AutismKB 2.0

Annotation Detail for KIF2C


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:KIF2C ( KNSL6,MCAK )
Gene Full Name: kinesin family member 2C
Band: 1p34.1
Quick LinksEntrez ID:11004; OMIM: 604538; Uniprot ID:KIF2C_HUMAN; ENSEMBL ID: ENSG00000142945; HGNC ID: 6393
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Pathway IDPathway Name
200010Aurora B signaling
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1843Metastasis to lymph nodes
1841Stomach cancer
2053Colon cancer
1823Infertility, Male
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of KIF2C mRNAincreases expression 19031421
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of KIF2C mRNAincreases expression 20713471
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of KIF2C mRNAdecreases expression 12958071
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of KIF2C proteinaffects expression 20106945
D001374 Azacitidine [Azacitidine co-treated with Thalidomide] affects the expression of KIF2C mRNAaffects cotreatment|affects expression 18720364
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of KIF2C mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of KIF2C mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KIF2C mRNAdecreases expression 19150397
20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of KIF2C mRNAincreases expression 15003993
D002104 Cadmium Cadmium results in increased expression of KIF2C mRNAincreases expression 19031421
C099555 CD 437 CD 437 results in decreased expression of KIF2C mRNAdecreases expression 12958071
D016572 Cyclosporine Cyclosporine results in decreased expression of KIF2C mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of KIF2C mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of KIF2C mRNA]decreases reaction|increases expression 17854601
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KIF2C mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of KIF2C mRNAaffects expression 17351261
D005031 Ethylenethiourea Ethylenethiourea results in decreased expression of KIF2C mRNAdecreases expression 18801409
D005031 Ethylenethiourea Ethylenethiourea results in increased expression of KIF2C mRNAincreases expression 18801409
D005472 Fluorouracil KIF2C protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D019833 Genistein Genistein affects the expression of KIF2C mRNAaffects expression 18847459
D007529 Isoflavones Isoflavones results in decreased expression of KIF2C mRNAdecreases expression 17374662
D008713 Methimazole Methimazole results in decreased expression of KIF2C mRNAdecreases expression 17403546
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of KIF2C mRNAincreases expression 20713471
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in decreased expression of KIF2C mRNAdecreases expression 12832660
D009532 Nickel Nickel results in increased expression of KIF2C mRNAincreases expression 19031421
C494474 perchlorate perchlorate results in decreased expression of KIF2C mRNAdecreases expression 17403546
18801409
D011441 Propylthiouracil Propylthiouracil results in decreased expression of KIF2C mRNAdecreases expression 17403546
C017947 sodium arsenite sodium arsenite results in decreased expression of KIF2C mRNAdecreases expression 17998272
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KIF2C mRNAaffects cotreatment|increases expression 17942748
D013750 Tetrachloroethylene Tetrachloroethylene results in increased expression of KIF2C mRNAincreases expression 19031421
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of KIF2C mRNAincreases expression 19031421
D013792 Thalidomide [Azacitidine co-treated with Thalidomide] affects the expression of KIF2C mRNAaffects cotreatment|affects expression 18720364
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of KIF2C mRNAdecreases expression 17951470
D014212 Tretinoin Tretinoin results in decreased expression of KIF2C mRNAdecreases expression 16249480
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7814514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 7.788333272
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D055371 Acute Lung Injury Nickel 4.3316166738
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.7720127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.7714692618
MESH:D000230 Adenocarcinoma Ethylenethiourea 12.777955072
MESH:D000230 Adenocarcinoma Fluorouracil 12.7717638652
MESH:D000230 Adenocarcinoma Genistein 12.7711473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.296695378
MESH:D000236 Adenoma Diethylnitrosamine 10.2910737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 10.2910545420 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.1216434500 19061943 18056438 19052882 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.1216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6217306315 16712894
MESH:D000505 Alopecia Isoflavones 8.8517569567
MESH:D000505 Alopecia Tretinoin 8.8515955085
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 4.1816510725
MESH:D000740 Anemia Fluorouracil 7.8815504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.8811748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8019183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.3815885639
MESH:D001169 Arthritis, Experimental Thalidomide 11.389598899
MESH:D001169 Arthritis, Experimental Tretinoin 11.3816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2016292516
MESH:D001249 Asthma Tretinoin 2.2616456186
MESH:D050197 Atherosclerosis Cadmium 6.5515687053
MESH:D050197 Atherosclerosis Methylcholanthrene 6.5511922910
MESH:D001471 Barrett Esophagus Tretinoin 4.1416935849
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 13.9719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.9712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.9716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 6.7011921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.7017474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.7017474063
MESH:D001943 Breast Neoplasms Fluorouracil 6.7019217205 16595493 15136595 18608205 16557594 16110121 18357371
MESH:D001943 Breast Neoplasms Genistein 6.7016873071 16541309 17200150
MESH:D001943 Breast Neoplasms Methylcholanthrene 6.7017474063
MESH:D001943 Breast Neoplasms Nickel 6.7015986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.7020435547
MESH:D001943 Breast Neoplasms Tetrachloroethylene 6.7015986119
MESH:D001943 Breast Neoplasms Tretinoin 6.7016873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3116813970
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3816051944
MESH:D002277 Carcinoma Fluorouracil 12.7217121937
MESH:D002277 Carcinoma Methylcholanthrene 12.7210545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 12.7216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8716168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.3421507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.3410737359 16328049 11831363 16878318 16698587 18788625 17162532 20727157 19107877 16288022 19383236 10672840 18494052 3084413 16830150 20214788 18691550 19701751 20935162 17173139 16807293 18393292 18056438 18506893 20432363 16502159 16681979 17055752 18785209 20514400 17428255 17978847 20512989 18210153 19418558 17138121 16540662 16569478 19394651 19171122 20101231 19052882 18971187 19208518 20084675 17761372 20524982 19919837 18665156 16935385 19519916 19539802 18978308 21159647 19335982 3581430 20007298 19822196 16779866
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.3416332177 16799960 17045692 18930000 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.3416924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.3415276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 13.3416313753
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.341917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.4320419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 13.4316757204 16280240 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.4318572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 13.4318922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.4316096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 7.1316332659
MESH:D002318 Cardiovascular Diseases Isoflavones 7.1317689850
MESH:D002386 Cataract Tretinoin 2.9317460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 23.8920889678
MESH:D002471 Cell Transformation, Neoplastic Cadmium 23.8917332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 23.8912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 23.8917174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 23.8916192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 23.8919524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3116129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.8519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.8516835633
MESH:D018281 Cholangiocarcinoma Thalidomide 14.8518291259
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.9212912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 12.3618590720 15913567 7624871 19486331 12927374 18164287 16629650 15500046
MESH:D002779 Cholestasis Cyclosporine 12.3619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3617681005 11677210 16105132 17110522 16919318 15861022 17333356
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.5710220858 19407337
MESH:D002822 Choriocarcinoma Tretinoin 4.8716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3716354765 15340226 15668235 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.379407595
MESH:D003092 Colitis Thalidomide 8.9816680017
MESH:D003092 Colitis Tretinoin 8.9817035595
MESH:D003110 Colonic Neoplasms Fluorouracil 3.6717016597 15001691 16340194 16510598 17287894 17725105 17172411 17169374 18772588 17018589
MESH:D003110 Colonic Neoplasms Genistein 3.6717182828
MESH:D015179 Colorectal Neoplasms Azacitidine 3.5419934284
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5417016601 17401013 17255274 16524972 17594712 18802399 18949393 16303861 18288408 15148649 18448328 20501625 16391804 16282729 15289873 18509181 17094418 16331619 14970324 18383874 17695437 17454858
MESH:D015179 Colorectal Neoplasms Isoflavones 3.5417116718
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8314669216 17141729
MESH:D016510 Corneal Neovascularization Thalidomide 5.309301478
MESH:D003389 Cranial Nerve Diseases Thalidomide 6.029200351
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Thalidomide 3.729200351
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.729125849 10589399 14991402 17551590 9224671 16925845 9211117 9142499 9664655 8800419
MESH:D003424 Crohn Disease Thalidomide 4.0316078585
MESH:D007644 Darier Disease Fluorouracil 4.5116733453
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.6917244072 17100760 19470301
MESH:D003877 Dermatitis, Contact Nickel 4.382952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.6720387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.6716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.6717107852
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 5.8318289764 20133375 17522070 7624871
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.8319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.8320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1411000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 6.148113982 16716910 8273558 15177302 9599246 11698051 7812673
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.0015322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.0018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9212538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.3116402032
MESH:D016889 Endometrial Neoplasms Ethylenethiourea 11.667955072
MESH:D016889 Endometrial Neoplasms Genistein 11.6611473722
MESH:D016889 Endometrial Neoplasms Tretinoin 11.6616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7810568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.7816530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.7816337965 17638652 15173087 16785472 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1511564622
MESH:D005124 Eye Abnormalities Tretinoin 8.159664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 11.6119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 11.6121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.6115345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.6610962813 14633661
MESH:D005355 Fibrosis Cyclosporine 13.1312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.1320067830
MESH:D005355 Fibrosis Tretinoin 13.1317994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4016452187
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 6.0212701121
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.948708960
MESH:D005909 Glioblastoma Genistein 6.6116598420
MESH:D005909 Glioblastoma Tretinoin 6.6117312396
MESH:D005910 Glioma Fluorouracil 6.0916145905
MESH:D005910 Glioma Thalidomide 6.0916327979
MESH:D006042 Goiter perchlorate 5.0518801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.1715102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.1716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8716084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.2320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.2311294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.239664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 4.4318590720
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6215340226 12621046 16120746
MESH:D015658 HIV Infections Nickel 3.6717263646
MESH:D006689 Hodgkin Disease sodium arsenite 2.9312676792
MESH:D019584 Hot Flashes Isoflavones 4.7017290160 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7618606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.0016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2916778211
MESH:D006973 Hypertension Cyclosporine 4.5810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5818670907 18850075
MESH:D006980 Hyperthyroidism Methimazole 5.3514678291
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416569931 16945680
MESH:D007037 Hypothyroidism Methimazole 11.0418031379
MESH:D007037 Hypothyroidism Propylthiouracil 11.048137927 18031379
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.0317937319
MESH:D007248 Infertility, Male sodium arsenite 6.0312646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 14.3518785209
MESH:D007249 Inflammation Nickel 14.3516166738
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.3512878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 14.3515177302 8273558 11698051 7812673 7562506
MESH:D007249 Inflammation Thalidomide 14.3516134734
MESH:D007410 Intestinal Diseases Tretinoin 3.4917994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.1015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1615604871
MESH:D007674 Kidney Diseases Cadmium 9.2516962696 16226777 16322080
MESH:D007674 Kidney Diseases Cyclosporine 9.2518776723 10903974 8314463
MESH:D007674 Kidney Diseases sodium arsenite 9.2520008137
MESH:D007680 Kidney Neoplasms Cyclosporine 6.6512371664
MESH:D007680 Kidney Neoplasms Fluorouracil 6.6516985049
MESH:D007898 Leishmaniasis, Visceral Thalidomide 4.1316514283
MESH:D007938 Leukemia Azacitidine 9.8019148494
MESH:D007938 Leukemia Genistein 9.8018980019 17468513
MESH:D007938 Leukemia Tretinoin 9.8017143497
MESH:D007951 Leukemia, Myeloid Azacitidine 8.9619077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.9616932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 6.0517596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 6.0518720364
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.0519850784 16294345 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.9319299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9717368321 19642359 16331271 16823087 19029980 16891316 12679006 19035177 16140955 17107899 15748426 17649720 16766008 17339181 17506722 16788101 17301526 17712046 16935935 17361223 19225113 19075265 17217047 17294898 9834237
MESH:D017880 Limb Deformities, Congenital Thalidomide 7.9010473037
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.909224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.5420032147 18407596 18522880 19638242 18665156
MESH:D008103 Liver Cirrhosis Thalidomide 6.5417174718 16943688
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.7217823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7212878042
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 4.7215465738
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.7218397230 16248980
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 6.4517184895
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4517034775
MESH:D008107 Liver Diseases Tetrachloroethylene 6.4517267091
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.232125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.2321137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.2319254457 20434301 18648771 2422723 19294768 20583210 19427195 19255062 12112319 20118626 18754104 19256749 19499222 19551842 18977376 19850985 12771043 20501860 21278145 19996281 19426721 19833225 18644402 9163691 19812893 15885732 20452335 21071580 19638242 21167192 15175105 10737359 20101389 20492335 19690152 19090486 20137499 19642983 21047994 20405173 16942905 2862719 19073162 18978307
MESH:D008113 Liver Neoplasms Ethylenethiourea 20.2311940454
MESH:D008113 Liver Neoplasms Fluorouracil 20.2316603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms sodium arsenite 20.2316712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.2316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 16.848603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.8419126423 18093689 18775883 18164116 19009564 18282651 16267830 17854601 18544905 2563599 18079962 19004024 19539802 19519916 3124819 17942915 18253720 18308698 9362446 17174075 16842330 21159647
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 16.84598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.8412151625
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 16.847955063
MESH:D008171 Lung Diseases sodium arsenite 2.9919095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 14.6814755239
MESH:D008175 Lung Neoplasms Azacitidine 14.6821224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.6818569708 20869020 20464547 6695378 18816296 18520028 20135361 20064080 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.6820970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Fluorouracil 14.6815246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 14.6811893704 16337739 21163286 20970405 16271038 7750092 17909032 1399818 6695378 15390079 10545420 9230183 20512841
MESH:D008175 Lung Neoplasms sodium arsenite 14.6817306315 19931552 16712894 15276417 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.6819555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 14.6811807781
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5115086387
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 9.1911921183
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.1912929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 9.198985016
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma sodium arsenite 4.9519082730 16487513
MESH:D008545 Melanoma Thalidomide 4.9512829675 17089043 16098027
MESH:D008545 Melanoma Tretinoin 4.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.1516940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5016801185
MESH:D009006 Monosomy Azacitidine 5.8019299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.8316381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.8316757204 18986760
MESH:D009101 Multiple Myeloma Azacitidine 7.3518443271 19549372
MESH:D009101 Multiple Myeloma Thalidomide 7.3515939924 15867202 16445831 19112201 15920492 17168659 15744524 19112817 15741222 19372569
MESH:D009190 Myelodysplastic Syndromes Azacitidine 11.6517611569 19805378 17596541 18720364
MESH:D009190 Myelodysplastic Syndromes Thalidomide 11.6518720364
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.6517596541
MESH:D009203 Myocardial Infarction Genistein 2.7417141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.4517141266
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.469029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 14.2711141357
MESH:D009369 Neoplasms Fluorouracil 14.2718600527 16928823 18239605
MESH:D009369 Neoplasms sodium arsenite 14.2711559025
MESH:D009369 Neoplasms Tetrachloroethylene 14.2711911487
MESH:D009369 Neoplasms Tretinoin 14.2716946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3920056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0519348381 18481113
MESH:D009421 Nervous System Malformations Genistein 21.3116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.3114600291
MESH:D009421 Nervous System Malformations Thalidomide 21.3116859833
MESH:D009421 Nervous System Malformations Tretinoin 21.319125849
MESH:D009436 Neural Tube Defects sodium arsenite 6.7112854658
MESH:D009436 Neural Tube Defects Tretinoin 6.719142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8320387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2516436463
MESH:D010024 Osteoporosis Genistein 7.0219401787
MESH:D010024 Osteoporosis Isoflavones 7.0216562857
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8316169203
MESH:D010051 Ovarian Neoplasms CD 437 14.0417474084
MESH:D010051 Ovarian Neoplasms Genistein 14.0419005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.0417306315 15276417
MESH:D010051 Ovarian Neoplasms Thalidomide 14.0416288038
MESH:D010051 Ovarian Neoplasms Tretinoin 14.0416936753
MESH:D010146 Pain Tretinoin 2.6916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.5116540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.5119003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 11.5115976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.5115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.0218404319 12065085 18922899 8330346
MESH:D010291 Paresis Thalidomide 6.029200351
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 12.8420133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 12.8412520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.1015687053
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.1712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.172563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 4.0717031469
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9111118676 11399792 11222880 11896295
MESH:D011471 Prostatic Neoplasms Azacitidine 2.3918324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3917292933
MESH:D011471 Prostatic Neoplasms Cadmium 2.3917075824
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.3918626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 2.3915378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Isoflavones 2.3917374662 17571952 17219775 16365062
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3916039940
MESH:D011471 Prostatic Neoplasms Thalidomide 2.3916729912
MESH:D011507 Proteinuria Tretinoin 3.3516636307
MESH:D011536 Prurigo Thalidomide 6.0212755975
MESH:D011537 Pruritus Ethinyl Estradiol 3.0316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1316882103
MESH:D011625 Pterygium Tretinoin 4.5116723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7818286688 15538739 18722050 16160472
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8416116481 16283617
MESH:D019873 Schnitzler Syndrome Thalidomide 5.6616096327
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 20.7510029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 20.7519524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 20.758532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 20.7516192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 20.758330346 8985016 18404319 12065085 11807781
MESH:D012878 Skin Neoplasms Tretinoin 20.7516467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6616709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5812854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.4620155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4618456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.4619015929 16424979 16951190 18396642 19084572 17522103 17498489 18567086 17172411 15786421
MESH:D013274 Stomach Neoplasms Tretinoin 4.4617261132
MESH:D013276 Stomach Ulcer Thalidomide 3.9315138204
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.5120133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.497505956
MESH:D013964 Thyroid Neoplasms Ethylenethiourea 15.4911940454
MESH:D013964 Thyroid Neoplasms Propylthiouracil 15.4915710170
MESH:D013964 Thyroid Neoplasms Tretinoin 15.4916026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 9.0316280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.0316051514
MESH:D014376 Tuberculosis Tretinoin 3.0616040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.7917053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 7.7916720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.7916712894 11723127 17306315 16452187
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.4616803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.4611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.4616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3316752155
MESH:D014605 Uveitis Cyclosporine 3.701336536
MESH:D014652 Vascular Diseases sodium arsenite 11.1917056641
MESH:D014652 Vascular Diseases Thalidomide 11.1915741222
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2914671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.7916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D009396 Wilms Tumor Tretinoin 3.7316287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1617120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03431 - Adenosine-5'-Diphosphate
DB04395 - Phosphoaminophosphonic Acid-Adenylate Ester
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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