AutismKB 2.0

Annotation Detail for GCN1L1


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Basic Information Top
Gene Symbol:GCN1L1 ( GCN1,GCN1L,KIAA0219,PRIC295 )
Gene Full Name: GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
Band: 12q24.2
Quick LinksEntrez ID:10985; OMIM: 605614; Uniprot ID:GCN1L_HUMAN; ENSEMBL ID: ENSG00000089154; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic affects the expression of GCN1L1 mRNAaffects expression 18414638
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GCN1L1 mRNAaffects expression 17484886
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D018246 Adrenocortical Adenoma Arsenic 6.2817306315
MESH:D020261 Arsenic Poisoning Arsenic 2.9716835338 12569548 18414634 16251483
MESH:D050197 Atherosclerosis Arsenic 3.5119371607 12928151
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.5415721981 16050911 15673190 3786805 15700767 10355542 16227642 18705752 16097048 16124888 16192424 16011737
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.8315504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.3517306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.3518788625
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7918922899 15504454 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.5818640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.7719152805 17938729 15738583
MESH:D002340 Carotid Artery Diseases Arsenic 4.7818022660 16973168
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.1416177239 7120509 19336974 10092053 19085960 7179309 11566570 3786805 16227642 15998439 7440962 3732212 21278145 6884620 15968718 15027814 9327722 6623471 4309450 2869522 17522070 10915739
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.7261145 12795759 19224547 12631006 16239168 15959796 16045604 17595544
MESH:D005355 Fibrosis Carbon Tetrachloride 4.2218705752
MESH:D005534 Foot Diseases Arsenic 6.636392382
MESH:D006505 Hepatitis Carbon Tetrachloride 4.2719110552 19900420
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.4216899240
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.9617050553
MESH:D006973 Hypertension Arsenic 3.0116076760 11953799 9931084
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.8515338365
MESH:D006987 Hypesthesia Arsenic 6.6316093927
MESH:D007642 Keratosis Arsenic 5.8816930632 12749816
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.8517339181
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0411408273 16943688 21278145 17174718 17334410 16221502 16239168 17157831 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7612741479 18006644 17721639 18412020 18279442 18210741 10355542 15673190 17557913 16097048 18205269 15925388 16027843 12666154 12546737 17708605 12898905 17761835 15996030 18395914 12586293 15931870 12632514 18054572 18429990 18472332 15893842 17805973 18418968 16638106 16011737 17714472 17565644 17823541 18395095 18277467 17631135 17869086 12632512 18376398 16192424 17922224 18705752 15370692 15057751 14716496 16116963 12389079 18317297 12649538 17944888 17481882 12609069 16015684 17525996 18472094 15362042 16136751 18187930 17698563 18339082 14512876 12667390 14748882 17976157 18251166 18481824 15052691 18420326 12445418 14716833 14620537 17766677 16248980 15959796 15818738 15123356 15730626 18263696 15338365 20821823 18156304 17900296 13678700 11481614 12445421 16033810 18166357 17640975 15876570 12958196 14724832 15650968
MESH:D008107 Liver Diseases Arsenic 4.5511134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.5515830285 16246199 15720792 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.9315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.2014706259 16899240
MESH:D008113 Liver Neoplasms Arsenic 5.2416368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 5.2419294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8912014681 15583823
MESH:D008175 Lung Neoplasms Arsenic 2.2117306315 19168569 17976673
MESH:D017202 Myocardial Ischemia Arsenic 4.3915371236
MESH:D009436 Neural Tube Defects Arsenic 3.7516620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.9817056641
MESH:D010051 Ovarian Neoplasms Arsenic 2.8617306315
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.8516093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.886392382 15371236 16905509
MESH:D011471 Prostatic Neoplasms Arsenic 3.5416140617
MESH:D011507 Proteinuria Arsenic 4.6121343184
MESH:D012871 Skin Diseases Arsenic 2.8417050553 19834688 16353154 17548696 17938729 18709164 6392382 16702368 16759981 15952646 17453740
MESH:D012878 Skin Neoplasms Arsenic 3.1916251483 15504454 17050553 19538983 17976673 17029826
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.9619429237 15987713 18640142 11144890 17306315 17976673 19322015
MESH:D014652 Vascular Diseases Arsenic 5.6217056641
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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