AutismKB 2.0

Annotation Detail for CCNI


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Basic Information Top
Gene Symbol:CCNI ( CYC1,CYI )
Gene Full Name: cyclin I
Band: 4q21.1
Quick LinksEntrez ID:10983; OMIM: NA; Uniprot ID:CCNI_HUMAN; ENSEMBL ID: ENSG00000118816; HGNC ID: 1595
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2106Pancreas cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of CCNI mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CCNI mRNAdecreases expression 20018196
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in increased expression of CCNI mRNA]affects reaction|increases expression 17585979
D016572 Cyclosporine Cyclosporine results in increased expression of CCNI mRNAincreases expression 20106945
D004391 Dust Dust results in decreased expression of CCNI mRNAdecreases expression 17805423
D004958 Estradiol Estradiol affects the expression of CCNI mRNAaffects expression 15598610
C071834 glycidamide glycidamide results in increased expression of CCNI mRNAincreases expression 17822822
D037742 Nanotubes, Carbon Nanotubes, Carbon results in increased expression of CCNI mRNAincreases expression 15585362
D011374 Progesterone Progesterone affects the expression of CCNI mRNAaffects expression 17251523
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CCNI mRNAdecreases expression 18796159
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 14514962 15322242
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001778 Blood Coagulation Disorders Clofibrate 9.8619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215845082 15380490 15665606
MESH:D001943 Breast Neoplasms Estradiol 1.8416675129 14630087 12948864 19861407 17289903 17018787 18497071 17261762
MESH:D001943 Breast Neoplasms Progesterone 1.8417614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7816924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.2020889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 17.201399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.2012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.2018566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Cyclosporine 3.0619486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 12621046 8697196 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D050171 Dyslipidemias Clofibrate 4.2116707586
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.0217692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.1118566989 19148513 11473722
MESH:D004715 Endometriosis Progesterone 9.5816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.5810568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Clofibrate 8.6519224547
MESH:D005234 Fatty Liver Cyclosporine 8.6519224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Cyclosporine 9.3612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3620067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1512621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 16959395 8697196 18606429 16354765
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007249 Inflammation Progesterone 5.3015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3012200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.0916393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.308314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 6.3015618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.8515610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4811807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.4817203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4416810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 10.2711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.2714600291
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 5.209802331
MESH:D010051 Ovarian Neoplasms Estradiol 5.0519401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.0517393432 16525653
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0516740699
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.5615862959 16503802
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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