AutismKB 2.0

Annotation Detail for CBX1


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Basic Information Top
Gene Symbol:CBX1 ( CBX,HP1-BETA,HP1Hs-beta,HP1Hsbeta,M31,MOD1,p25beta )
Gene Full Name: chromobox homolog 1
Band: 17q21.32
Quick LinksEntrez ID:10951; OMIM: 604511; Uniprot ID:CBX1_HUMAN; ENSEMBL ID: ENSG00000108468; HGNC ID: 1551
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of CBX1 mRNAdecreases expression 16514628
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in decreased expression of CBX1 mRNAdecreases expression 16940010
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of CBX1 mRNAaffects cotreatment|increases expression 19684285
D004958 Estradiol Estradiol results in decreased expression of CBX1 mRNAdecreases expression 15757668
D004958 Estradiol Estradiol results in increased expression of CBX1 mRNAincreases expression 16514628
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CBX1 mRNAdecreases expression 17475347
D005472 Fluorouracil CBX1 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C070081 fulvestrant fulvestrant results in decreased expression of CBX1 mRNAdecreases expression 16514628
C006253 pirinixic acid pirinixic acid results in decreased expression of CBX1 mRNAdecreases expression 18445702
D020849 Raloxifene Raloxifene results in decreased expression of CBX1 mRNAdecreases expression 16514628
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of CBX1 mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CBX1 mRNAincreases expression 19684285
D014212 Tretinoin Tretinoin results in decreased expression of CBX1 proteindecreases expression 16569592
D014212 Tretinoin EHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to POU5F1 promoter]]affects binding|increases reaction 16415856
D014212 Tretinoin EHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to ZFP42 promoter]]affects binding|increases reaction 16415856
D014212 Tretinoin Tretinoin promotes the reaction [[HIST3H3 protein modified form binds to CBX1 protein] which binds to POU5F1 promoter]affects binding|increases reaction 16415856
D014212 Tretinoin Tretinoin promotes the reaction [[HIST3H3 protein modified form binds to CBX1 protein] which binds to ZFP42 promoter]affects binding|increases reaction 16415856
C025643 vinclozolin vinclozolin results in decreased expression of CBX1 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Estradiol 7.2111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2114692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.2117638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000419 Albuminuria Raloxifene 4.7217451421 17308373
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000544 Alzheimer Disease Raloxifene 2.5615800139
MESH:D000740 Anemia Fluorouracil 9.0317963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.0311748828
MESH:D001008 Anxiety Disorders vinclozolin 3.7319015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3716456186
MESH:D001284 Atrophy fulvestrant 4.9711514358
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.9319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.9312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.9316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001930 Brain Injuries Raloxifene 4.6116580743
MESH:D001943 Breast Neoplasms Estradiol 3.0112948864 17261762 17289903 16675129 17018787 14630087 19861407 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 3.0116595493 16110121 18608205 18357371 19217205 16557594 15136595
MESH:D001943 Breast Neoplasms fulvestrant 3.0118984771
MESH:D001943 Breast Neoplasms Raloxifene 3.0117440819 17242785 15775269 15572757 17049068 17893378 17261762 16912660 16837676 15758505 17595753 17952589
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0120435547
MESH:D001943 Breast Neoplasms Tretinoin 3.0116873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8416051944
MESH:D002277 Carcinoma Fluorouracil 8.4817121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7116924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7118930000 16332177 17088986 16799960 17971768 17045692
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.711917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0618695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8218986760 16757204 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8216096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5215775269
MESH:D002386 Cataract Tretinoin 3.1517460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8418566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0117333356 16919318 11677210 16105132 17110522 17681005 15861022
MESH:D002779 Cholestasis pirinixic acid 8.0119176532
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9012621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.909407595
MESH:D003072 Cognition Disorders Raloxifene 4.7615800139
MESH:D003092 Colitis Tretinoin 3.8417035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2517287894 17725105 17016597 16510598 17018589 15001691 17169374 16340194 18772588 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017695437 17401013 16391804 14970324 16282729 18802399 18448328 18509181 18949393 15148649 18288408 16331619 17594712 20501625 15289873 18383874 17016601 17454858 16303861 16524972 17094418 17255274
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4817551590 9125849 10589399 9224671 16925845 8800419 14991402 9142499 9211117 9664655
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D007644 Darier Disease Fluorouracil 4.9516733453
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2617474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.3419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.3415920148 17451421 17308373
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema pirinixic acid 12.0812083418
MESH:D004487 Edema Raloxifene 12.0815860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.5318230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.5318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.5412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.5415845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 12.9819148513
MESH:D016889 Endometrial Neoplasms Estradiol 12.9819148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 12.9816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4716481741 16337965 17638652 16785472 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.1116938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.7615345470
MESH:D005234 Fatty Liver pirinixic acid 13.7620131406 19236843
MESH:D005234 Fatty Liver Raloxifene 13.7617473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0920067830
MESH:D005355 Fibrosis Tretinoin 9.0917994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D005909 Glioblastoma Tretinoin 3.0717312396
MESH:D005910 Glioma Fluorouracil 2.9116145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.0318337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.0316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.729664655 14991402
MESH:D006331 Heart Diseases Raloxifene 3.6111110106
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.3016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Raloxifene 5.3515787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.7317937319
MESH:D007248 Infertility, Male fulvestrant 11.7311514358
MESH:D007248 Infertility, Male vinclozolin 11.7316467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.4316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.4316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.3015992940 17551590
MESH:D007674 Kidney Diseases Estradiol 2.6415618244
MESH:D007680 Kidney Neoplasms Estradiol 7.7915610895
MESH:D007680 Kidney Neoplasms Fluorouracil 7.7916985049
MESH:D007889 Leiomyoma Raloxifene 4.6116973256
MESH:D007938 Leukemia Tretinoin 2.8217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8116932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0919850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2219075265 17712046 19642359 17368321 17339181 16766008 17649720 9834237 17294898 16331271 17107899 16140955 16823087 17217047 16788101 15748426 19035177 17361223 17506722 19225113 16891316 19029980 16935935 12679006 17301526
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.389224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0216248980 18397230
MESH:D008113 Liver Neoplasms Fluorouracil 7.5915113037 17045692 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 7.5916377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1712151625
MESH:D008175 Lung Neoplasms Fluorouracil 2.3715246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3711884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9515086387
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6217203775 11807958 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7315863610
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7118986760 16757204
MESH:D009101 Multiple Myeloma Raloxifene 3.5116497877
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D009232 Myxoma Raloxifene 5.7316343187
MESH:D009369 Neoplasms Fluorouracil 8.5518600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 8.5517405874
MESH:D009369 Neoplasms Tretinoin 8.5516946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009421 Nervous System Malformations Estradiol 17.1011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.1014600291
MESH:D009421 Nervous System Malformations Tretinoin 17.109125849
MESH:D009436 Neural Tube Defects Tretinoin 3.129142499
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5116436463
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010024 Osteoporosis Raloxifene 3.4617882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3415579764 17893378 15758505 17823083
MESH:D010051 Ovarian Neoplasms Estradiol 4.9119401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9116936753
MESH:D010146 Pain Tretinoin 2.9916870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.4616500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4615976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.0111399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.0118042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17199135
MESH:D011471 Prostatic Neoplasms Estradiol 2.6016740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6018626508 19082440
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6016220300 15731164 16536755
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D011693 Purpura Raloxifene 5.7315770314
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1115538739 18286688 16160472 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2216116481 16283617
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D012878 Skin Neoplasms Tretinoin 5.7216467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5317498489 19084572 16424979 19015929 17522103 17172411 18567086 16951190 18396642 15786421
MESH:D013274 Stomach Neoplasms Tretinoin 2.5317261132
MESH:D020521 Stroke Raloxifene 3.9116837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1117045167 16026305
MESH:D013978 Tibial Fractures Estradiol 14.3019048282
MESH:D013978 Tibial Fractures Raloxifene 14.3019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 10.1816280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.1816051514
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8517572228
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.8016803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.8016129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.3816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7316343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26126
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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