 16087181
D004317 Doxorubicin RALBP1 protein results in decreased susceptibility to Doxorubicindecreases response to substance 15950949
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RALBP1 mRNAdecreases expression 15576828
D017997 Leukotriene C4 Adenosine Triphosphate promotes the reaction [RALBP1 protein affects the transport of Leukotriene C4]affects transport|increases reaction 15386349
D017997 Leukotriene C4 Colchicine inhibits the reaction [RALBP1 protein affects the transport of Leukotriene C4]affects transport|decreases reaction 15386349
D017997 Leukotriene C4 RALBP1 protein affects the transport of Leukotriene C4affects transport 15386349
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of RALBP1 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of RALBP1 mRNAdecreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of RALBP1 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of RALBP1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Doxorubicin 4.4717418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4714692618
MESH:D000419 Albuminuria Doxorubicin 4.6721441931
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1610965797
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001528 Behcet Syndrome Colchicine 6.2415870978
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8714601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.9117150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.6119526202 15994142 15136595 18382427 16096432 16322301 18628466 16826403 15939500 16264153 15668708 15993339 18234424 15634643 15692762 17369602 17983394 15567936 16595493 16935488 18695136 17426702 11325840 16115903
MESH:D016535 Bronchial Hyperreactivity Leukotriene C4 5.3512654629
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9816051944
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.7116234567 18059187 17876044 16023760
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2016201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.666189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.6017519947 15811867 15476868 16278810 17329180 16952015 16612575 18627295 17131338 15792986 16364871 17924179 16731534 17974986 17308081 17007740 16651473 17382496 16455267 17928571 16242529 16269455 15505089 16109756 17351982
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9817334414 16243910
MESH:D002386 Cataract Adenosine Triphosphate 4.6715003327
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.846135515
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9517110522 16105132 15861022 17333356 11677210 16919318 17681005
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 9.2717416283
MESH:D056486 Drug-Induced Liver Injury Selenium 9.2715131321
MESH:D004362 Drug Toxicity Doxorubicin 3.7518602426
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5217359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.3318037988
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.9215345470
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7419069698
MESH:D005909 Glioblastoma Doxorubicin 3.4217150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6015692506
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0416080930
MESH:D006331 Heart Diseases Doxorubicin 3.5618006777 16330681 16144979 16879835 12587719 17888722 16244371 16707910 16495754 14766674 18674790 16244372 17875725
MESH:D006333 Heart Failure Doxorubicin 7.4617481944
MESH:D006333 Heart Failure Selenium 7.4617162251
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0115692506
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D006689 Hodgkin Disease Doxorubicin 3.5015147373 18501091 17606976
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007251 Influenza, Human Selenium 11.5516624496
MESH:D007251 Influenza, Human Vitamin E 11.5516624496
MESH:D007674 Kidney Diseases Doxorubicin 6.4815369732 16775033 15699352
MESH:D007674 Kidney Diseases Vitamin E 6.4812488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 10.3516707910
MESH:D007676 Kidney Failure, Chronic Selenium 10.3516518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6716705839
MESH:D007859 Learning Disorders Colchicine 5.6411749816
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.3316085563
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.7016595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.7016169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.197678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.292876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.2917085340 16842330
MESH:D008171 Lung Diseases Vitamin E 3.2516863852
MESH:D008175 Lung Neoplasms Doxorubicin 2.6717418594 6189445
MESH:D008175 Lung Neoplasms Vitamin E 2.6711062179
MESH:D008223 Lymphoma Doxorubicin 3.5416098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7015621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.4215458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.4215318939
MESH:D008545 Melanoma Doxorubicin 2.3016827129
MESH:D008654 Mesothelioma Doxorubicin 6.4217638057
MESH:D008654 Mesothelioma Selenium 6.4215107826
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6115792986
MESH:D052016 Mucositis Doxorubicin 4.9417415656
MESH:D009203 Myocardial Infarction Doxorubicin 2.9915857846 19429709
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.8718551238 7678174
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9918259882
MESH:D009401 Nephrosis Doxorubicin 4.9116899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1016889571 15640375
MESH:D009447 Neuroblastoma Doxorubicin 3.3115555623
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D012516 Osteosarcoma Doxorubicin 4.2015930896
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.6811550810
MESH:D003557 Phyllodes Tumor Doxorubicin 5.3317983394
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.3317638057
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.3815897917 16868541 15749863 18437689 16888761 16729912
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3815084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D051437 Renal Insufficiency Doxorubicin 4.3617922066
MESH:D015427 Reperfusion Injury Leukotriene C4 4.7812967936
MESH:D012509 Sarcoma Doxorubicin 4.0915675481 15625365 18313854 16767912 17203757 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3716326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9417846226
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Doxorubicin 3.0015692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7017203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.4517909728 16010429
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5816049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.5817653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.3617638931 16364871 17678736 17334414
Pathway ID Pathway Name
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
REACT:11044 Signaling by Rho GTPases
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34199
    • No data
    Releated disease ID Related disease Name
    PA444065Epilepsy
    Releated drug ID Related drug Name
    PA449412doxorubicin
    PA448785carbamazepine
    PA450191lecithin
    PA450947phenytoin
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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