AutismKB 2.0

Annotation Detail for PDIA5


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Basic Information Top
Gene Symbol:PDIA5 ( FLJ30401,PDIR )
Gene Full Name: protein disulfide isomerase family A, member 5
Band: 3q21.1
Quick LinksEntrez ID:10954; OMIM: NA; Uniprot ID:PDIA5_HUMAN; ENSEMBL ID: ENSG00000065485; HGNC ID: 24811
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Diabetes pathways
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PDIA5 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PDIA5 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PDIA5 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PDIA5 mRNAdecreases expression 15003993
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDIA5 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDIA5 mRNAaffects cotreatment|affects expression 17602206
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PDIA5 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of PDIA5 mRNAdecreases expression 15375163
C517826 tetrabrominated diphenyl ether 47 tetrabrominated diphenyl ether 47 results in increased expression of PDIA5 mRNAincreases expression 20056577
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PDIA5 mRNAdecreases expression 18495758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PDIA5 mRNAincreases expression 16267337
D014635 Valproic Acid Valproic Acid results in increased expression of PDIA5 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 15.717525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 15.7115322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 15.718875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000236 Adenoma Diethylnitrosamine 2.946695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 18.7317162532 18056438 16434500 19052882 19061943 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.7316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.7316835633
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001321 Autistic Disorder Acetaminophen 2.3218445737
MESH:D001321 Autistic Disorder tetrabrominated diphenyl ether 47 2.3219211157
MESH:D001321 Autistic Disorder Valproic Acid 2.3218396377 16609825 17688650 18558336 19460635 15238991 17157402 18985861 19232924 18775368 17507914 20603192 18940202 18316065 18177632
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.3715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.378888407
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9517474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.653084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6520512989 19919837 16502159 19539802 17162532 18210153 20524982 19052882 20101231 20935162 19383236 16807293 18056438 20727157 19107877 19171122 19208518 17173139 18978308 17055752 18691550 18785209 21159647 18506893 16779866 3084413 16698587 17761372 20432363 20214788 16830150 17428255 19822196 20084675 19335982 16935385 3581430 10672840 18971187 18393292 18494052 16878318 16540662 18788625 16681979 17978847 18665156 19394651 16328049 11831363 10737359 17138121 16569478 19701751 19418558 20514400 20007298 19519916 16288022
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18670907 18850075
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.7414694615
MESH:D002386 Cataract Acetaminophen 7.7410977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.977505956 17174075 21159647 2727394
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.8419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.8416835633
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.168697196 15340226 12621046 16354765 15668235
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.7015095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.7014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5216575769 17688650 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3417107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.8821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.8821346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.8811743745 18071297 15968718 11461765 16393943 10663392 19164858 16109766 19923254 16781746 10774834 14725611 12153990 10915739 18713872 19085960 12540782 11421492 17562736 11529661 16485898 17522070 2444490 11287661 12392966 12705907 15619225 16081117 12594235 12958197 19420014 14986274 19370779 16177239 11739529 16227642 11834606 14550746 17906064 19739265 19416960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.8819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.8820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.8819641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1716714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.3717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Diethylnitrosamine 14.1420387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 14.1419236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 14.1414986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly pirinixic acid 8.9919772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.9916120746 15340226 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3118606429 16959395 8697196 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007249 Inflammation Diethylnitrosamine 5.1718785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1712878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1216705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9119638242 18665156 18407596 20032147 18522880
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1812878042
MESH:D008107 Liver Diseases Acetaminophen 4.0319460945 11587558 12969438 12587719 19784758 16611625 19014921 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0317034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms Clofibric Acid 11.1817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.1819499222 19551842 20405173 20501860 12112319 21047994 20137499 19642983 19256749 18978307 19638242 19833225 18754104 19996281 20492335 20118626 18644402 18648771 20452335 20583210 21278145 2862719 19812893 19255062 19426721 19254457 19690152 19073162 12771043 18977376 19294768 2422723 9163691 19090486 10737359 19427195 15175105 20434301 21071580 19850985 21167192 15885732 20101389 16942905
MESH:D008113 Liver Neoplasms pirinixic acid 11.1820007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1816984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.103124819 18775883 2563599 16267830 19126423 18544905 21159647 18079962 17174075 19009564 18093689 19539802 18164116 17942915 18253720 19519916 19004024 16842330 9362446 18282651 17854601 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1012151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.3021163286 20512841 20970405 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3019555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008881 Migraine Disorders Valproic Acid 3.3118765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.623581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.238888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.6720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6712819281 16049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.6714694615
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4716540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.702563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2711399792 11896295 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.2720603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.8112752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures Valproic Acid 6.3214763951 17978042 11044598 1511512 3137016 16876388 11738929 15475178
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.838532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8316192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.117505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3416049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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