AutismKB 2.0

Annotation Detail for CLP1


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Basic Information Top
Gene Symbol:CLP1 ( HEAB,hClp1 )
Gene Full Name: CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)
Band: 11q12.1
Quick LinksEntrez ID:10978; OMIM: 608757; Uniprot ID:CLP1_HUMAN; ENSEMBL ID: ENSG00000172409; HGNC ID: 16999
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Post-Elongation Processing of the Transcript
Transcription
mRNA Processing
Gene Expression
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CLP1 mRNAdecreases expression 18648102
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CLP1 mRNAincreases expression 20382639
D002392 Catechin Catechin results in decreased expression of CLP1 mRNAdecreases expression 15465739
D002995 Clofibric Acid Clofibric Acid affects the expression of CLP1 mRNAaffects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CLP1 mRNAaffects expression 17555576
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CLP1 mRNAaffects binding|increases activity|increases expression 19710929
C025462 sulindac sulfide sulindac sulfide results in decreased expression of CLP1 mRNAdecreases expression 12734198
D013629 Tamoxifen Tamoxifen affects the expression of CLP1 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000544 Alzheimer Disease sulindac sulfide 3.1318759972
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1819066611 11161223 16818667 19084267 19244106 20544844 19142967 19011961 19487384 15565566 18425577 15668708 19410462 18629630 16873071 19155303 18984771 16202921 18351453 20135344 18997820 21152245 19059307 17893378 17242785 18815881 17440819 19189210 19289846 20390343 19103187 19115204 18855134 19288272 20005174 17261762 18821012 19221464 20065188 20859285 16273361 19189212 21138602 19200415 17049068
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.077296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.0716924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.5112391285
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.187505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1820889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.4119486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 14.4117110522 16105132 15861022 17681005 17333356 11677210 16919318
MESH:D002779 Cholestasis pirinixic acid 14.4119176532
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1018759878 12868966 14531868 2524372 8156756 11298694 8970840 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6919279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.018291058 9328219 9022650 1440618 16192314 6482804 7440962 18289764 6679447 18692083 18648102 9653073 11289319
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.9012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.9019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1920544844 16202921 17893378 19155303
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.563581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5620426865
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.5015345470
MESH:D005234 Fatty Liver pirinixic acid 14.5020131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 14.5014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 18467677 19772884 19176532
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D020138 Hyperhomocysteinemia Catechin 5.1917292331
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Tamoxifen 2.4619457130
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.066582329
MESH:D007680 Kidney Neoplasms Tamoxifen 8.0618625569
MESH:D008064 Lipidoses Tamoxifen 3.3215342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.339327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3818564211
MESH:D008113 Liver Neoplasms Clofibric Acid 7.9317602206
MESH:D008113 Liver Neoplasms pirinixic acid 7.9315890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 7.9316684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.676587162 598648 3712494 1399818
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7614580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9219453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.973581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819200415 19189210 19196722
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D013088 Spermatocele Ethinyl Estradiol 12.8516709447
MESH:D013088 Spermatocele Tamoxifen 12.8516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.063712494 6582329 1399818 6587162 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.308074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.308653321 17572228 16712894
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.6414692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 10.6418645019
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
KEGG:03015 mRNA surveillance pathway
REACT:78 Post-Elongation Processing of the Transcript
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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