Gene Symbol:	SLC27A4 ( ACSVL4,FATP4,IPS )
Gene Full Name:	solute carrier family 27 (fatty acid transporter), member 4
Band:	9q34.11
Quick Links	Entrez ID:10999; OMIM: 604194; Uniprot ID:S27A4_HUMAN; ENSEMBL ID: ENSG00000167114; HGNC ID: 10998
Relate to Another Database:	SFARIGene; denovo-db

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C016403	2,4-dinitrotoluene	2,4-dinitrotoluene affects the expression of SLC27A4 mRNA	affects expression	21346803
C035207	4-amino-2,6-dinitrotoluene	4-amino-2,6-dinitrotoluene affects the expression of SLC27A4 mRNA	affects expression	21346803
D001104	Arbutin	Arbutin results in decreased expression of SLC27A4 mRNA	decreases expression	17103032
D004281	Docosahexaenoic Acids	PPARA protein promotes the reaction [Docosahexaenoic Acids results in increased expression of SLC27A4 mRNA]	increases expression\|increases reaction	18489776
D015118	Eicosapentaenoic Acid	PPARA protein promotes the reaction [Eicosapentaenoic Acid results in increased expression of SLC27A4 mRNA]	increases expression\|increases reaction	18489776
D019301	Oleic Acid	PPARA protein promotes the reaction [Oleic Acid results in increased expression of SLC27A4 mRNA]	increases expression\|increases reaction	18489776
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SLC27A4 mRNA	increases expression	18467677
C023036	perfluorooctanoic acid	PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of SLC27A4 mRNA]	increases expression\|increases reaction	18467677
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SLC27A4 mRNA	affects binding\|increases activity\|increases expression	18489776
C006253	pirinixic acid	pirinixic acid results in increased expression of SLC27A4 mRNA	increases expression	20059764 18467677 15375163 18301758
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of SLC27A4 mRNA]	increases expression\|increases reaction	18467677 20059764

Disease ID	Disease Name	Direct Evidence	Inference Chemical Name	Inference Score	Publication
MESH:D000014	Abnormalities, Drug-Induced		4-amino-2,6-dinitrotoluene	4.28	7525203
MESH:D055371	Acute Lung Injury		pirinixic acid	3.38	18653653
MESH:D018248	Adenoma, Liver Cell		pirinixic acid	3.82	16434500
MESH:D000860	Anoxia		Oleic Acid	6.23	15090967
MESH:D001321	Autistic Disorder		Docosahexaenoic Acids	3.18	18582451
MESH:D001778	Blood Coagulation Disorders		pirinixic acid	3.39	19483382
MESH:D006528	Carcinoma, Hepatocellular		2,4-dinitrotoluene	1.78	16705839
MESH:D002386	Cataract		4-amino-2,6-dinitrotoluene	3.76	14694615
MESH:D002779	Cholestasis		pirinixic acid	3.00	19176532
MESH:D000013	Congenital Abnormalities		4-amino-2,6-dinitrotoluene	4.37	15095906
MESH:D003490	Cyanosis		2,4-dinitrotoluene	4.32	18551238
MESH:D003550	Cystic Fibrosis		Docosahexaenoic Acids	4.90	19747007
MESH:D003876	Dermatitis, Atopic		pirinixic acid	2.52	18249437
MESH:D056486	Drug-Induced Liver Injury		2,4-dinitrotoluene	4.30	18551238 21346803
MESH:D056486	Drug-Induced Liver Injury		4-amino-2,6-dinitrotoluene	4.30	21346803
MESH:D004487	Edema		perfluorooctanoic acid	7.79	12083418 17259670
MESH:D004487	Edema		pirinixic acid	7.79	12083418
MESH:D005234	Fatty Liver		pirinixic acid	3.01	19236843 20131406
MESH:D006333	Heart Failure		pirinixic acid	2.67	20558911
MESH:D006529	Hepatomegaly		perfluorooctanoic acid	9.74	3609246
MESH:D006529	Hepatomegaly		pirinixic acid	9.74	19772884 18467677 16221962 19176532
MESH:D006930	Hyperalgesia		perfluorooctanoic acid	4.04	12083418
MESH:D006943	Hyperglycemia		pirinixic acid	3.41	20558911
MESH:C536271	Ichthyosis prematurity syndrome	marker/mechanism
MESH:D007249	Inflammation		perfluorooctanoic acid	3.17	12083418
MESH:D007333	Insulin Resistance		pirinixic acid	2.78	16306350
MESH:D007680	Kidney Neoplasms		2,4-dinitrotoluene	3.17	16705839
MESH:D015459	Leukemia-Lymphoma, Adult T-Cell		Docosahexaenoic Acids	5.24	17077332
MESH:D007984	Leydig Cell Tumor		perfluorooctanoic acid	5.57	8812269
MESH:D008106	Liver Cirrhosis, Experimental		pirinixic acid	1.35	15474484
MESH:D008107	Liver Diseases		Docosahexaenoic Acids	3.45	17056761
MESH:D008113	Liver Neoplasms		perfluorooctanoic acid	4.95	14757943 18709148
MESH:D008113	Liver Neoplasms		pirinixic acid	4.95	16377806 15890375 20007298
MESH:D055370	Lung Injury		Oleic Acid	5.65	15090967
MESH:D009135	Muscular Diseases		pirinixic acid	3.81	16239165
MESH:D009203	Myocardial Infarction		pirinixic acid	2.22	19151258
MESH:D015428	Myocardial Reperfusion Injury		pirinixic acid	3.13	16411023
MESH:D009336	Necrosis		2,4-dinitrotoluene	4.20	18551238
MESH:D009369	Neoplasms		pirinixic acid	2.05	17405874
MESH:D052556	Niemann-Pick Disease, Type C		perfluorooctanoic acid	5.26	9802331
MESH:D009765	Obesity		pirinixic acid	1.86	20558911
MESH:D009784	Occupational Diseases		2,4-dinitrotoluene	9.90	12819281 16049721
MESH:D009784	Occupational Diseases		4-amino-2,6-dinitrotoluene	9.90	14694615
MESH:D011297	Prenatal Exposure Delayed Effects		perfluorooctanoic acid	4.73	17132714
MESH:D011654	Pulmonary Edema		Oleic Acid	6.18	15090967
MESH:D015427	Reperfusion Injury		pirinixic acid	2.49	19058328
MESH:D012128	Respiratory Distress Syndrome, Adult		Oleic Acid	5.61	18549715
MESH:D012640	Seizures		2,4-dinitrotoluene	2.68	18551238
MESH:D013274	Stomach Neoplasms		Docosahexaenoic Acids	3.07	19015929
MESH:D001749	Urinary Bladder Neoplasms		2,4-dinitrotoluene	2.36	16049721
MESH:D014571	Urologic Neoplasms		2,4-dinitrotoluene	4.65	10091137

Pathway ID	Pathway Name
KEGG:04975	Fat digestion and absorption
KEGG:03320	PPAR signaling pathway
REACT:15518	Transmembrane transport of small molecules

AutismKB 2.0

Annotation Detail for SLC27A4

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics