AutismKB 2.0

Annotation Detail for UGT2A1


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Basic Information Top
Gene Symbol:UGT2A1 ( - )
Gene Full Name: UDP glucuronosyltransferase 2 family, polypeptide A1
Band: 4q13.3
Quick LinksEntrez ID:10941; OMIM: 604716; Uniprot ID:UD2A1_HUMAN; ENSEMBL ID: ENSG00000173610; HGNC ID: 12542
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00140Steroid hormone biosynthesis
hsa00860Porphyrin and chlorophyll metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00040Pentose and glucuronate interconversions
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
hsa00053Ascorbate and aldarate metabolism
hsa00500Starch and sucrose metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C017229 1,2-dihydro-1,2-dihydroxy-5-methylchrysene UGT2A1 protein results in increased glucuronidation of 1,2-dihydro-1,2-dihydroxy-5-methylchryseneincreases glucuronidation 21164388
C032136 1-hydroxybenzo(a)pyrene UGT2A1 protein results in increased glucuronidation of 1-hydroxybenzo(a)pyreneincreases glucuronidation 21164388
C033146 1-hydroxypyrene UGT2A1 protein results in increased glucuronidation of 1-hydroxypyreneincreases glucuronidation 21164388
C029350 1-naphthol UGT2A1 protein results in increased glucuronidation of 1-naphtholincreases glucuronidation 21164388
C021338 3-hydroxybenzo(a)pyrene UGT2A1 protein results in increased glucuronidation of 3-hydroxybenzo(a)pyreneincreases glucuronidation 21164388
C489431 4-methylumbelliferone UGT2A1 protein results in increased glucuronidation of 4-methylumbelliferoneincreases glucuronidation 21164388
D000082 Acetaminophen Acetaminophen affects the expression of UGT2A1 mRNAaffects expression 17562736
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in increased expression of UGT2A1 mRNAincreases expression 16940010
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UGT2A1 mRNAaffects expression 16483693
C017228 benzo(a)pyrene 7,8-dihydrodiol UGT2A1 protein results in increased glucuronidation of benzo(a)pyrene 7,8-dihydrodiolincreases glucuronidation 21164388
D001564 Benzo(a)pyrene UGT2A1 protein results in increased glucuronidation of Benzo(a)pyrene analogincreases glucuronidation 21164388
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of UGT2A1 mRNAaffects cotreatment|affects expression 17602206
D003907 Dexamethasone Dexamethasone affects the expression of UGT2A1 mRNAaffects expression 15102944
C071371 dibenzo(a,l)pyrene 11,12-dihydrodiol UGT2A1 protein results in increased glucuronidation of dibenzo(a,l)pyrene 11,12-dihydrodiolincreases glucuronidation 21164388
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of UGT2A1 mRNAaffects cotreatment|affects expression 17602206
C099406 L 742694 L 742694 affects the expression of UGT2A1 mRNAaffects expression 15102944
D011084 Polycyclic Hydrocarbons, Aromatic UGT2A1 protein affects the susceptibility to Polycyclic Hydrocarbons, Aromaticaffects response to substance 21164388
C025299 polyphenols polyphenols results in decreased expression of UGT2A1 mRNAdecreases expression 16293270
C045950 propiconazole propiconazole results in increased expression of UGT2A1 mRNAincreases expression 19423681
C446685 systhane systhane results in increased expression of UGT2A1 mRNAincreases expression 19423681
C032910 triadimefon triadimefon results in increased expression of UGT2A1 mRNAincreases expression 19423681
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9620464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 6.426695378
MESH:D000236 Adenoma Diethylnitrosamine 6.4210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.7917162532 16434500 18056438 19052882 19061943 17620307
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9619183758
MESH:D001169 Arthritis, Experimental Dexamethasone 3.4717659584
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1120146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1117474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.803084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.8016807293 19519916 19394651 20512989 20007298 17761372 16779866 18665156 20524982 19208518 11831363 16681979 17428255 19539802 20935162 18788625 17138121 18393292 19335982 17055752 17173139 20101231 20084675 16698587 21159647 10672840 16288022 20432363 19822196 16502159 3581430 10737359 18506893 19052882 19171122 19418558 17978847 18056438 18785209 16830150 17162532 18494052 18978308 16878318 3084413 16540662 16569478 20727157 20514400 18691550 19383236 18971187 18210153 19919837 20214788 19107877 19701751 16935385 16328049
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0220419170
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.7817174075 21159647 2727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5919052882
MESH:D002972 Cleft Palate triadimefon 3.6816781842
MESH:D003110 Colonic Neoplasms Dexamethasone 4.0215824018
MESH:D003110 Colonic Neoplasms polyphenols 4.0216293270
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.1817728286
MESH:D019465 Craniofacial Abnormalities triadimefon 3.1816875885 15834900
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.3012438553
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1620387270
MESH:D003967 Diarrhea Dexamethasone 3.597237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.1011421492 2444490 15619225 19923254 15968718 12392966 16109766 16781746 19420014 19416960 19085960 11287661 14986274 10663392 16227642 11529661 16177239 16081117 17522070 16485898 12958197 11743745 10774834 19739265 11834606 18713872 10915739 17562736 17906064 19370779 12705907 14725611 14550746 19164858 12594235 12540782 18071297 12153990 16393943 11461765 11739529
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.1019107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.1019370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004485 Eczema Dexamethasone 4.3512438553
MESH:D004487 Edema Dexamethasone 3.3119703484
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0116302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9816530937
MESH:D005234 Fatty Liver Diethylnitrosamine 3.0920387270 21071580
MESH:D005756 Gastritis Acetaminophen 3.5716983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6020471113
MESH:D006529 Hepatomegaly propiconazole 14.3517178689 17178688
MESH:D006529 Hepatomegaly systhane 14.3517178688 17178689
MESH:D006529 Hepatomegaly triadimefon 14.3517178688 17178689
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.037520565
MESH:D006930 Hyperalgesia Acetaminophen 2.6116870215
MESH:D006973 Hypertension Dexamethasone 2.8917042910
MESH:D007249 Inflammation Dexamethasone 8.178960868 11099482
MESH:D007249 Inflammation Diethylnitrosamine 8.1718785209
MESH:D007249 Inflammation polyphenols 8.1716366677
MESH:D007569 Jaw Abnormalities triadimefon 4.8615834900 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.1412587719 15629191
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7618522880 19638242 18407596 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.2616718785
MESH:D008107 Liver Diseases Acetaminophen 12.2716610002 12969438 19014921 12587719 16611625 11587558 19460945 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 12.2717034775
MESH:D008107 Liver Diseases polyphenols 12.2716698588
MESH:D008107 Liver Diseases propiconazole 12.2719363144
MESH:D008107 Liver Diseases triadimefon 12.2719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1416871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.8521137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 13.8517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.852862719 21047994 19850985 19833225 19254457 19073162 10737359 9163691 19090486 19427195 19642983 12112319 20434301 20137499 15885732 19256749 20501860 21278145 19996281 19499222 15175105 16942905 20405173 19638242 19812893 12771043 20583210 20452335 21167192 19551842 2422723 21071580 18754104 18648771 18977376 20101389 20118626 18978307 18644402 19426721 19255062 19294768 20492335 19690152
MESH:D008113 Liver Neoplasms propiconazole 13.8519028983
MESH:D008113 Liver Neoplasms triadimefon 13.8519028983
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.7517942915 19009564 3124819 18544905 19126423 21159647 18093689 19004024 18164116 18079962 18253720 2563599 18775883 18308698 19539802 17174075 9362446 18282651 17854601 19519916 16267830 16842330
MESH:D008114 Liver Neoplasms, Experimental propiconazole 13.7517178689
MESH:D008114 Liver Neoplasms, Experimental systhane 13.7517178689
MESH:D008114 Liver Neoplasms, Experimental triadimefon 13.7517178689
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8517053015 20464547 20135361 18520028 20064080 18816296 6695378 18569708 20869020
MESH:D008175 Lung Neoplasms Dexamethasone 4.8515824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8520970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Polycyclic Hydrocarbons, Aromatic 4.8510814675
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1016381670
MESH:D009101 Multiple Myeloma Dexamethasone 3.4315744524 16118317 15867202
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.489809623
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.529029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1211141357
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.8820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0120387270
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3816540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.462563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4821297632
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0017292933
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.9111700416 18379247
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3210029692 19755658
MESH:D013272 Stomach Diseases Dexamethasone 4.2115472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.302093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3018456281
MESH:D013276 Stomach Ulcer Dexamethasone 3.3915138204
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.1517997062
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.287505956
MESH:D013964 Thyroid Neoplasms triadimefon 7.2817178689
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1417053015
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D014605 Uveitis Dexamethasone 4.711336536
Pathway ID Pathway Name
KEGG:00053 Ascorbate and aldarate metabolism
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00514 Other types of O-glycan biosynthesis
KEGG:00040 Pentose and glucuronate interconversions
KEGG:00860 Porphyrin and chlorophyll metabolism
KEGG:00830 Retinol metabolism
KEGG:00500 Starch and sucrose metabolism
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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