AutismKB 2.0

Annotation Detail for IFI44L


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Basic Information Top
Gene Symbol:IFI44L ( C1orf29 )
Gene Full Name: interferon-induced protein 44-like
Band: 1p31.1
Quick LinksEntrez ID:10964; OMIM: NA; Uniprot ID:IF44L_HUMAN; ENSEMBL ID: ENSG00000137959; HGNC ID: 17817
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IFI44L mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of IFI44L mRNAincreases expression 19619570
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of IFI44L mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of IFI44L mRNAaffects cotreatment|increases expression 17404688
D013629 Tamoxifen Tamoxifen results in increased expression of IFI44L mRNAincreases expression 19155303
C004648 testosterone enanthate testosterone enanthate affects the expression of IFI44L mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IFI44L mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IFI44L mRNAdecreases expression 19619570
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI44L mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 14514962 11752688
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.249612607
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.8617868700
MESH:D001930 Brain Injuries Progesterone 4.6815665606 15845082 15380490
MESH:D001943 Breast Neoplasms Estradiol 1.9717289903 16675129 12948864 14630087 19861407 17261762 18497071 17018787
MESH:D001943 Breast Neoplasms Progesterone 1.9717614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 1.9719155303 16273361 19103187 19059307 20135344 21138602 19221464 19289846 19115204 19288272 19189210 20065188 15668708 19487384 19011961 20005174 19142967 17049068 19084267 19200415 19189212 18984771 18855134 17440819 17893378 21152245 16202921 17242785 18815881 17261762 11161223 19244106 20544844 16818667 18351453 20859285 15565566 16873071 18629630 19066611 18425577 18821012 18997820 20390343 19410462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1016924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9818566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2112621046 15340226 15668235 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.8119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.8119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.9117187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 9.0111462148
MESH:D004362 Drug Toxicity Zidovudine 9.0115040536
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 10.4617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.4619031437
MESH:D016889 Endometrial Neoplasms Estradiol 8.0418566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.0419155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Progesterone 9.9616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.9610568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Tamoxifen 9.1919224547 14986274
MESH:D005234 Fatty Liver Zidovudine 9.1918299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006402 Hematologic Diseases Zidovudine 5.0612579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D015658 HIV Infections Zidovudine 3.6311698656 11141242 20032539 17358032 11363243
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.2717440010
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16354765 15340226 18606429 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8215869954
MESH:D007249 Inflammation Progesterone 9.1615869954
MESH:D007249 Inflammation Tamoxifen 9.1619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.1612878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.1616393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Estradiol 2.7415618244
MESH:D007680 Kidney Neoplasms Estradiol 14.1215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 14.1218625569
MESH:D007680 Kidney Neoplasms Zidovudine 14.1212579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.7420370541
MESH:D008064 Lipidoses Tamoxifen 3.3715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5912878042
MESH:D008113 Liver Neoplasms Tamoxifen 4.7216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008175 Lung Neoplasms Tamoxifen 3.6218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6211884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 3.6218800350
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.1011408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 11.1017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 11.1016827153 11731420 19196722 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 14.4519453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.4519453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.3617358032
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5216810080
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009421 Nervous System Malformations Estradiol 10.7711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.7714600291
MESH:D010051 Ovarian Neoplasms Estradiol 5.1419401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.1416525653 17393432
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1016740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1015067354
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9418045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013088 Spermatocele Tamoxifen 4.8116709447
MESH:D013119 Spinal Cord Injuries Progesterone 12.4616503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 12.4619457130
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.458653321 17572228 16712894
MESH:D014625 Vaginal Neoplasms Zidovudine 5.1812579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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