AutismKB 2.0

Annotation Detail for MAPRE2


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Basic Information Top
Gene Symbol:MAPRE2 ( EB1,EB2,RP1 )
Gene Full Name: microtubule-associated protein, RP/EB family, member 2
Band: 18q12.1-q12.2
Quick LinksEntrez ID:10982; OMIM: 605789; Uniprot ID:MARE2_HUMAN; ENSEMBL ID: ENSG00000166974; HGNC ID: 6891
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1993Esophagus cancer
2051Leukemia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of MAPRE2 mRNAincreases expression 19031421
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MAPRE2 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of MAPRE2 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MAPRE2 mRNAdecreases expression 20064835
D016572 Cyclosporine Cyclosporine results in decreased expression of MAPRE2 mRNAdecreases expression 20106945
D007052 Ibuprofen Ibuprofen affects the expression of MAPRE2 mRNAaffects expression 17070997
C030667 methylazoxymethanol methylazoxymethanol results in increased expression of MAPRE2 mRNAincreases expression 17107856
C008493 methylselenic acid methylselenic acid results in increased expression of MAPRE2 mRNAincreases expression 18548127
D015741 Metribolone Metribolone results in decreased expression of MAPRE2 mRNAdecreases expression 17010675
C006253 pirinixic acid pirinixic acid results in decreased expression of MAPRE2 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of MAPRE2 mRNAincreases expression 17426115
C116926 rofecoxib rofecoxib results in decreased expression of MAPRE2 mRNAdecreases expression 17070997
D013750 Tetrachloroethylene Tetrachloroethylene results in increased expression of MAPRE2 mRNAincreases expression 19031421
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Ibuprofen 4.566375363
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.7920127859 20464547
MESH:D000230 Adenocarcinoma Ibuprofen 4.7910697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.803712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.806695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000544 Alzheimer Disease Ibuprofen 3.1918351690
MESH:D000707 Anaphylaxis Ibuprofen 5.389532969
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001169 Arthritis, Experimental rofecoxib 4.4116690336
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1911289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D002545 Brain Ischemia Ibuprofen 5.0415837124
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.6720146248 17474063
MESH:D001943 Breast Neoplasms Tetrachloroethylene 2.6715986119
MESH:D002100 Cachexia Ibuprofen 5.6215141370
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.863581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.863084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.827505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8212371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.8619486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.8619486331
MESH:D002779 Cholestasis pirinixic acid 13.8619176532
MESH:D003110 Colonic Neoplasms rofecoxib 3.3212902858
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9411298694 8156756 8970840 18759878 14531868 12868966 2524372 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.612952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.8118289764 6482804 18692083 6679447 9022650 8291058 1440618 18648102 11289319 16192314 7440962 9328219 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8111743745 18071297 12153990 12958197 14550746 11287661 11739529 16109766 12540782 11461765 16227642 16781746 19420014 16177239 12594235 10915739 10774834 12705907 2444490 11421492 19370779 19739265 17562736 17522070 11529661 17906064 19923254 15968718 15619225 19085960 16485898 16081117 19164858 14986274 11834606 19416960 12392966 14725611 16393943 18713872 10663392
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.7716133044 18446180 18450898
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004715 Endometriosis Ibuprofen 10.2615652904
MESH:D004715 Endometriosis rofecoxib 10.2615652904
MESH:D019446 Endotoxemia Ibuprofen 5.1211545620
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.453581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4516530937
MESH:D005234 Fatty Liver Cyclosporine 7.9319224547
MESH:D005234 Fatty Liver pirinixic acid 7.9319236843 20131406
MESH:D005334 Fever Ibuprofen 4.6816997862
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D005355 Fibrosis Cyclosporine 3.2812639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006529 Hepatomegaly pirinixic acid 3.1316221962 18467677 19772884 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D006984 Hypertrophy Ibuprofen 5.0816672835
MESH:D007235 Infant, Premature, Diseases Ibuprofen 6.0116133044
MESH:D007249 Inflammation Ibuprofen 3.493291741
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007410 Intestinal Diseases rofecoxib 5.1715831440
MESH:D007417 Intestinal Polyps rofecoxib 5.4911245490
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.199022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9915629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.9918776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.586582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5812371664
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.269327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.8415474484
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 2.8417565644
MESH:D008107 Liver Diseases Acetaminophen 4.5816611625 19460945 16610002 19014921 12587719 12969438 11587558 19784758
MESH:D008107 Liver Diseases Tetrachloroethylene 4.5817267091
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.4921137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.4915890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.73598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 6.737955063
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5620464547 20869020 6695378 17053015 18816296 18520028 20135361 20064080 18569708
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 3.7710697514
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.513581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.7011141357
MESH:D009369 Neoplasms pirinixic acid 8.7017405874
MESH:D009369 Neoplasms Tetrachloroethylene 8.7011911487
MESH:D009395 Nephritis, Interstitial Ibuprofen 5.166375363
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009410 Nerve Degeneration Ibuprofen 4.4710961664
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.526482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010003 Osteoarthritis Ibuprofen 8.517009135
MESH:D010003 Osteoarthritis rofecoxib 8.5116690336
MESH:D010146 Pain Acetaminophen 7.2716870215
MESH:D010146 Pain Ibuprofen 7.273291741
MESH:D010149 Pain, Postoperative Ibuprofen 12.3316678543
MESH:D010149 Pain, Postoperative rofecoxib 12.3318165598 16678543
MESH:D010190 Pancreatic Neoplasms Ibuprofen 3.5212384795
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7417292933
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.7417409433
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.7416205645
MESH:D011507 Proteinuria Ibuprofen 4.746375363
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4110029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.971399818 6582329 3712494 6587162 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.108074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1017053015
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.3419057314
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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