AutismKB 2.0

Annotation Detail for C10orf116


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Basic Information Top
Gene Symbol:C10orf116 ( APM2 )
Gene Full Name: chromosome 10 open reading frame 116
Band: 10q23.2
Quick LinksEntrez ID:10974; OMIM: NA; Uniprot ID:APM2_HUMAN; ENSEMBL ID: ENSG00000148671; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of C10ORF116 mRNAincreases expression 20382639
C095105 bexarotene bexarotene results in increased expression of C10ORF116 mRNAincreases expression 17178900
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of C10ORF116 mRNAaffects cotreatment|decreases expression 17404688
D005472 Fluorouracil Fluorouracil results in increased expression of C10ORF116 mRNAincreases expression 17039268
D008727 Methotrexate C10ORF116 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D015735 Mifepristone Mifepristone results in decreased expression of C10ORF116 mRNAdecreases expression 17584828
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of C10ORF116 mRNAaffects cotreatment|decreases expression 17404688
C009277 sodium arsenate sodium arsenate results in decreased expression of C10ORF116 mRNAdecreases expression 12727804
C017947 sodium arsenite sodium arsenite results in decreased expression of C10ORF116 mRNAdecreases expression 12727804
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of C10ORF116 mRNAdecreases expression 16704738
D014212 Tretinoin Tretinoin results in increased expression of C10ORF116 mRNAincreases expression 16249480
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 9.2512039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2514514962 11752688 15322242
MESH:D000230 Adenocarcinoma Estradiol 4.5511473722
MESH:D000230 Adenocarcinoma Fluorouracil 4.5517638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1217306315 16712894
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000740 Anemia Fluorouracil 9.1217963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.1211748828
MESH:D001169 Arthritis, Experimental Tretinoin 3.1616412693
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.9717286800
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.9716292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.4116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5617868700
MESH:D001930 Brain Injuries Progesterone 4.4315665606 15845082 15380490
MESH:D001943 Breast Neoplasms bexarotene 3.8516818667 16344269
MESH:D001943 Breast Neoplasms Estradiol 3.8516675129 14630087 12948864 17018787 17289903 19861407 18497071 17261762
MESH:D001943 Breast Neoplasms Fluorouracil 3.8519217205 18357371 15136595 16595493 18608205 16110121 16557594
MESH:D001943 Breast Neoplasms Methotrexate 3.8516978400
MESH:D001943 Breast Neoplasms Progesterone 3.8515562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.8520435547
MESH:D001943 Breast Neoplasms Tretinoin 3.8516166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8916051944
MESH:D002277 Carcinoma Fluorouracil 8.5617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.5616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.7617088986 16799960 17971768 17045692 18930000 16332177
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.7615276417 16507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.761917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2716247446
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0718695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.7917066447 16757204 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.7918572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.7916051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 16120746 18850075
MESH:D002386 Cataract Tretinoin 3.1717460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.7620889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.7618566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.7619524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9412621046 16354765 15668235 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 5.949407595
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2518772588 16340194 17287894 16510598 17016597 17725105 17172411 15001691 17018589 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017016601 18802399 18288408 18509181 15289873 16524972 16391804 17454858 18949393 20501625 18448328 17695437 16282729 16331619 15148649 16303861 17594712 17255274 14970324 17094418 18383874 17401013
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Methotrexate 5.599562676 12039119
MESH:D019465 Craniofacial Abnormalities sodium arsenate 5.5910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.5910048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.5914991402 10589399 9224671 17551590 9664655 9211117 8800419 16925845 9125849 9142499
MESH:D003550 Cystic Fibrosis Methotrexate 4.3719747007
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D003882 Dermatomyositis Methotrexate 5.2920191521
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6717187935
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 4.2018186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.2020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.6815322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.6818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9417692515
MESH:D016889 Endometrial Neoplasms Estradiol 7.7119148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.7116569247
MESH:D004715 Endometriosis Mifepristone 16.1216134523
MESH:D004715 Endometriosis Progesterone 16.1216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 16.129294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6220426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6217638652 16337965 16785472 16481741 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1811564622
MESH:D005124 Eye Abnormalities Tretinoin 9.1816938888 9664655
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005355 Fibrosis Tretinoin 9.2117994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D005910 Glioma Fluorouracil 2.9216145905
MESH:D018149 Glucose Intolerance sodium arsenate 5.2319446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.3216518429
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.1018337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.1016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.7614991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.3216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5815869954
MESH:D007248 Infertility, Male sodium arsenite 3.0815346721 12646999
MESH:D007249 Inflammation Progesterone 5.2015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2012878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.0516627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.4016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.4015992940 17551590
MESH:D007674 Kidney Diseases Estradiol 6.3615618244
MESH:D007674 Kidney Diseases sodium arsenite 6.3620008137
MESH:D007680 Kidney Neoplasms Estradiol 7.8815610895
MESH:D007680 Kidney Neoplasms Fluorouracil 7.8816985049
MESH:D007805 Language Development Disorders Methotrexate 5.259562676
MESH:D007938 Leukemia Tretinoin 2.8317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8416932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2416935935 17712046 16823087 16140955 19035177 9834237 17107899 16766008 19225113 17368321 17339181 12679006 17294898 15748426 19029980 17506722 16788101 17217047 16891316 16331271 19075265 17649720 19642359 17361223 17301526
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008103 Liver Cirrhosis Methotrexate 3.7714986274
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5218397230 16248980
MESH:D008113 Liver Neoplasms Fluorouracil 7.7217045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms sodium arsenite 7.7215276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008171 Lung Diseases sodium arsenite 3.2619095001
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.2418516814
MESH:D008175 Lung Neoplasms bexarotene 5.0017849452
MESH:D008175 Lung Neoplasms Fluorouracil 5.0015246190
MESH:D008175 Lung Neoplasms sodium arsenite 5.0016712894 17306315 15276417 17077188 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0019555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D008223 Lymphoma Methotrexate 4.0517352296
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.3211161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 10.5919196723 19196722 15591091
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.5911408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.5917203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma sodium arsenite 3.4119082730 16487513
MESH:D008545 Melanoma Tretinoin 3.4116752155
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7416757204 18986760
MESH:D052016 Mucositis Methotrexate 5.4717488658
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 5.0018186108
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009369 Neoplasms Fluorouracil 8.7018239605 18600527 16928823
MESH:D009369 Neoplasms sodium arsenite 8.7011559025
MESH:D009369 Neoplasms Tretinoin 8.7016946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 5.0019196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009421 Nervous System Malformations Estradiol 17.3116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.3114600291
MESH:D009421 Nervous System Malformations Tretinoin 17.319125849
MESH:D009436 Neural Tube Defects sodium arsenate 12.7918186108 10525206 11749123 19446573
MESH:D009436 Neural Tube Defects sodium arsenite 12.7912854658
MESH:D009436 Neural Tube Defects Tretinoin 12.799142499
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D010051 Ovarian Neoplasms Estradiol 15.4219401270
MESH:D010051 Ovarian Neoplasms Mifepristone 15.4216525653
MESH:D010051 Ovarian Neoplasms Progesterone 15.4217393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 15.4217306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 15.4216936753
MESH:D010146 Pain Tretinoin 3.0216870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.4919003803 15113037 16500647 16929163
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4915976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5618626508 19082440
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5616039940
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011565 Psoriasis Methotrexate 3.4717410198
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1416160472 18286688 18722050 15538739
MESH:D051437 Renal Insufficiency Methotrexate 4.8917352296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9018045962
MESH:D012878 Skin Neoplasms sodium arsenite 9.7918572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7916192470
MESH:D012878 Skin Neoplasms Tretinoin 9.7916467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.4716503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5417498489 18396642 16424979 17172411 15786421 16951190 17522103 19084572 18567086 19015929
MESH:D013274 Stomach Neoplasms Tretinoin 2.5417261132
MESH:D013576 Syndactyly Methotrexate 5.209562676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 10.2716280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.2716051514
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5511723127 16712894 16452187 17306315
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 16.6516803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 16.6511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 16.6516129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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