AutismKB 2.0

Annotation Detail for METAP2


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Basic Information Top
Gene Symbol:METAP2 ( MAP2,MNPEP,p67,p67eIF2 )
Gene Full Name: methionyl aminopeptidase 2
Band: 12q22
Quick LinksEntrez ID:10988; OMIM: 601870; Uniprot ID:AMPM2_HUMAN; ENSEMBL ID: ENSG00000111142; HGNC ID: 16672
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2053Colon cancer
2090Hamman-Rich syndrome
2237Neoplasm metastasis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of METAP2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of METAP2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of METAP2 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of METAP2 mRNAdecreases expression 17942131
D000499 Allylamine Allylamine affects the expression of METAP2 mRNAaffects expression 15910882
D000643 Ammonium Chloride Ammonium Chloride affects the expression of METAP2 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of METAP2 mRNAdecreases expression 17942131
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of METAP2 mRNAincreases expression 20382639
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of METAP2 mRNAdecreases expression 17942131
C032036 bromobenzene bromobenzene results in increased expression of METAP2 mRNAincreases expression 12628495
D016572 Cyclosporine Cyclosporine results in decreased expression of METAP2 mRNAdecreases expression 17942131
D004317 Doxorubicin Doxorubicin results in decreased expression of METAP2 mRNAdecreases expression 16404146
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of METAP2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of METAP2 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of METAP2 mRNAincreases expression 18035473
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of METAP2 mRNA]affects reaction|decreases expression 15016801
C071834 glycidamide glycidamide results in increased expression of METAP2 mRNAincreases expression 17822822
D011374 Progesterone Progesterone results in decreased expression of METAP2 mRNAdecreases expression 18070364
D012643 Selenium Selenium results in decreased expression of METAP2 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of METAP2 mRNAaffects cotreatment|increases expression 17942748
D014501 Uranium Uranium affects the expression of METAP2 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of METAP2 mRNAaffects expression 15672453
D014810 Vitamin E Vitamin E results in decreased expression of METAP2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7411752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8417505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.9520127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 9.9517418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.9514692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.9517638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.596695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2716835633
MESH:D000419 Albuminuria Doxorubicin 4.4421441931
MESH:D000740 Anemia Fluorouracil 8.3517963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.3511748828
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9619183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5914601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2317868700
MESH:D001930 Brain Injuries Progesterone 4.1515665606 15380490 15845082
MESH:D001932 Brain Neoplasms Doxorubicin 3.7117150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3020146248 17474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.3015567936 18628466 15993339 15939500 15668708 16264153 15994142 15136595 16322301 19526202 16115903 18695136 17426702 16096432 18234424 17983394 16595493 17369602 18382427 16826403 15692762 16935488 15634643 11325840
MESH:D001943 Breast Neoplasms Fluorouracil 2.3015136595 18608205 19217205 16595493 16110121 16557594 18357371
MESH:D001943 Breast Neoplasms Progesterone 2.3015562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3020435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8216050911
MESH:D002276 Carcinoid Tumor Doxorubicin 12.0016051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.0016051944
MESH:D002277 Carcinoma Fluorouracil 7.8917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.6816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.6816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.683084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.6816023760 18059187 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.6817045692 17088986 18930000 16332177 17971768 16799960
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.5016201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.5018695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.3920419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.396189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.3916757204 16280240 17066447 18986760
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3116120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.4616612575 17308081 17924179 17351982 17382496 17329180 15811867 17131338 17928571 18627295 16269455 16651473 17974986 17519947 16109756 16364871 16242529 15476868 16278810 16731534 16455267 17007740 15505089 15792986 16952015
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9116243910 17334414
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.706135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.7020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.7012371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis Cyclosporine 7.5019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5016105132 17681005 16919318 17110522 17333356 11677210 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0615668235 16354765 15340226 12621046 8697196
MESH:D003092 Colitis Selenium 3.6717936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2215001691 18772588 17725105 17169374 16510598 17018589 17287894 17016597 17172411 16340194
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6218259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6214970324 17454858 17094418 16303861 17594712 17695437 17016601 16331619 18448328 20501625 17255274 15148649 18949393 18802399 18288408 16524972 15289873 18383874 17401013 18509181 16391804 16282729
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4510048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.4519769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.5318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.5318551238
MESH:D007644 Darier Disease Fluorouracil 4.6816733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.3817187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 18.2021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 18.2018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.2019370779 18071297 11461765 17522070 10663392 12705907 11743745 19164858 15619225 16227642 19923254 12958197 11529661 16177239 10774834 11421492 12392966 11287661 16485898 11834606 19416960 19085960 12153990 14986274 14725611 10915739 17562736 19420014 18713872 16081117 14550746 15968718 12594235 17906064 16393943 16109766 16781746 19739265 11739529 12540782 2444490
MESH:D056486 Drug-Induced Liver Injury bromobenzene 18.2012628495 10092053
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 18.2017416283
MESH:D056486 Drug-Induced Liver Injury Selenium 18.2015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.2020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004362 Drug Toxicity Doxorubicin 7.8418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8411462148
MESH:C538011 Eales disease Vitamin E 4.609068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8015322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.6812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.6817692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.3817359293
MESH:D004715 Endometriosis Progesterone 8.6016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.6010568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0518037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.0615173087 16481741 16337965 16785472 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005234 Fatty Liver Cyclosporine 7.2419224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.2415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4819069698
MESH:D005355 Fibrosis Cyclosporine 8.1212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1220067830
MESH:D005756 Gastritis Acetaminophen 3.5716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D005909 Glioblastoma Doxorubicin 3.2817150277
MESH:D005910 Glioma Fluorouracil 2.8316145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.6715692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.6718337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.7711294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 10.7716080930
MESH:D006331 Heart Diseases Doxorubicin 3.4116330681 18674790 16879835 17888722 16244372 16144979 16495754 16244371 14766674 16707910 17875725 18006777 12587719
MESH:D006333 Heart Failure Doxorubicin 7.0217481944
MESH:D006333 Heart Failure Selenium 7.0217162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8015692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7815340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6616490937 16863852
MESH:D006689 Hodgkin Disease Doxorubicin 3.3117606976 18501091 15147373
MESH:D019584 Hot Flashes Vitamin E 3.8714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9415340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6116870215
MESH:D006973 Hypertension Cyclosporine 4.8110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8118850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7016569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2915869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4117937319
MESH:D007249 Inflammation Flavonoids 8.0117296493
MESH:D007249 Inflammation Progesterone 8.0115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.0112200463 12878042
MESH:D007251 Influenza, Human Selenium 10.6116624496
MESH:D007251 Influenza, Human Vitamin E 10.6116624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007674 Kidney Diseases Acetaminophen 13.9215629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 13.928314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 13.9215369732 15699352 16775033
MESH:D007674 Kidney Diseases Vitamin E 13.9212488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.6416707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.6416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.0016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.0016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 17.0012371664
MESH:D007680 Kidney Neoplasms Fluorouracil 17.0016985049
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0516085563
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.4416439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4412878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4416169303
MESH:D008107 Liver Diseases Acetaminophen 1.6011587558 12969438 19460945 19784758 16610002 16611625 19014921 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.357678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.3521137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 10.3517045692 16603448 18383874 15113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.3516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.442876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.4416842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.4412151625
MESH:D008171 Lung Diseases Vitamin E 3.1016863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.4517053015 20464547 18816296 18569708 6695378 20869020 20064080 20135361 18520028
MESH:D008175 Lung Neoplasms Doxorubicin 6.456189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 6.4515246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4511884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 6.4511062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6815086387
MESH:D008223 Lymphoma Doxorubicin 3.3816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7017654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4615621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.6415458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.6411408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.6415318939
MESH:D008545 Melanoma Doxorubicin 2.2716827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008654 Mesothelioma Doxorubicin 6.1517638057
MESH:D008654 Mesothelioma Selenium 6.1515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4015792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.2516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.2518986760 16757204
MESH:D052016 Mucositis Doxorubicin 4.6817415656
MESH:D009203 Myocardial Infarction Doxorubicin 2.9019429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.9818551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.9818551238 7678174
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9118259882
MESH:D009369 Neoplasms Benzo(a)pyrene 4.8911141357
MESH:D009369 Neoplasms Fluorouracil 4.8918600527 18239605 16928823
MESH:D009401 Nephrosis Doxorubicin 4.6616899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.9819348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.9816889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1114600291
MESH:D009447 Neuroblastoma Doxorubicin 3.2115555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7818514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3616436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.5612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.5616049721
MESH:D012516 Osteosarcoma Doxorubicin 4.0215930896
MESH:D010051 Ovarian Neoplasms Progesterone 2.4917393432 16525653
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6316500647 16929163 19003803 15113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5811578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0517983394
MESH:D010954 Plasmacytoma Selenium 4.7815087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0517638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1312371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0811896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1117292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1115749863 18437689 16868541 15897917 16729912 16888761
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1119082440 18626508
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1115084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.2016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9218722050 16160472 18286688 15538739
MESH:D051437 Renal Insufficiency Doxorubicin 4.1117922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8218045962
MESH:D012509 Sarcoma Doxorubicin 3.8915625365 17203757 16767912 18313854 17710206 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.1314601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6817846226
MESH:D012640 Seizures 2,4-dinitrotoluene 5.6218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.6218551238
MESH:D012871 Skin Diseases Vitamin E 2.4118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.1319755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 9.1315692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1316192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4615625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8416709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.1716503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.392093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.3918396642 15786421 18567086 16951190 16424979 17498489 17522103 19084572 19015929 17172411
MESH:D020521 Stroke Vitamin E 3.4316517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.2917909728 16010429
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8916280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.5716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.5716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.5717053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.5717653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.6310091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.6310091137
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.7816803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1914692618
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1117638931 17334414 17678736 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00134 - L-Methionine Dietary supplement;Micronutrient;Essential Amino Acids
DB02310 - 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium
DB02640 ligand Fumagillin Anti-Bacterial Agents;Antiprotozoal Agents;Angiogenesis Inhibitors
DB02893 - D-Methionine
DB03086 - N'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)Hydrazide
DB03396 - (E)-(2r,3r,4s,5r)-3,4,5-Trihydroxy-2-Methoxy-8,8-Dimethyl-Non-6-Enoic Acid ((3s,6r)-6-Hydroxy-2-Oxo-Azepan-3-Yl)-Amide
DB03900 - 2-Methyl-2-Propanol
DB04108 - (2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide
DB04324 - Ovalicin
DB07309 - 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID
DB07313 - 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID
DB07322 - 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID
DB07323 - 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID
DB07377 - N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE
DB07746 - 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID
DB08633 - (CHLOROACETYL)CARBAMIC ACID (3R,4S,5S,5R)-5-METHOXY-4-[(2R,3R)-2-METHYL-3-(3-METHYL-2-BUTENYL)OXIRANYL]-1-OXASPIRO[2.5]OCT-6-YL ESTER
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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